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    Effect of nebivolol on liver regeneration in an experimental 70% partial hepatectomy model
    (Elsevier Singapore Pte Ltd, 2017) Sumer, Fatih; Colakoglu, Muhammet Kadri; Ozdemir, Yilmaz; Ozsay, Oguzhan; Ilter, Ozer; Bostanci, Erdal Birol; Akoglu, Musa
    Background: Factors affecting liver regeneration are still relevant. The purpose of this study is to investigate the effect of nebivolol treatment on liver regeneration in rats in which 70% partial hepatectomy was performed. Methods: Three groups were created: the control group, the low dose group, and the high dose group, with 20 rats in each group and 70% hepatectomy was performed in all rats. Immediately after partial liver resection, 2 mL physiological saline solution was administered to the control group via oral gavage, 0.5 mg/kg nebivolol was administered via oral gavage to the low dose group and 2 mg/kg nebivolol was administered via oral gavage to the high dose group. On the 1st and 5th days after liver resection, 10 subjects were sacrificed from each group, and liver weights and the mitotic count and Ki-67 were measured. Results: Regenerating liver weight on the 1st and 5th days after partial hepatectomy was statistically different in the low dose and high dose nebivolol groups compared to the control group. Mitotic count on the 1st day after partial hepatectomy was significantly higher in the low dose and high dose nebivolol groups than the control group. There was no statistically significant difference detected between the three groups for the 5th day. On the 1st day, Ki-67 rates were significantly higher in both groups given nebivolol than the control group. However, 5th day results were not statistically significant. Conclusion: Nebivolol increases regeneration after partial hepatectomy in rats. (C) 2016 Asian Surgical Association and Taiwan Robotic Surgical Association. Publishing services by Elsevier B.V.
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    Evaluation of colonoscopy requests in an open-access endoscopy unit
    (2018) Colakoglu, Muhammet Kadri; Akdogan, Remzi; Rakici, Halil; Ayvaz, Muhammet Ali; Set, Turan
    Aim: Improper colonoscopy requests from different medical fields, especially like in an open access endoscopy unit, increases workload of the unit and healthcare expenses. For standardize these requests, eligibility criterias emerged. The aim of this study was to evaluate the appropriateness of colonoscopy requests performed in an open-access endoscopy unit of a university hospital and determine possible causes of the improper requests by patient characteristics, colonoscopy indications and results. Material and Methods: Between January 2009 and January 2015, 3259 patients who were referred for colonoscopy in an open-access endoscopy unit of a university hospital were enrolled into study. Post-procedure colonoscopy reports, along with their diagnoses, were recorded. All records were then evaluated retrospectively and the patient’s indications and patients’ results were compared and reasons for improper requests were discussed. Results: The mean age of the patients who underwent colonoscopy was 56.68 year, and 56.2% of the patients were males. When the requests were placed in order of frequency, the first three cases were rectal bleeding, anemia, and abdominal pain. Most of the patients did not have any pathology on colonoscopy (37.8%, n = 1238). The other most common diagnoses were hemorrhoids and colon polyps. Malignancy detection rate by colonoscopy was 5.3%. Associations between requests and results were detailed. Conclusion: Eligibility criterias should be used to minimize inappropriate requests and training should be provided for experts about colonoscopy these criterias, or a gastroenterologist should be consulted before colonoscopy procedure, especially for open-access endoscopy units.
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    Management of difficult gallbladder and comparison of laparoscopic subtotal cholecystectomy with open subtotal cholecystectomy
    (2019) Muhammedoglu, Bahtiyar; Sikrikci, Vehbi; Colakoglu, Muhammet Kadri; Oter, Volkan
    Aim: Laparoscopic cholecystectomy is the optimal surgical treatment for benign gallbladder diseases. Under curtain conditions it is very hard to distinguish the Calot triangle and it becomes difficult to perform safe cholecystectomy. Subtotal cholecystectomy is a salvage option in such conditions. The aim of this study is to compare the results of open and laparoscopic subtotal cholecystectomy in difficult gallbladder management.Material and Methods: In this retrospective study results of all consecutive patients who were performed subtotal cholecystectomy between July 2014 and August 2017 were collected and laparoscopic and open methods were compared. Results:Forty-five of 396 laparoscopic cholecystectomy cases underwent subtotal cholecystectomy during the study period. Subtotal cholecystectomy was performed laparoscopically in 27 of 45 patients (Group I), and open method in 18 patients (Group II). Convertion rate was %34.1. No significant difference was observed in terms of both preoperative and postoperative laboratory results. There was no difference between two groups in terms of ERCP history. The rate of open operation was statistically higher in acute cases. The duration of surgery was significantly higher in laparoscopic group but length of hospital stay was significantly higher in open group. Total cost was higher in group 2 but this result did not reach statistical significance. Total bile leak rate was 2.2%.Conclusion: Laparoscopic subtotal cholecystectomy is a safe and appropriate method which can be compared with open subtotal cholecystectomy in difficult gallbladder management.