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    Evaluation of mean platelet volume and distribution width in childhood infectious mononucleosis
    (2020) Temel, Munevver Tugba; Coskun, Mehmet Enes
    Aim: Epstein-Barr virus (EBV) is an infectious agent that affects more than 95% of the world’s population and is usually diagnosed through characteristic clinical findings, hematologic changes in complete blood counts, and atypical lymphocytes in peripheral smears. A definitive diagnosis requires serological confirmation of the EBV infection. This study intends to investigate the relationship between the mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) values, which are platelet indices that can be used as markers of inflammation in different inflammatory diseases, and the EBV-associated infectious mononucleosis (IM) disease.Material and Methods: A total of 54 patients (30 males, 24 females) with EBV-associated infectious mononucleosis diagnosed at the Department of Pediatrics, University of Gaziantep University between January 2015 and June 2017 were retrospectively analyzed. Meanwhile, 68 age and gender-matched children were involved as the control group. White blood cell (WBC), hemoglobin (Hb), MPV, PDW and PCT values were compared across the patient and control group.Results: While the MPV values of the EBV-associated IM patient group were significantly high, the PDW values were significantly low (p0.001). The mean (WBC) counts of the IM patients were higher than those of the control group (p0.001). There was no significant difference between the groups in terms of PCT, platelet and Hb values. Conclusion: According to our findings, PDW and particularly MPV may be useful markers of inflammation during EBV-associated IM.
  • Küçük Resim
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    Lactose intolerance in the differential diagnosis of uneasy infants
    (2019) Temel, Levent; Temel, Munevver Tugba; Coskun, Mehmet Enes; Demiryurek, Abdullah Tuncay
    Aim: Intestinal lactase deficiency is the most common carbohydrate malabsorption and digestive disorder. If lactase deficiency coexists with gastrointestinal symptoms such as abdominal distension, flatulence, abdominal pain, diarrhea, vomiting and nausea, then the term “lactose intolerance” is used clinically. Uneasiness and excessive crying are frequently seen in the first 3 months of life and constitute nearly 20% of the patients who are referred to a pediatrician. This study aims to perform a retrospective analysis of the complaints of patients who have been diagnosed with lactose intolerance.Material and Methods: The files of patients, who were diagnosed with lactose intolerance between October 2017 and May 2018 in Defalife Hospital Pediatrics Outpatient Clinic, were retrospectively reviewed.Results: A total of 38 patients, consisting of 23 males and 15 females are included to the study. The mean age of the patients was 5.51±3.47 months (age range 1 to 18 months). 31% of the patients diagnosed with lactose intolerance were admitted to the hospital due to uneasiness and excessive crying, and all of the patients were previously diagnosed as having infantile colic. Conclusion: This study concludes that conducting tests for lactose intolerance might be beneficial in children that are presented to the hospital due to unexplained crying after the fourth month, at which time there is an expectation of seeing an improvement in colic behavior.