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    Evaluation of endothelial function in subclinical hypothyroidism and subclinical hyperthyroidism
    (Mary Ann Liebert, Inc, 2004) Cikim, AS; Oflaz, H; Ozbey, N; Cikim, K; Umman, S; Meric, M; Sencer, E
    Subclinical hypothyroidism and subclinical hyperthyroidism are two frequently occurring conditions for which exact therapeutic approaches have not yet been established. The aim of this study was to compare the endothelial function and carotid artery intimae-media thickness (IMT) of these two groups of patients to euthyroid subjects and to assess the effects of these conditions on endothelial function. Study groups comprised of 25 subclinical hypothyroid patients (mean age, 32.28 +/- 9.67 years), 13 subclinical hyperthyroid patients (mean age, 35.69 +/- 9.67 years), and 23 euthyroid subjects (mean age, 35.87 +/- 7.93 years). They were evaluated for flow-mediated dilatation (FMD), and carotid artery IMT. The groups were matched strictly for atherosclerotic risk factors. The subclinical hypothyroid group was found to have significantly lower FMD values. No significant differences were observed between the groups with respect to other vascular parameters. The only discriminative factor between the groups was the state of their thyroid function. Therefore, subclinical hypothyroidism may have adverse effects on endothelial function independent from other well-known atherosclerotic risk factors.
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    Pathologic hepatic Tc-99m-MDP uptake in polyostotic fibrous dysplasia
    (Springer, 2004) Kekilli, E; Yagmur, C; Kuzucu, A; Soysal, O; Cikim, AS; Ertem, K
    Fibrous dysplasia of bone is a congenital, sporadic developmental disorder characterized by immature fibrous connective tissue and bone deformities. Hepatic Tc-99m-MDP uptake is a rare, serendipitous finding during bone scanning studies. The present patient was a 25-year-old male who had severe polyostotic fibrous dysplasia. On Tc-99m-MDP (methylene diphosphonate) bone scintigraphy, increased activity accumulations were seen on multiple ribs, vertebrae and base of the cranium. In addition, diffuse increased pathologic uptake of Tc-99m-MDP in the liver was shown. Intravenous pamidronate was administered monthly for two months. In the third week of the last administration Tc-99m-MDP bone scintigraphy was performed again, but despite sustained bone involvement, pathologic hepatic uptake was not seen on the scan. We thought that pathologic hepatic Tc-99m-MDP accumulation, may be related to the formation and aggregation of calcium oxalate and phosphate crystals which improved with pamidromat treatment.
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    Relationship between cardiovascular risk indicators and types of obesity in overweight and obese women
    (Cambridge Med Publ, 2004) Cikim, AS; Ozbey, N; Orhan, Y
    We aimed to evaluate the relationship between different types of obesity and cardiovascular risk indicators. A total of 623 overweight (body mass index [BMI] > 25 kg/m(2)), and 2559 obese (BMI > 30 kg/m(2)) women were divided into four groups according to their BMI and waist-to-hip ratio (WHR): simple overweight (BMI 25 - 30 kg/m(2) and WHR < 0.8, n = 371), abdominal adiposity (BMI 25 - 30 kg/m(2) and WHR > 0.8, n = 252), peripheral (pure) obesity (BMI > 30 kg/m(2) and WHR < 0.8, n = 918) and central obesity (BMI > 30 kg/m(2) and WHR > 0.8, n = 1641). The levels of the risk indicators measured (clinical, anthropometric and laboratory) were significantly higher in the central obesity group. Total body fat and abdominal fat accumulation seems to result in more serious hyperinsulinaemia and insulin resistance in central obesity. Measuring BMI and WHR in obese patients may reveal their risk for coronary heart disease.