Yazar "Cinar, Vedat" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim Yok
    Öğe
    Core Exercise as Non-Pharmacological Strategy for Improving Metabolic Health in Prediabetic Women
    (Mdpi, 2025) Yigiter, Nuray; Akcinar, Faruk; Yasul, Yavuz; Cinar, Vedat; Akbulut, Taner; Migliaccio, Gian Mario
    Background and Objectives: Prediabetes (PD) is characterized by impaired glucose metabolism and is associated with an elevated risk of type 2 diabetes and cardiovascular diseases. This study aimed to investigate the effects of an 8-week core exercise intervention on glycemic control, lipid profiles, insulin sensitivity, body composition, and physical performance in prediabetic women. Materials and Methods: Eighteen prediabetic women aged 20-55 years were randomly allocated to either a core exercise group (n = 9) or a control group (n = 9). The intervention group completed 24 supervised core exercise sessions over 8 weeks, whereas the control group remained sedentary. Pre- and post-intervention evaluations included anthropometric measurements, flexibility and strength tests, fasting and postprandial glucose levels, HbA1c, insulin, HOMA-IR, lipid profiles, and serum iron levels. Non-parametric tests were used for statistical analysis, and a Principal Component Analysis (PCA) and hierarchical clustering were conducted to explore multidimensional metabolic changes. Results: Core exercise significantly improved the body weight, BMI, fat percentage, and circumferences (shoulder, chest, and hip), along with an enhanced flexibility and back-leg strength (p < 0.05). Glycemic indices (FBG, PBG, and HbA1c), insulin, and HOMA-IR levels were significantly reduced, while serum iron and HDL-C increased (p < 0.05). Lipid markers, including the TG, LDL-C, CHOL, and TG/HDL-C ratio, showed significant improvements. The PCA and cluster analyses identified three clusters reflecting metabolic risk, body composition, and protective factors. Conclusions: This study demonstrates that an 8-week structured core exercise program significantly improves glycemic control, lipid profiles, insulin sensitivity, and body composition in women with prediabetes. Multivariate analyses (PCA and hierarchical clustering) corroborate a metabolic shift towards a reduced insulin resistance and a more favorable cardiometabolic profile, supporting core training as a viable, evidence-based non-pharmacological intervention to mitigate metabolic risk.
  • Küçük Resim Yok
    Öğe
    The Effect of Vitamin D3 Supplement with Football Training on Glucose, Insulin, Cortisol and ACTH Levels: Vitamin Supplement Study
    (Lahore Medical Research Center Llp, 2021) Pancar, Zarife; Cinar, Vedat; Aydemir, Isa; Bulguru, Bedrettin
    Background: Vitamin D-3 has an important role in the development of the musculoskeletal system, the protection of bone health and the effective functioning of the neuromuscular systems. Aim: In this study, it was aimed to investigate the effects of vitamin D-3 supplementation on glucose, insulin, cortisol and ACTH hormone given to young football players during four weeks in addition to training. Methods: 14 male volunteer athletes participated in the study. They were randomly divided into two groups as the control group (n:7) who continued their football training 5 days a week for four weeks, and the application group that received vitamin D-3 supplements in addition to football training (n:7). Resting blood samples were taken from the athletes participating in the study one day before and one day after the training and reinforcement applications. Glucose, insulin, cortisol and ACTH values were determined in the blood samples taken. Paired Samples t test was applied to determine the changes occurring within the group. Results: As a result of the analysis, there was no statistically significant difference between the glucose, insulin, cortisol and ACTH pre-test and post-test levels of the control group (p> 0.05), while the glucose and insulin levels of the group given vitamin D-3 supplement were found to be significantly different (p <0.05). In the intergroup analysis of the groups in terms of pre-test and post-test values, no significance was found in glucose, insulin, cortisol and ACTH values (p> 0.05). Conclusion: As a result of the research, it was found that vitamin D-3 supplementation applied in addition to football training caused differences in insulin and glucose levels among the biochemical parameters of young football players; It is thought that the use of D-3 together with exercise will produce results that improve public health and athlete performance.
  • Küçük Resim Yok
    Öğe
    Investigation of Iris, Leptin, Ghreline and Some Hormonal Responses of the Strength Training Program Applied to Handball Players
    (Lahore Medical Research Center Llp, 2021) Turgut, Mine; Cinar, Fidan; Dundar, Aykut; Yasul, Yavuz; Cinar, Vedat; Yamaner, Yusuf Burak
    Background: The effects of exercise on physiological systems were an inevitable truth. Especially the relationship of exercise with the endocrine system was one of the important focuses of interest. Irisin, Seratonin, Melatonin, Leptin, Ghrelin and Apelin hormones, which become a ball of interest recently, were the subjects that researchers follow and work with great interest. Aim: This study aimed to determine the effect of strength training program applied to handball players on the Irisin, Seratonin, Melatonin, Leptin, Ghrelin and Apelin hormones. Method: 24 healthy male handball players between the ages of 18-24 participated in the study. Participants were randomly divided into two groups (control and experimental). While handball training was applied to the first group (control) for 6 weeks, strength training was applied to the second group (experimental). The blood samples of the participants were taken on an empty stomach in the morning by experts in the appropriate laboratory environment before the training at rest, according to the pre-test and post-test model. In the analysis of the data, descriptive statistics (mean, standard deviation) and Shapiro Wilk test, kurtosis, steepness and histogram graph were taken into consideration to test the normality of the distribution before starting the analysis, and it was observed that the distribution was normal. In this context, Paired Samples t-test was used to reveal intra-group differences and the Independent samples t-test statistical techniques were used to reveal differences between groups. The level of significance was set at 0.05 and the analyses were made in the Windows SPSS 22 package program. Results: It was observed that irisin, apelin and ghrelin levels increased in the experimental group of the strength training program applied with the obtained results, it did not change in the control group. It was determined that the serotonin level increased in both the strength training group and the control group. While it was observed that the leptin level decreased in the Strength group, it did not change in the control group, and it was understood that the melatonin level did not undergo any change in both the experimental and control groups. Conclusion: As a result, it was concluded that the 6-week strength training protocol applied to athletes caused significant changes in irisin, apelin, ghrelin, serotonin, leptin levels of handball players, but did not show any change in melatonin levels.
  • Küçük Resim Yok
    Öğe
    Moderate/High-Intensity Exercise and Coenzyme Q10 Supplementation May Reduce Tumstatin and Improve the Lipid Dynamics and Body Mass in Rats
    (Mdpi, 2025) Yasul, Yavuz; Akcinar, Faruk; Cinar, Vedat; Akbulut, Taner; Aydemir, Isa; Yalcin, Mehmet Hanifi; Avcu, Emsal cagla
    Coenzyme Q(10) (CoQ(10)) is a molecule that serves as a coenzyme for mitochondrial enzymes, playing a fundamental role in mitochondrial bioenergetics as an electron and proton carrier in the energy production process. This study aimed to examine the modulatory effects of moderate/high-intensity exercise and CoQ(10) supplementation on tumstatin, lipid dynamics, and body mass in rats. This study used 42 male Wistar Albino rats in six groups: a control group (C), a moderate-intensity continuous training group (MICT), a high-intensity continuous training group (HICT), a coenzyme Q(10) group (Q(10)), a moderate-intensity continuous training combined with Q(10) group (MICTQ(10)), and a high-intensity continuous training combined with Q(10) group (HICTQ(10)) to assess the effects of exercise and 5 mg/kg/daily CoQ(10) supplementation. Rats underwent treadmill training, and tumstatin levels in plasma, cardiac, and skeletal muscle tissues were measured using ELISA and immunostaining techniques. In addition to the plasma, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC) levels were analyzed using enzymatic methods, with the LDL-C calculated using the Friedewald equation. The atherogenic index of plasma was determined by the TG/HDL-C ratio. As compared to group C, body mass was significantly affected by both exercise intensity and supplementation (p = 0.01, eta(2) = 0.37), with the MICTQ(10) and HICTQ(10) groups demonstrating the greatest reductions by day 50th (p = 0.0003, d = 4.02; p = 0.0001, d = 3.99). Lipid profiles varied significantly between groups. Compared to the C group, the MICTQ(10) group exhibited the most substantial decreases in LDL-C (p = 0.03, d = 2.35) and TG levels (p = 0.03, d = 2.25), while the HICTQ(10) group showed the most pronounced reduction in TC levels (p = 0.001, d = 6.41). Regarding tumstatin levels, skeletal muscle tumstatin levels were lowest in the HICTQ(10) group (p = 0.01, d = 2.11). Moreover, cardiac muscle tumstatin levels were significantly lower in the MICTQ(10), MICT, and HICTQ(10) groups compared to in the C group (p = 0.004, d = 1.01). These findings suggest that both exercise intensity and CoQ(10) supplementation exert notable physiological effects, particularly in modulating body mass, lipid metabolism, and tumstatin levels.