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Öğe The beneficial effects of fish oil following cisplatin-induced oxidative and histological damage in liver of rats(Iranian Journal of Pharmaceutical Research, 2017) Ciftci O.; Onatb E.; Cetinc A.This study investigated the protective effect of fish oil (FO) on cisplatin (CP) toxicity in the rat liver. Twenty-eight rats were divided equally into four groups, with the first being a control group. The second group (CP group) was given 7 mg/kg of CP and the third group (FO group) was given 1 FO softgel/rat/day for 14 days. The rats in the fourth group (CP + FO group) were treated with both CP and FO at the above doses. CP treatment caused significant oxidative damage via an increase in thiobarbituric acid reactive substances (TBARS) and reduced antioxidant defenses through a decrease in the activities of catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), and glutathione peroxidase (GPx) in rat liver tissue. Also, CP caused histopathological abnormalities, including necrosis, in the liver tissue. However, concurrent FO treatment prevented the negative oxidative and histopathological effects of CP. In conclusion, CP treatment can cause hepatotoxicity in rats, but dietary supplementation with FO can attenuate the oxidative and histological changes caused by CP. Thus, FO may be useful in preventing CP-induced hepatotoxicity in cancer patients. © 2017 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services.Öğe Complete atrioventricular block caused by mad honey intoxication.(2012) Oguzturk H.; Ciftci O.; Turtay M.G.; Yumrutepe S.The honey produced by the bees fed on Rhododendron family plants containing grayanotoxin is known as mad honey in our country. This intoxication is seen rarely. However, it may lead life-threatening hemoinstability mentioned above and may be confused with various diseases. For these reasons the exact diagnosis and treatment of this intoxication seems very important. We aim to describe a case admitted to the Emergency Department in consequence of mad honey intoxication and treated and discharged after hypotension and complete atrioventricular block development.Öğe Does 3-G mobile phone radiofrequency affect oxidative stress, sperm characteristics and testis histology?(2011) Oguzturk H.; Beytur A.; Ciftci O.; Turtay M.G.; Samdanci E.; Dilek O.F.This study aims to investigate the effects of electromagnetic radiation (EMR) delivered by mobile phones on oxidative stress, histological damage and sperm characteristic in rats. For this purpose, 18 male rats (9 in the study group and 9 in the control group) were used. The rats in experimental group were exposed to EMR from an active (1.9-2.2 GHz) mobile phone (MP) for 20 min per day for 20 days. The rats in control group were exposed to an MP without a battery for the same period. The results showed that there was no significant differences in oxidative stress parameters (TBARS, GSH, SOD, CAT, GSH-Px), testis histology and reproductive organ weight (testis, epididymis, prostate weight) between the control and the study groups. On the other hand, it was observed that the use of MPs may have negative effects on the sperm characteristics (especially sperm motility) in rats. In conclusion, it was suggested that the exposure of EMR caused a decrease of fertility capacity due to their effects on sperm characteristics. © by PSP.Öğe Lycopene prevents experimental priapism against oxidative and nitrosative damage(Verduci Editore, 2014) Ciftci O.; Oguz F.; Beytur A.; Polat F.; Altintas R.; Oguzturk H.OBJECTIVE: Priapism is a persistent and often painful penile erection in the absence of sexual stimulation. It can cause progressive fibrosis, edema and drying of the erectile tissue and then it can lead to erectile dysfunction. Previous studies suggested that, neu-ronal nitric oxide levels increased during the pri-apism. High NO levels can result in the formation of reactive oxygen species (ROS) leading to oxidative stress in tissue and reproductive system. The aim of this study was to evaluate oxida-tive and nitrosative effects caused by priapism in cavernosal tissue and serum, and determinate beneficial effects of lycopene on ischemic pri-apism. MATERIALS AND METHODS: 32 rats were randomly divided into four groups and the first group being as the control. In the second group, experimental ischemic priapism was formed for an hour and then 1hour reperfusion was provided. In the third group, lycopene was intraperi-toneally given at the dose of 10 mg/kg. In the fourth group, lycopene were administered to rats with experimental priapism. RESULTS: Priapism caused a significant increase in TBARS (thiobarbituric acid reactive substances) and NO levels and a significant decrease in the levels of GSH, CAT, GPx and SOD in serum and cavernosal tissue of rats. However, lycopene significantly increased GSH, CAT, GPx and SOD levels but decreased formation of TBARS production and NO in rats with priapism. CONCLUSIONS: Our findings indicated that is-chemic priapism lead to significant oxidative and nitrosative damage in cavernosal tissue and serum samples of rats. However lycopene treatment eliminates these negative effects induced by priapism. For this reason, we suggested that lycopene may be used in the treatment of pri-apism.
