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Öğe Inflammation-driven pathogenesis of hyperemesis gravidarum: assessing the role of pan-immune-inflammation value and hematologic parameters(Springer Heidelberg, 2025) Cicek, Sevil; Coskun, Ebru Inci; Abdurahmanova, Nuray; Yilmaz, ErcanObjective Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting during pregnancy that frequently leads to hospitalization and significant maternal morbidity. Despite its clinical significance, the pathogenesis of HG remains poorly understood, with systemic inflammation emerging as a possible contributing factor. The aim of this study was to investigate the role of novel inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV), in the pathophysiology of HG and their association with disease severity. Materials and methods This retrospective case-control study included 259 pregnant women (159 with HG and 100 healthy controls) enrolled in Inonu University School of Medicine between January 2020 and August 2023. Hematologic parameters, including leukocyte, neutrophil, lymphocyte, and platelet counts and ketonuria levels, were collected from electronic medical records. Inflammatory indices (NLR, PLR, SII, and PIV) were calculated and their diagnostic performance was evaluated using receiver-operating characteristic (ROC) curve analysis. Logistic regression was used to assess the risk factors for HG. Statistical analyses were performed using SPSS version 22, with p < 0.05 considered significant. Results The HG group had significantly higher NLR (p = 0.004), PLR (p = 0.003), SII (p < 0.001), and PIV (p < 0.001) compared to controls. ROC analysis revealed that NLR [cut-off: 5.67, area under the curve (AUC) 0.608, 95% confidence interval (CI) 0.545-0.668, p = 0.002], PLR (cut-off: 154.5, AUC 0.610, 95% CI 0.547-0.669, p = 0.002), SII (cut-off: 948.4, AUC: 0.636, 95% CI 0.575-0.695, p < 0.001), and PIV (cut-off: 866.51, AUC 0.637, 95% CI 0.575-0.696, p < 0.001) showed moderate diagnostic performance with high specificity (70-94%) but variable sensitivity (25.8-55.3%). Logistic regression identified low gestational age and increased platelet distribution width (PDW) as significant risk factors for HG (p < 0.05), while PIV and other inflammatory markers did not emerge as independent predictors. Conclusion This study emphasizes the role of systemic inflammation in HG as evidenced by increased inflammatory indices in HG patients. NLR, PLR, SII, and PIV prove to be promising diagnostic markers for HG and offer high specificity and sensitivity. However, their lack of correlation with ketonuria suggests that inflammation alone cannot fully explain the severity of the disease. These findings highlight the need for further research to validate these markers and explore their potential for the development of personalized treatment strategies for HG.Öğe Investigation of social support perceptions and mental health of postpartum women following the February 6, 2023 Turkey earthquake: a comparative study(Springer, 2025) Sehlikoglu, Seyma; Bekircan, Esra; Cicek, Sevil; Kurt, Osman; Yildiz, Sevler; Simsek, Yavuz; Emir, Burcu SirlierNatural disasters, such as earthquakes, have significant psychological consequences, particularly for vulnerable populations like postpartum women. This study aimed to determine the relationship between perceived social support and mental health among postpartum women who had experienced an earthquake. In this comparative cross-sectional study, the case group (n = 62) consisted of women who were in their third trimester at the time of the earthquake and gave birth after the disaster, while the control group (n = 62) comprised women who were also in their third trimester during the earthquake and had given birth but were not residing in the earthquake-affected region and had no prior experience of an earthquake. The study did not include individuals with intellectual disabilities, illiteracy. Data were collected using the Sociodemographic data form, the Edinburgh Postnatal Depression Scale, the Multidimensional Scale of Perceived Social Support (MSPSS), the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5), and the Post-Traumatic Growth Inventory (PTGI). The incidence rates of Posttraumatic Stress Disorder (40.3%) and Edinburgh Postnatal Depression Scale (43.5%) in postpartum women who experienced the earthquake were significantly higher than those in women who did not (Posttraumatic stress disorder: 6.5%, Edinburgh Postnatal Depression Scale: 16.1%) (p <.001). The mean total MSPSS score of postpartum women who experienced the earthquake (61.7 +/- 16.9) was significantly higher than that of those who did not (51.9 +/- 13.2) (p <.001). The mean PTGI total score in postpartum women who experienced the earthquake (69.0 +/- 19.2) was significantly higher than in the control group (57.3 +/- 20.0) (p <.001). In postpartum women who experienced the earthquake, there was a significant positive correlation between PTGI and MSPSS scores, and between PCL-5 and Edinburgh Postnatal Depression Scale scores (p <.001). Pregnant women who experienced the earthquake had significantly higher posttraumatic stress disorder and postpartum depression scores compared to those who did not. It was concluded that perceived social support may promote posttraumatic growth in women who have experienced a postpartum earthquake.Öğe Investigation of social support perceptions and mental health of postpartum women following the February 6, 2023 Turkey earthquake: a comparative study (Vol 44, pg 13887, 2025)(Springer, 2025) Sehlikoglu, Seyma; Bekircan, Esra; Cicek, Sevil; Kurt, Osman; Yildiz, Sevler; Simsek, Yavuz; Emir, Burcu Sirlier[No abstract available]
