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    Prognostic importance of progesterone receptor expression in meningioma
    (2020) Ceylan, Onur; Ozmen, Sevilay
    Aim: : In this study, our objective was to demonstrate the relationship of progesterone receptor (PR) expression with histological grade and other prognostic factors in patients with meningiomas. Material and Methods: Brain biopsy materials, which were examined and diagnosed with meningioma between January 2011 and January 2015, were screened in a retrospective study design. Ninety-six of the cases, who were diagnosed with meningioma with a grade of I, II, and III according to WHO and had undergone immunohistochemically PR expression, were included in the study.Results: JThere was a weak correlation between WHO grade and PR expression rate and intensity in our study. PR expression rate and intensity showed increment as the grade progressed. On the other hand, there was no correlation of PR expression rate and intensity with other prognostic parameters such as Ki67 proliferation index and mitotic index. Conclusion: Although we have detected a weak correlation between PR expression rate and intensity with WHO grade, we think that PR expression rate and intensity do not have prognostic role in the meningiomas due to the absence of a similar relationship between other important parameters in prognosis. In most of the studies in the literature, it is reported that PR expression rate and intensity decreases with increasing WHO grade. However, the number of studies with the opposite results is high. In the presence of conflicting data in the literature and considering that almost all of these studies were performed according to the WHO classification before 2016 (before the new WHO classification), we concluded that further multi-centre studies utilizing new classification system and have more homogeneous distribution of the grades are required to investigate the relationship between PR and histopathologic grade and other prognostic parameters.
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    Relationship between prostate cancer and atypical small acinar proliferation
    (2019) Ceylan, Onur; Demirtas, Rabia; Kurt, Ali; Can, Yusuf; Kabalar, Mehmet Esref; Bilici, Ahmet Erkan; Balta, Hilal
    Aim: To investigate the prostatic adenocarcinoma (PA) detection rate in follow up biopsies with an initial diagnosis of atypical small acinar proliferation (ASAP). Materials and Methods: In this study, the cases of ASAP diagnosis in prostate needle biopsy materials between January 2010 and December 2016 were retrospectively analyzed and the correlation between the results and the follow-up diagnoses of ASAP-diagnosed cases was investigated. Results: 62 cases with ASAP were included in the study and 21 (34%) of them were detected as PA after the follow-up diagnoses. Also ASAP and PA were detected at different localizations in 38% of the cases. Conclusion: We are on the opinion that it is important to increase the number of samples taken from other localizations as well as ASAP diagnosed quadrants when taking follow-up biopsies.
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    Robot assisted partial nephrectomy: Single center our experiences
    (2019) Karabulut, Ibrahim; Yilmaz, Ali Haydar; Yilmazel, Fatih Kursat; Ceylan, Onur
    Aim: In this study, we aimed to present the functional and oncologic results of robotic assisted partial nephrectomy (RAPN) in clinical stage T1 tumors.Material and Methods: Fifteen patients who had undergone RAPN for T1a-b kidney tumor between July 2017 and January 2019 were included in the study. The demographic data, mean operation time, estimated blood loss, duration of warm ischemia, length of hospital stay and oncologic results were evaluated retrospectively.Results: Ten male and five female patients with a mean age of 55.4±7.6 (48-71) years were included in the study. A 4-port trans peritoneal approach was applied to all the patients. Nine right and six left renal masses with a mean tm diameter of 2.8±0.4 (2.4-3.6) cm were operated. The mean operation time was 217 (185-250) minutes, the mean blood loss was 225.6 (180-265) cc. Bleeding requiring transfusion was seen in one patient and a spontaneously resolved ileus was seen in another patient. Urethral stents were placed into two patients because the collector system was opened. 8 (53%) of renal masses were reported as renal cell carcinoma. Surgical margin positivity was identified in 2 (13%) of the patients. No local recurrence or distant metastasis was observed in any of the patients. None of the patients experienced incisional hernia and late complications. Conclusion: Robot-assisted partial nephrectomy is presently the gold standard treatment for patients with clinical stage T1 renal tumor. RAPN is an effective, safe and minimally invasive treatment modality in patients eligible for partial nephrectomy.