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Öğe Effectiveness of human albumin solution in the treatment of patients with cirrhosis(2022) Cengiz, Ayse Nuransoy; Cagin, Yasir Furkan; Seckin, Yuksel; Karıncaoğlu, MelihAbstract Aim: Human serum albumin is synthesized in the liver and is the main plasma protein responsible for plasma oncotic pressure. Studies on the use of Human albumin solution (HAS) in patients with cirrhosis, for prevention of cirrhosis complications or for treatment are ongoing. The beneficial role of albumin beyond volume expansion is an evolving topic, and further research is needed to understand its role in modulating biological functions and disease processes, particularly in liver disease and sepsis, but also in other diseases that involve albumin dysfunction. Materials and Methods: We investigated the effectiveness of HAS through the patients with cirrhosis who received 3 consecutive days (2x1 per day) 190-210 g / L protein were retrospectively analyzed. Results: Albumin infusion was found to be beneficial for serum albumin levels in the patient with high Child-Pugh scores. Conclusion: The complications of cirrhosis can be reduced, particularly in patients awaiting transplantation, by support with HAS treatment.Öğe Evaluation of Development of Nonalcoholic Fatty Pancreas Disease After Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis in Liver Transplant Patients: Computerized Tomography Versus Ultrasound(Aves, 2023) Cengiz, Ayse Nuransoy; Bilgic, Yilmaz; Karatoprak, Sinan; Gokce, Ayse; Evren, Bahri; Akbulut, Sami; Yilmaz, SezaiBackground/Aims: Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is the most common serious adverse event in liver transplant patients The average incidence has been reported as 1.3%-15.1% in prospective series. In our study, we have prospectively evaluated the prevalence of nonalcoholic fatty pancreatic disease (NAFPD) after PEP via computerized tomography (CT) and determined the ratio of fatty pancreas by ultrasound imaging in liver transplant patients. Materials and Methods: We have retrospectively analyzed 2922 patient files, and 146 patients were indicated for ERCP. PEP was observed in 32 patients. After presenting the significant association between the NAFPD and PEP, we prospectively reached 32 patients included in the study. Ten out of those patients have been performed ultrasound with regard to NAFPD. Results: PEP was defined in 32 patients in whom CT was performed to investigate NAFPD. When the patients were contacted, it was observed that 12% were deceased, 71% were alive, but 15% of them were untraceable. Ultrasound has been performed on 10 of 32 patients to determine NAFPD. There was a significant reduction in post-PEP pancreas/spleen rate compared to pre-PEP pancreas/ spleen rate (P =.001). Both the pre-PEP and post-PEP pancreas-spleen difference dropped significantly (P =.002). Conclusion: Ultrasound imaging could be utilized as a scanning test and an alternative to evaluate and diagnose NAFPD, particularly in risky patients.Öğe Investigation of hepatitis B virus prevalence and reactivation frequency in malignancy patients administering chemotherapy(2021) Cengiz, Muhammet; Seckin, Yuksel; Cagin, Yasir Furkan; Cengiz, Ayse NuransoyAim: This study aimed to investigate the frequency at which physicians test hepatitis B virus (HBV) serology before treatment and the rate of hepatitis B virus reactivation (HBVr) after treatment in patients undergoing chemotherapy (CT) due to a solid organ malignancy (SOM) or hematological malignancy (HM). Materials and Methods: Baseline clinical feature, HBV serology, and liver function test data for 1275 patients ? 18 years of age who underwent CT for the first time due to various SOMs and HMs from 2015-2017 were obtained from the database and retrospectively analyzed. HBV serology was studied in 296 (201 HM, 95 SOM) of the 1275 patients retrieved from the database. Results: The prevalence of HBV was 9.5% (121 patients). Only 49 (40.4%) HBV-positive patients had HBV DNA. Of those, 72 (59.5%) underwent prophylactic antiviral therapy. HBVr was detected in only 3 patients (1.5%), and all of those patients had HMs and were recommended oral antiviral therapy but did not. Conclusion: In patients with SOMs, the screening rates of HBV serology, as well as prophylaxis and follow-up HMs were extremely low. Therefore, these patients should be screened for HBV serology and prophylactic treatment should be given when necessary for HBVr.Öğe Long term functional graft survival results of the 3rd stage single centre living and cadaveric donor transplants(2023) Cengiz, Ayse Nuransoy; Şahin, İdris; Sarı, Merve; Rüstem, Telman; Gökçe, AyseAim: Kidney transplantation is the most optimal end stage renal disease (ESRD) treatment. It is more advantageous treatment regard to both its effect on the patient’s life quality or mortality. The number of patients who underwent or followed after renal transplant is constantly increasing while their survival becomes a topic more frequently. Different centers therefore report different survival rates in the post-transplantation process. In this study, the transplantation progress and the functional graft survival rates of the patients who have received renal transplants and are followed in our center and the factors which influence the survival rates are explored. Materials and Methods: The patients over 18 years old who applied to Inonu University Turgut Ozal Medical Center Nephrology Department Policlinics who received transplants retrospectively analyzed. Results: While the median for the functional graft period of the patients were 60 months, the longest was found to be 240 months. The grafts of our 77% patients are functional, while 3.7% are exitus with functional graft due to various reasons. 5.3% of the patients received HD again, 3% started PD and 1.3% underwent retransplantation. Conclusion: While the number of transplants are increasing day by day in Turkey, studies on the long term functional graft survival results and the patients’ pre- and posttransplant characteristics are limited and there is not much literature data related to Turkey. We aimed to contribute to the literature with our data. Also, the duration of ESRD increases, the lower is the functional graft time significantly. The preferred ESRD treatment should, therefore, be renal transplantation. Renal transplants could be preferred in suitable patients or donors of advanced age, and transplant age spectrum could be extended.
