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Öğe A case with a delayed diagnosis of extrafacial rosacea(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2019) Cenk H.; Saraç G.; Kapicioğlu Y.Rosacea is a chronic, inflammatory skin disorder involving the central part of the face. There are four main subtypes of the disease which are most commonly seen; but also, when the disease involves other parts of the body except the face, it's called extrafacial rosacea (ER). ER is rarely reported in the literature and it may involve the scalp, chest and the back Herein, a man with ex-trafacially located rosacea who couldn't have been diagnosed for long years will be presented because of the rarity of the disease. Copyright © 2019 by Türkiye KlinikleriÖğe Does Systemic Isotretinoin Treatment Constitute a Predisposition to Allergic Sensitization?(NLM (Medline), 2021) Cenk H.; Kapicioglu Y.; Yologlu S.13-cis-retinoic acid (13-cRA) is a safe treatment for severe acne, as it has immunomodulatory effects such as enhancing the antigen-presenting activity of epidermal Langerhans cells (LCs) and T-cell activity. The aim of this study was to prospectively show the alteration of sensitization and irritation reactions in acne patients undergoing 13-cRA therapy. This cross-sectional descriptive study consisted of 65 severe to refractory acne patients. The standard thin-layer rapid-use epicutaneous test (T.R.U.E. test) was used to screen sensitization and irritation reactions before and after 3-month 13-cRA treatment. Patch test results after 13-cRA therapy revealed an increase in newly formed sensitization and irritation reactions. Sensitization rate was significantly higher (43.1%) in the second patch test, when compared with the first patch test results (27.7%; P = 0.002). No statistical difference was found in irritation rates. In this study, the sensitization rate was higher after treatment, which could be attributed to the greater antigen penetration due to the disrupted barrier and/or the upregulation of antigen-presenting activity in LC. This would cause a more prominent immune reaction to antigens. Based on these findings, we suggest that 13-cRA may have a sensitization effect, and physicians should be aware of this complication due to 13-cRA treatment. (SKINmed. 2021;19:-0).Öğe Intravascular lymphoma presenting with paraneoplastic syndrome(Dermatology Online Journal, 2020) Cenk H.; Sarac G.; Karadağ N.; Berktas H.B.; Sahin I.; Sener S.; Kisaciık D.Intravascular lymphomatosis (IVL) is a rare type of B-cell non-Hodgkin lymphoma (BCNHL), which can mimic many other diseases. Fever, neurological symptoms, and skin findings are the most frequent clinical findings. Intravascular lymphomatosis may be associated with genetic factors and infection with human immunodeficiency virus (HIV), human herpesvirus 8 (HHV-8), human T-lymphotropic virus 1 (HTLV1), Epstein-Barr virus (EBV), and hepatitis B virus (HBV). A 50-year-old man was hospitalized with recalcitrant hyponatremia of unknown cause. He had also telangiectatic, indurated, slightly erythematous plaques on his trunk for the last 10 days. His past medical history was unremarkable, although he was a carrier of hepatitis B. Multiple skin biopsies were performed and were considered to be diagnostic of IVL. The hyponatremia was unresponsive to water restriction and hypertonic solution support but it resolved with B cell directed chemotherapy. A final diagnosis was made as syndrome of inappropriate antidiuretic hormone (SIADH) in the setting of IVL. This case had a relatively early diagnosis with just 10-days of skin lesions. Intravascular lymphomatosis is a very rare disease and is usually difficult to diagnose. An even more uncommon presentation is IVL complicated by a paraneoplastic syndrome. There are prior reported cases of SIADH in the setting of IVL. However, this case underscores the importance of evaluating patients with SIADH for potential IVL. © 2020 Dermatology Online Journal. All rights reserved.Öğe Knuckle pads as a psychocutaneous manifestation in a stressed-out child(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2021) Cenk H.; Saraç G.; Özcan K.N.Knuckle pads (KP) are benign, firm papules, nodules, or plaques on the dorsal joints of the hands or toes. It's mostly idiopathic, also, children who bite and suck their fingers may have KP. An 11-year-old child was brought to our polyclinic with the complaint of thickness on his hand joints. The child was healthy otherwise, he didn't have joint pain and family history. He was questioned in terms of being under any kind of stress. He said that his schoolmates were always making fun of him. When he was asked if he was using his hands in those moments to relax, he said “yes” and showed the movement. His father confirmed that the kid was experiencing an adaptation problem in the school, then, he is referred to the department of child psychiatry. KP is associated with lots of factors but especially in children, it may be a psychocutaneous manifestation. Also, it may cause a social embarrassment triggering the vicious cycle of stress-related pathogenesis. © 2021 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Öğe Recurrent angiolymphoid hyperplasia with eosinophilia during several pregnancies(Dermatology Online Journal, 2020) Cenk H.; Kapicioglu Y.; Sarac G.; Sener S.; Sahin N.Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign vascular tumor. Although its etiology is not clearly known, infection, hormonal factors, and trauma are the suspected reasons. There are few cases considered to be related to pregnancy described in the literature. Granulomas are rarely seen in the histopathology and only four patients with granulomas have been described. Herein, we will present a 28-year-old woman who has been pregnant three times; in every pregnancy, she developed pink nodular lesions on the back of her ear. In the first two pregnancies, the lesions had appeared during the pregnancy and regressed completely in the postpartum period. In her third pregnancy, the condition emerged again and lasted 1.5 years after birth of her child. Histopathology exhibited ALHE with granulomas. Although the relationship between ALHE and pregnancy is already known, there are few cutaneous ALHE cases associated with pregnancy reported in the literature. This association is further supported by this case having recurrent ALHE during each pregnancy period. Also, the presence of naked granuloma in histopathology, unlike most of the cases, contributes to the current histopathological data. © 2020 Dermatology Online Journal. All rights reserved.
