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Öğe THE EFFECT OF MELATONIN ON THE EXPERIMENTALLY PRODUCED ALZHEIMER IN RATS AND RELATIONSHIP WITH FEZ1 GENE EXPRESSION(Wiley, 2017) Demir, M.; Yilmaz, U.; Sandal, S.; Colak, C.; Cigremis, Y.; Tekedereli, I.[Abstract Not Available]Öğe EFFECTS OF INTRACEREBROVENTRICULAR FGF21 INFUSION ON THE ENERGY METABOLISM(Wiley, 2017) Yilmaz, U.; Tekin, S.; Demir, M.; Cigremis, Y.; Sandai, S.[Abstract Not Available]Öğe In vitro antimicrobial and antioxidant activity of acetone and methanol extracts from Thymus leucotrichius (Lamiaceae)(Verduci Publisher, 2011) Ulukanli, Z.; Cigremis, Y.; Ilcim, A.Background and Objectives: Thymus species has been used as tonic and herbal tea, antiseptic, antitussive, carminative, antioxidant, anti-inflammatory and antimicrobial activities. The acetone and methanol extracts of Thymus (T.) leucotrichius (Labiatae/Lamiaceae) was examined for antimicrobial and antioxidant properties. Materials and Methods: The antioxidant properties of acetone and methanol extracts of Thymus leucotrichius were investigated using 1,1-diphenyl-2-picrylhydrazyl (DPPH)/nitric oxide (NO) radical scavenging activity, reducing power and total phenolic substance analysis. Antibacterial, antiyeast and antifungal activity of the plant extracts were tested using the disc diffusion method. Results and Discussion: Results showed that IC50 of Thymus leucotrichius acetone and methanol extracts that scavenged 50% of the DPPH radical in the medium was found to be 109.72 mu g/ml, 43.53 mu g/ml, respectively. It was found that IC50 of Thymus leucotrichius acetone and methanol extracts which scavenged 50% of the NO radical in the medium was 180.56 mu g/ml, and 67.34 mu g/ml, respectively. In the Thymus leucotrichius acetone and methanol extracts (1 mg), 35.64 mu g and 51.78 mu g pyrocatechol equivalents of phenols were detected, respectively. Neither acetone nor methanol extract possessed activity towards Proteus vulgaris, Rhodotorula rubra, Candida albicans, Aspergillus parasiticus and Aspergillus niger. Acetone extract was the most active on Bacillus cereus and Bacillus megaterium. The sentivity was also observed against towards Escherichia coli H7:O157, Kluvyeromyces fragilis and Fusarium proliferatum when acetone extract used. The methanol extract also displayed more or less similar inhibitory activity towards the test microorganisms. Kluvyeromyces fragilis was resistant to methanol extract of the species unlike acetone extracts of the species. However, the fungus Fusarium proliferatum was markedly inhibited by the methanol extract of test species at 1000 mu g and above. Significant inhibitory activities of the two extracts were based upon the increasing dose-dependent level.Öğe In vitro antioxidant and antimicrobial assays of acetone extracts from Nepeta meyeri Bentham(Verduci Publisher, 2010) Cigremis, Y.; Ulukanli, Z.; Ilcim, A.; Akgoz, M.Background and Objectivies: Nepeta species are used as diuretic, diaphoretic, antitussive, antispasmodic, antiasthmatic, febrifuge, emmenagogue, sedative agents, insecticidal, acaricidal, antiviral, anti-inflammatory and antioxidant. Acetone extract of Nepeta meyeri (Labiatae) was screened for antioxidant and antimicrobial activities. Materials and Methods: The antioxidant properties of the extract were investigated by using various methods established in vitro systems such as 1,1-diphenyl-2-picrylhydrazyl (DPPH)/nitric oxide (NO) radical scavenging activity. Reducing power and total phenolic substance analysis and also antimicrobial activity of acetone extract of Nepeta meyeri were tested against six gram negative, seven gram positive bacteria and the yeast strain using the disc diffusion method. Results and Discussion: Acetone extract of the plant examined exhibited a significant concentration-dependent inhibition of DPPH and NO center dot radical. Furthermore, Nepeta meyeri showed very high reducing power. In DPPH radical and NO center dot scavenging assays the IC50 value of extract was 672.2 mu g/ml and 165.32 mu g/ml, respectively. The amounts of total phenolic compounds were also determined and 12.86 mu g pyrocatechol equivalents of phenols were detected in the extract. The data obtained from these in vitro models clearly demonstrated antioxidant potential of acetone extract of Nepeta meyeri. The extract revealed antibacterial activity against all gram positive bacteria but not was active against gram negative bacteria.Öğe The inhibitory effect of Resveratrol on experimental endometriosis via nuclear factor kappa B-independent pathway(Oxford Univ Press, 2012) Simsek, Y.; Celik, O.; Cigremis, Y.; Akgoz, M.; Ozerol, E.; Tanbek, K.; Turhan, U.[Abstract Not Available]Öğe Is there a new pathway relationship between melatonin and FEZ1 in experimental rat model of Alzheimer's disease?(Comenius Univ, 2019) Demir, M.; Yilmaz, U.; Colak, C.; Cigremis, Y.; Ozyalin, F.; Tekedereli, I; Sandal, S.Alzheimer's disease (AD) is a progressive neurodegenerative disease. This study was performed to determine the possible relationship between melatonin, which is known to play a role in the neuro-protective mechanism in AD, and fasciculation and elongation protein zeta 1 (FEZ1). Thirty male rats were included and separated into 3 groups (n = 10) as vehicle (artificial cerebrospinal fluid), streptozotocin (STZ) and STZ+melatonin (MLT). Two intracerebroventricular (icv) injections of 3 mg/kg STZ were made 48 hours apart. MLT injections were implemented for 14 days (ip; 10mg/kg/day). The Morris Water Maze (MWM) test was performed and rats were sacrificed to assess FEZ1 gene expression and protein levels from the hippocampus tissues and serum levels of noradrenaline (NA), dopamine and serotonin were determined from the blood samples. It was determined that the FEZ1/beta-actin protein ratio in the STZ group was significantly higher than that of the Vehicle group (p < 0.05) and in the MLT-administered group, the protein levels were decreased to the levels observed in the Vehicle group. Serum NA levels of STZ and STZ+MLT groups were found to be lower than those in the Vehicle group, while no difference was found regarding dopamine and serotonin levels. These findings show that reversal of increased FEZ1 levels in AD-induced rats with melatonin administration is the evidence of the effect of melatonin through FEZ1 in AD (Tab. 2, Fig. 5, Ref. 67).Öğe Nitric oxide concentrations, estradiol-17? progesterone ratio in follicular fluid, and COC quality with respect to perifollicular blood flow in cows(Elsevier Science Bv, 2012) Pancarci, S. M.; Ari, U. C.; Atakisi, O.; Gungor, O.; Cigremis, Y.; Bollwein, H.The objectives were to investigate relationships among concentrations of nitric oxide (NO), estradiol 17 beta (E2), and progesterone (P4) in follicular fluids (FF), and quality of cumulus oocyte complexes (COCs) with respect to perifollicular blood flow (FBF). In Experiment I. follicles (138) were classified according to the presence or absence of FBF (assessed with transvaginal Doppler ultrasonography) and diameter of follicles (small, 2-4 mm; medium, 5-8 mm; and large, >= 9 mm). Concentrations of NO in FF did not differ significantly among these size categories. However, NO concentrations in FF with FBF (54.4 +/- 7.4 mu mol/l) were higher (P < 0.05) than in those without FBF (36.6 +/- 4.1 mu mol/l). There was a positive correlation (r = 0.30, P < 0.05) between NO concentrations and the E2:P4 in FF. Rate of E2 active (E2:P4 >= 1) follicles were numerically 1.2(0.8-1.8) times higher in follicles with FBF (38.1%) compared to those without FBF (25.0%). Moreover, rates of E2 active follicles were 6.1 (0.7-55.2) and 1.3 (0.1-17.3) times higher (P < 0.06) in large (43.3%) and medium (14.3%) compared to small follicles (11.1%), respectively. In Experiment II, quality of COCs from 2 to 8 mm follicles, obtained by transvaginal ovum pick up (OPU), was investigated with respect to FBF. Odds ratio to obtain higher quality COCs from follicles with FBF (47.1%) was 3.3 (1.1-9.6) fold higher (P < 0.05) compared to those from follicles without FBF (14.6%). In conclusion, E2:P4, and NO concentrations in FF, as well as FBF, could be used to determine the functionality of ovarian follicles in cows. Moreover, determination of FBF could be useful to predict quality of COCs in cattle. (C) 2012 Elsevier B.V. All rights reserved.Öğe Prokineticin 1 leukemia inhibitory factor and Dickkopf 1 mRNA expression in the endometrium of women with unexplained infertility and idiopathic recurrent pregnancy loss(Oxford Univ Press, 2014) Karaer, A.; Cigremis, Y.; Celik, E.; Gonullu, R.[Abstract Not Available]Öğe Protective effect of short-term thymoquinone administration on the central nervous system in cisplatin-induced neurotoxicity(Verduci Publisher, 2022) Durak, M. A.; Ozhan, O.; Yildiz, A.; Durhan, M.; Vardi, N.; Cigremis, Y.; Parlakpinar, H.OBJECTIVE: This study was performed to investigate the potential benefi- cial effects of thymoquinone (TQ) on brain tis-sue based on biochemical and histopathologi-cal analyses in cisplatin (CIS) treated rats with central nervous system (CNS) neurotoxicity. MATERIALS AND METHODS: The rats were randomly divided into 4 groups with 8 rats in each group (n:8). Group 1: (Control), saline was administered for 3 days at a volume of 0.5 ml per day intraperitoneal (i.p.). Group 2: (CIS Group), one dose of CIS was administered (7 mg/kg i.p.). Group 3: (TQ Group), TQ was giv-en at a dose of 5 mg/kg per day for 3 days (i.p.). Group 4: (CIS+TQ Group), one dose of 7 mg/ kg was initiated half an hour before adminis-tration of CIS and one dose of 5 mg/kg per day was administered TQ i.p. for 3 days. RESULTS: Malondialdehyde levels were found to be statistically significantly higher in the CIS group compared to the control group. Degenerative changes observed in the CIS+TQ group were found to be milder than in the CIS group. In the CIS+TQ group, a statistically sig-nificant decrease in the severity of caspase-3 immunoreactivity was found when compared to the CIS group. It was found that the sever-ity of neurofilament immunoreactivity moni- tored in neuronal extensions was similar in all groups. In the CIS+TQ group, the severity of tau protein's immunoreactivity was similar to that of the CIS-group.CONCLUSIONS: According to the results obtained in our study, beneficial effects were obtained in reducing neurotoxicity with short-term TQ application in rats treated with CIS treatment.Öğe Protective effects of saffron (its active constituent, crocin) on nephropathy in streptozotocin-induced diabetic rats(Sage Publications Ltd, 2015) Altinoz, E.; Oner, Z.; Elbe, H.; Cigremis, Y.; Turkoz, Y.The reactive oxygen species take role in pathogenesis of many diseases including hypoxia, hypercholesterolemia, atherosclerosis, nephropathy, hypertension, ischemia-reperfusion damage, and heart defects. The aim of this study was to evaluate whether crocin administration could protect kidney injury from oxidative stress in streptozotocin-induced diabetic rats. The rats were randomly divided into 3 groups each containing 10 animals as follows: group 1, control group; group 2, diabetes mellitus (DM) group; and group 3, DM + crocin group. At the end of the study, trunk blood was collected to determine the plasma levels of blood urea nitrogen (BUN) and creatinine (Cr). The kidney tissue was removed, and biochemical and histological changes were examined. Diabetes caused a significant increase in malondialdehyde (MDA) and xanthine oxidase (XO) activities and a decrease in glutathione (GSH) contents (p < 0.01) when compared with control group in the rat kidneys. Crocin given to DM rats significantly decreased MDA (p < 0.01) and XO (p < 0.05) activities and elevated GSH (p < 0.05) contents when compared with DM group. Plasma levels of BUN and Cr were significantly higher in the DM group when compared with the control group (p < 0.01). Pretreatment of the DM animals with crocin decreased the high level of serum Cr and BUN. Control group was normal in histological appearance, but congestion, severe inflammation, tubular desquamation, tubular necrosis, and hydropic degeneration in tubular cells were observed in the DM group. Histopathological changes markedly reduced, and appearance of kidney was nearly similar to control group in DM + crocin group. Our results show that crocin could be beneficial in reducing diabetes-induced renal injury.
