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    New synthesized benzofuran substituted chalcones on human prostate cancer cell lines: an in vitro study
    (Wiley-Blackwell, 2015) Tekin, Suat; Coskun, Demet; Sandal, Suleyman
    [Abstract Not Available]
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    Synthesis and evaluation of benzofuran substituted chalcones on human breast cancer cell lines: An in vitro study
    (Wiley-Blackwell, 2015) Tekin, Suat; Coskun, Demet; Sandal, Suleyman
    [Abstract Not Available]
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    Synthesis of the New 1-(7-Methoxy-1-benzofuran-2-yl)-3-(4-methylphenyl)prop-2-en-1-one and Controlling of Spectroscopic, Optical and Conductivity Properties by Concentration
    (Slovensko Kemijsko Drustvo, 2022) Coskun, Demet; Coskun, Mehmet Fatih; Gunduz, Bayram
    Chalcone derivatives have an important place in science due to their different applications ranging from their semiconductor properties to biological properties. In this work 1-(7-methoxy-1-benzofuran-2-yl)-3-(4-methylphenyl)prop-2-en-1-one (2) has been prepared by condensation of 1-(7-methoxy-1-benzofuran-2-yl)ethanone with 4-methylbenzaldehyde in basic medium. The chemical structure of 2 was confirmed by elemental analysis, FT-IR, H-1 NMR and C-13 NMR. UV spectroscopic characteristics, absorption band edges, optical band gaps, refractive indices, environmental behaviors and conductivity properties of 2 in solutions at different concentrations were investigated in detail. With the concentration, we examined how the spectroscopic, optical and conductivity properties of 2 have changed and can be controlled.
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    Synthesis, Characterization, and Anticancer Activity of New Benzofuran Substituted Chalcones
    (Hindawi Ltd, 2016) Coskun, Demet; Tekin, Suat; Sandal, Suleyman; Coskun, Andmehmet Fatih
    Benzofuran derivatives are of great interest in medicinal chemistry and have drawn considerable attention due to their diverse pharmacological profiles including anticancer activity. Similarly, chalcones, which are common substructures of numerous natural products belonging to the flavonoid class, feature strong anticancer properties. A novel series of chalcones, 3-aryl-1-(5-bromo-1-benzofuran-2-yl)-2-propanones propenones (3a-f), were designed, synthesized, and characterized. In vitro antitumor activities of the newly synthesized (3a-f) and previously synthesized (3g-j) chalcone compounds were determined by using human breast (MCF-7) and prostate (PC-3) cancer cell lines. Antitumor properties of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell viability assay for the tested chalcone compounds was performed and the log IC50 values of the compounds were calculated after 24-hour treatment. Our results indicate that the tested chalcone compounds show antitumor activity against MCF-7 and PC-3 cell lines (p < 0.05).