Yazar "Cetin, Aymelek" seçeneğine göre listele
Listeleniyor 1 - 8 / 8
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Effects of ciprofloxacin and quercetin on fetal brain development: a biochemical and histopathological study(Taylor & Francis Ltd, 2019) Dogan, Zumrut; Cetin, Aymelek; Elibol, Ebru; Vardi, Nigar; Turkoz, YusufPurpose: Teratogens cause birth defects and malformations while human development is being completed. In pregnancy, urinary tract infection (UTI) is a common health problem caused by bacteria. The fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin, and gemifloxacin can treat various types of bacterial infections successfully. The aim of this study is to determine whether the use of ciprofloxacin during pregnancy causes oxidative stress on brain tissues of the fetus, and whether quercetin contributes to prevent this damage if stress has already occurred.Materials and methods: In our study, 22 young female Wistar albino rats weighing 250g were used. Rats were mated overnight in separate plastic cages. Female rats were regarded as pregnant when a vaginal plug was observed, and these were divided into four groups of control, ciprofloxacin, quercetin, and cipro+quercetin. Two daily i.p. 20mg/kg doses of ciprofloxacin were administered to ciprofloxacin group between 7 and 17 d of pregnancy. Throughout the study, daily (20 d) 20mg/kg quercetin was dissolved in corn oil and administered to the quercetin group by oral gavage. Rats were fed ad libitum throughout the study. Fetuses were taken by C-section on the 20th day of pregnancy. Thereafter, the brain tissues were subjected to histological assessments and biochemical analyzes.Results: The experimental groups were compared with the control group; ciprofloxacin affected fetal development, especially caused damage to neurons in brain tissue and cause hemorrhagic defects. And also, it was determined that many parameters were affected such as antioxidant parameters, enzyme levels and levels of malondialdehyde (MDA) (a marker of lipid peroxidation). Quercetin is a member of flavonoid with strong antioxidant properties, and our results indicate that the use of ciprofloxacin in pregnancy can result damage to fetal brain tissue.Conclusions: Unlike these results when some parameters are evaluated it is understood that this harmful effects suppressed by quercetin.Öğe The evaluation of the effect of vaginal delivery and aging on anal sphincter anatomy and function(Elsevier Masson, Corporation Office, 2018) Cay, Mahmut; Cetin, Aymelek; Ates, Mustafa; Koleli, Isil; Senol, Deniz; Kose, Evren; Ozgor, DincerObjective. - This study was conducted to evaluate the effect of vaginal delivery and aging on anal sphincter anatomy and function. Method. - Asymptomatic thirty women were included in this prospective study. Group 1 included 10 women (age range: 18-50) who had never been pregnant. Group 2 included 10 women (age range: 18-50) who had vaginal delivery. Group 3 included 10 women over 50 who had vaginal delivery. Results. - There was no statistically significant difference between the three groups in terms of resting and squeeze pressures. It was found that sphincter thickness showed statistically significant difference between the group 1 and group 3, and also group 2 and group 3. There was not statistically significant difference between the group 1 and group 2 in terms of sphincter thickness. There was a positive correlation between the age and sphincter thickness in all groups. In terms of sphincter thickness and pressure findings there was a positive correlation between the squeeze pressure and external anal sphincter thickness only in group 3. Conclusion. - The vaginal delivery did not have a negative influence on the structure and function of the anal sphincter in asymptomatic women. However, it was found that anal sphincter thickness changed strongly in a positive manner with aging. (C) 2018 Elsevier Masson SAS. All rights reserved.Öğe The evaluation of the effect of vaginal delivery and aging on anal sphincter anatomy and function (vol 47, pg 309, 2018)(Elsevier Masson, Corp Off, 2020) Cay, Mahmut; Cetin, Aymelek; Ates, Mustafa; Koleli, Isil; Senol, Deniz; Kose, Evren; Ozgor, Dincer[Abstract Not Available]Öğe The evaluation of the effect of vaginal delivery and aging on anal sphincteranatomy and function(Elsevıer masson, corporatıon offıce, 65 camılle desmoulıns cs50083 ıssy-les-moulıneaux, 92442 parıs, france, 2018) Cay, Mahmut; Cetin, Aymelek; Ates, Mustafa; Koleli, Isil; Senol, Deniz; Kose, Evren; Ozgor, Dincer; Simsek, Arife; Ozbag, DavutObjective. - This study was conducted to evaluate the effect of vaginal delivery and aging on anal sphincter anatomy and function. Method. - Asymptomatic thirty women were included in this prospective study. Group 1 included 10 women (age range: 18-50) who had never been pregnant. Group 2 included 10 women (age range: 18-50) who had vaginal delivery. Group 3 included 10 women over 50 who had vaginal delivery. Results. - There was no statistically significant difference between the three groups in terms of resting and squeeze pressures. It was found that sphincter thickness showed statistically significant difference between the group 1 and group 3, and also group 2 and group 3. There was not statistically significant difference between the group 1 and group 2 in terms of sphincter thickness. There was a positive correlation between the age and sphincter thickness in all groups. In terms of sphincter thickness and pressure findings there was a positive correlation between the squeeze pressure and external anal sphincter thickness only in group 3. Conclusion. - The vaginal delivery did not have a negative influence on the structure and function of the anal sphincter in asymptomatic women. However, it was found that anal sphincter thickness changed strongly in a positive manner with aging. (C) 2018 Elsevier Masson SAS. All rights reserved.Öğe Evaluation of Willis Polygon Morphometry with Cranial Tomographic Angiography(Turkish Neurosurgical Soc, 2023) Ciftci, Rukiye; Cetin, Aymelek; Ulubaba, Hilal Er; Senol, Deniz; Cinarli, Fahri Safa; Ozbag, DavutAIM: To examine the morphometric properties of the vessels forming the Willis polygon (WP) in patients with type 2 diabetes mellitus (T2DM) and hypertension (HT) and compare them with healthy individuals.MATERIAL and METHODS: Cranial Tomography Angiography (CTA) of 168 individuals were analyzed retrospectively. The individuals included in the study were divided into four groups according to the diagnosis. Group 1 included 40 individuals who were diagnosed with HT, Group 2 included 43 individuals who were diagnosed with DM, Group 3 included 42 individuals who were diagnosed with DM and HT, and Group 4 was the control group and included 43 individuals. The diameter and length measurements of the vesselsRESULTS: According to the results of the Kruskal Wallis H test, in female patients statistically significant differences were detected in the diameter measurements of the right and left A1 segment of the ACA, the diameter measurement of the left A2 segment, the diameter measurements of the right and left P1 and P2 segments of the ACP, the diameter measurements of the right and left AComP. (p<0.05), in male patients statistically significant differences were found in the diameter of the right A1 segment of the ACA, the diameter and segment length measurements of the right and left P1 segments of the ACP, of the right and left P2 diameter measurements, and segment length measurements of the left AComP (p<0.05).CONCLUSION: We also found that the vessel diameters were similar in the HT, DM and HT+DM groups, and smaller than the control group. In addition, we think that knowing WP morphometric measurements will both guide the radio-anatomical evaluations to be made and increase the level of microanatomical knowledge in surgical treatment.Öğe Morphometric Evaluation of the Craniovertebral Junction Using Computed Tomography: A Sex-Based Analysis of 500 Adults(Wiley, 2026) Fidan, Nuri; Cetin, Aymelek; Tosun, AlptekinBackground and Objective: The anatomy of the craniovertebral junction (CVJ) varies considerably across populations, yet comprehensive Turkish-specific morphometric data remain limited. We aim to establish normative CVJ measurements in Turkish males and females using computed tomography (CT). Study Design: Retrospective morphological study. Materials and Methods: A retrospective analysis of CT images from 500 patients (250 females and 250 males, aged 25-40 years) was conducted between January and December 2022. CVJ measurements were obtained, and sex-related differences were assessed. Results: The mean atlantodental interval was 1.45 +/- 0.01 mm, posterior atlantodental interval 19.35 +/- 0.09 mm, McGregor line 79.78 +/- 0.21 mm, Chamberlain line 76.95 +/- 1.21 mm, McRae line 36.27 +/- 0.12 mm, Wachenheim clivus-canal angle 154.65 +/- 0.45 degrees, sphenoid angle 121.15 +/- 0.39 degrees (no sex difference, p = 0.083), Welcher basal angle 130.02 +/- 0.28 degrees (higher in females, p < 0.001), basion-axial interval 7.13 +/- 0.07 mm (higher in males, p = 0.011), basion-dental interval 5.32 +/- 0.06 mm, and craniocervical tilt angle 123.94 +/- 0.44 degrees (higher in males, p < 0.001). Conclusion: This study provides a comprehensive CT-based analysis of CVJ measurements in Turkish adults, establishes normative morphometric values, and shows that most parameters exhibit sex-based differences. These population- and sex-specific reference data may be crucial for improving the accuracy of clinical assessments and surgical planning.Öğe Prevalence of flat foot among elementary school students, in rural and urban areas and at suburbs in Anatolia(Springer, 2011) Cetin, Aymelek; Sevil, Sedat; Karaoglu, Leyla; Yucekaya, BircanAbout 326 elementary school boys and 299 elementary school girls of an age ranging from 6 to 13 are included in this flat foot prevalence study. Results of the study are categorized in three groups, namely city centers, rural areas and suburbs. For the assessment of flat foot, footprint test is used. Prevalence of flat foot was 35.5% among girls and 28.5% among boys. Flat foot was associated with child age, residency and body mass index (BMI). Flat foot prevalence was highest among 6-year-old children, and lowest among 11-year and older children (P < 0.05). Flat foot prevalence was lower among children living in rural areas and children with low BMI value (P = 0.001). More overweight and at risk of overweight children had flat foot compared to normal and underweight children (P < 0.05). Familial predisposition was also noted for flat foot; 16.1% of children with flat foot had a familial history of flat foot, while this rate was only 5.6% in families of healthy subjects (P = 0.001).Öğe Sacrectomy Margins for Rectal Cancer Invading Sacrum: An Anatomic Study(Wiley-Blackwell, 2011) Aydin, Cemalettin; Kayaalp, Cuneyt; Cetin, Aymelek[Abstract Not Available]
