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Öğe Comparison of major lymphocyte subpopulations and recent thymic emigrants in patients with ataxia telangiectasia and age-matched healthy groups(Elsevier Doyma Sl, 2015) Celiksoy, M. H.; Topal, E.; Yildiran, A.Background: Ataxia telangiectasia (A-T) is a genetic disorder caused by the homozygous mutation of the A-T mutated gene. It is frequently associated with variable degrees of cellular and humoral immunodeficiency. However, the immune defects in A-T patients are not well characterized. To the best of our knowledge, no studies have focused on the major lymphocyte subpopulations and recent thymic emigrants of A-T patients in comparison with age-matched healthy controls. Methods: Following the European Society for Immunodeficiencies criteria, 17 patients diagnosed with A-The, and 12 age-matched healthy children were assigned to the study. Both patients and healthy controls were grouped as 1-5, 6-10, 11-15, and 15+ years. By using a flow cytometer, major lymphocyte subpopulations and CD4+CD45RA+CD31+ recent thymic emigrants were determined as percentage and absolute cell numbers and compared. Results: No significant differences in all lymphocyte subpopulations were observed between the age groups of A-T patients. Compared to the healthy controls, there was a decrease in T cells, effector memory T4 cells, B cells, naive B cells, naive 14 cells, switched B cells, and recent thymic emigrants and an increase in active 18 cells and non-switched B cells in the percentage and absolute number of some cell populations in the A-T group. Conclusions: This study showed that effector functions in some cell lymphocyte populations were decreased in A-T patients. (C) 2014 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Psychiatric disorders and symptoms severity in pre-school children with cow's milk allergy(Elsevier Doyma Sl, 2016) Topal, E.; Catal, F.; Soylu, N.; Ozcan, O. O.; Celiksoy, M. H.; Babayigit, A.; Erge, D.Background: Psychiatric disorders are seen frequently in atopic diseases. The present study aims to evaluate the frequency of psychiatric disorders and the severity of psychiatric symptoms in pre-school children with cow's milk allergy. Methods: The parents of the pre-school children with cow's milk allergy were interviewed in person and asked to fill out the Early Childhood Inventory-4 form. Results: The cow's milk allergy group included 40 children (27 male, 13 female) with mean age, 44.5 +/- 14.7 months, and the control group included 41 children (25 male, 16 female) with mean age, 47.6 +/- 15.2 months. It was established that 65% of the group with cow's milk allergy received at least one psychiatric diagnosis, while 36.6% of the control group received at least one psychiatric diagnosis, with a statistically significant difference (p = 0.02). Within the psychiatric disorders, attention deficit hyperactivity disorders (odds ratio: 4.9, 95% CI: 1.472-16.856, p = 0.006), oppositional defiant disorder (odds ratio: 5.6, 95% CI: 1.139-28.128, p = 0.026), and attachment disorder (odds ratio: 4.8, 95% CI: 1.747-13.506, p = 0.004) were found significantly higher compared with the healthy control group. When the groups were compared in terms of psychiatric symptom severity scores, calculated by using the Early Childhood Inventory-4 form, attention deficit hyperactivity disorders severity (p= 0.006) and oppositional defiant disorder severity (p = 0.037) were found to be higher in the cow's milk allergy group. Conclusion: Psychiatric disorders are frequent and severe in pre-school children with cow's milk allergy. (C) 2016 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Psychiatric disorders and symptoms severity in preschool children with atopic eczema(Elsevier Espana Slu, 2016) Catal, F.; Topal, E.; Soylu, N.; Ozcan, O. Ozel; Celiksoy, M. H.; Babayigit, A.; Karakoc, H. T. E.Background: To compare with a control group the frequency of psychiatric disorders and severity of psychiatric symptoms in preschool children with atopic eczema. Methods: The study included children between the ages of 3-5 who were diagnosed to have atopic eczema. The parents of the children with atopic eczema were interviewed in person and were asked to fill in The Early Childhood Inventory-4 form. This form assesses the psychiatric disorders and symptoms severity in children between the ages of 3-5. Results: The atopic eczema group included 80 patients (38 male, 42 female) with a mean age of 48.4 +/- 15.7 months and the control group included 74 patients (41 male, 33 female) with a mean age of 49.9 +/- 15.19 months. It was established that 68.8% of the group with atopic eczema received at least one psychiatric diagnosis. Between the psychiatric disorders, ADHD (Odds ratio: 2.57, 95% CI: 1.049-6.298, p=0.035), enuresis and encopresis (Odds ratio: 2.39, 95% CI: 1.121-5.097, p=0.022) and attachment disorder (Odds ratio: 2.03, 95% CI: 1.046-3.953, p=0.035) were found to be significantly higher when compared with the healthy control group. When the groups were compared in terms of psychiatric symptom severity scores calculated by using ECI-4, ADHD severity (p=0.043), conduct disorder severity (p=0.001), anxiety disorders severity (p < 0.001), eating disorders severity (p = 0.011) and tic disorder severity (p = 0.01) were found to be higher in the atopic eczema group. Conclusion: Psychiatric illnesses are frequent in preschool children with atopic eczema. (C) 2015 SEICAP. Published by Elsevier Esparta, S.L.U. All rights reserved.Öğe Psychiatric disorders and symptoms severity in preschool children with cow's milk allergy(Wiley-Blackwell, 2016) Topal, E.; Catal, F.; Soylu, N.; Ozcan, O. O.; Celiksoy, M. H.; Babayigit, A.; Erge, D.[Abstract Not Available]Öğe The value of the clinical history for the diagnosis of immediate NSAIDs hypersensitivity and safe alternative drugs in children(Wiley-Blackwell, 2016) Topal, E.; Celiksoy, M. H.; Catal, F.; Sayan, Y. G.; Sancak, R.[Abstract Not Available]
