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    Effects of misoprostol on bone loss in ovariectomized rats
    (Elsevier Science Inc, 1999) Sonmez, AS; Birincioglu, M; Özer, MK; Kutlu, R; Chuong, CJ
    This study was performed to investigate whether misoprostol (prostaglandin Fl analogue) (Cytotec, Searle, England) is effective for restoration of bone loss. Four-month-old parous female Sprague-Dawley rats (n = 30) were subjected either to bilateral ovariectomy (OVX, 24 fats) or to sham surgery (sham, 6 rats), The OVX rats were divided into four groups 60 days after the surgery. Six of them were killed, and dual-energy X-ray absorption (Norland xr-36, Norland Corporation, Fort Atkinson, WI, USA) measurements were performed, called pretreatment OVX group. The remaining groups teach had 6 rats) treated orally with 0 (control), 100, 200 mu g/kg/day misoprostol for 60 days. All rats were killed 60 days after having treatment, and bone loss of the lumbar spine was measured by dual-energy X-ray absorption. The bone mineral density was decreased by 25.4% in control group and 23.6% in pretreatment group compared to sham group, but restored by 86% and 96% in groups treated with 100 and 200 mu g/kg/day misoprostol, respectively. These results suggest that misoprostol restores bone loss in the lumbar spine of OVX rats in a dose-dependent manner. (C) 1999 Elsevier Science Inc. All rights reserved.
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    Effects of misoprostol on lipoprotein (a) levels of ovariectomized rats
    (Elsevier Science Inc, 1999) Sonmez, AS; Birincioglu, M; Turkoz, Y; Adam, B; Lurie, D; Chuong, CJ
    Objective: To determine the effects of misoprostol on plasma lipoprotein (a) concentrations of ovariectomized rats. Design: Controlled prospective study. Setting: Animal research laboratory. Animal(s): Four-month-old female Sprague-Dawley rats. Intervention(s): Blood samples were obtained before and 60 days after ovariectomy, and the rats were divided into three groups. Group I (five rats) was treated with vehicle (water); groups II and III (nine and eight rats, respectively) were treated with oral misoprostol at 100 and 200 mu g/kg/d, respectively, for 60 days, after which blood was drawn again. Main Outcome Measure(s): Serum lipoprotein (a) levels. Result(s): The median lipoprotein (a) level before ovariectomy was 10.8 mg/dL (range, 10.6-46.5 mg/dL). Sixty days after ovariectomy, the level increased significantly to 15.9 mg/dL (range, 10.6-36.9 mg/dL). After treatment, there was no change in lipoprotein (a) levels in the vehicle-treated group (range, 16.3-21.1 mg/dL); however, the lipoprotein (a) levels decreased significantly in the group treated with 100 mu g/kg/d of misoprostol, from 15.4 mg/dL to 10.8 mg/dL, and in the group treated with 200 mu g/kg/d of misoprostol, from 17.1 mg/dL to 10.6 mg/dL. Conclusion(s): Misoprostol caused a significant decrease in lipoprotein (a) levels. (Fertil Steril(R) 1999;72: 518-21. (C) 1999 by American Society for Reproductive Medicine.) 518.