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    Impairment of Peripheral Nerve Healing After Nerve Repair in Rats Chronically Exposed To Alcohol
    (Elsevier Science Inc, 2009) Ertem, Kadir; Ceylan, Fethi; Zorludemir, Suzan; Karakoc, Yunus; Yologlu, Saim
    Background and Aims. The aim of this study was to determine the effect of chronic alcoholism on the healing of repaired peripheral nerve and muscle. Methods. Group 1 rats (n = 9) were fed with an alcohol-free modified liquid diet (MLD) throughout the experiment and received no nerve transection or repair. Group 2 rats (n = 9) were fed the same isocaloric MLD and underwent nerve transection and repair. Group 3 (n 7) consisted of alcoholic rats without nerve transection and repair and Group 4 (it 8) consisted of alcoholic rats with nerve transection and repair. To assess the effects of chronic alcoholism on nerve healing, surgical procedures were applied to rats in Groups 2 and 4. After 2 months, posterior tibial nerve and gastrocnemius muscle samples were taken for histological analysis. Results. Group 2 rats displayed a group of atrophic fibers, whereas Group 3 rats showed myophagocytosis and endomysial mononuclear infiltration and type 2 fiber atrophy. Group 4 rats displayed a large section of atrophic fibres. Axonal loss, prominent regenerative clusters and endoneural fibrosis Occurred in Group 2 rats. Axonal and myelin degeneration, myelin remnants and thinly myelinated axons were exhibited in Group 3 rats. whereas severe axonal loss, myelin degeneration, regenerative clusters and endoneural fibrosis were discovered in Group 4. There was a significant difference in the number of myelinated axons among the various groups of rats. Conclusions. Our findings show that chronic alcoholism has a negative influence oil peripheral nerve regeneration associated with a significant decrease in axon number and increased axonal degeneration. (C) 2009 IMSS. Published by Elsevier Inc.