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  • Küçük Resim
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    Corneal endothelial changes in long-term cannabinoid users
    (TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND, 2018) Polat, Nihat; Cumurcu, Birgül; Cumurcu, Tongabay; Tuncer, İlknur
    Purpose: The aim of this study was at evaluating the effects of long-term cannabis use on the corneal endothelial cells with the specular microscopy.Methods: The study enrolled 28 eyes of 28 patients diagnosed with cannabinoid use disorder. The cannabinoid group was selected among patients who had been using the substance for three days or more per week over the past one year. Thirty-two eyes of 32 age- and sex-matched healthy individuals enrolled as control group in the study. Corneal endothelial cell density (CD), coefficient of variation (CV) and hexagonal cell ratio (HEX) values were analyzed by specular microscopy.Results: The mean CD was 2900211 cells/mm(2) in the cannabinoid group and 3097 +/- 214 cells/mm(2) in the control group (p<0.01). There was a significant decrease in cannabinoid group. The mean CV was 29 +/- 7 and 27 +/- 4 in the cannabinoid and control groups, respectively (p>0.05). No significant difference was present between the cannabinoid and the control groups in terms of mean CV value. The mean HEX was 52 +/- 5% in the cannabinoid group and 53 +/- 10% in the control group (p>0.05). There was not a significant difference between the cannabinoid and the control groups in terms of mean HEX value.Conclusion: A significant decrease in CD was found in cannabinoid users compared the control group.
  • Küçük Resim Yok
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    Effect of the addition of ketamine to sevoflurane anesthesia on seizure duration in electroconvulsive therapy
    (The Journal of ECT., 2015) Erdil, Feray; Özgül, Ülkü; Çolak, Cemil; Cumurcu, Birgül; Durmus, Mahmut
    Objectives We evaluated the effects of a subanesthetic dose of ketamine, which was administered as an adjunct to sevoflurane, on duration of seizure activity, hemodynamic profile, and recovery times during electroconvulsive therapy in patients with major depression. Methods Patients were randomly allocated to a group receiving either sevoflurane-ketamine (group SK) or sevoflurane-saline (group SS). Sevoflurane was initiated in both groups at 8% for anesthesia induction until loss of consciousness was achieved, at which point it was discontinued. After loss of consciousness, ketamine was administered to the group SK in the form of a 0.5-mg/kg intravenous bolus. Patients in the group SS received saline in the same manner. Mean arterial pressure (MAP) and heart rate were recorded before anesthetic induction (T1); after anesthetic induction (T2); as well as 0, 1, 3, and 10 minutes after the seizure had ended (T3, T4, T5, and T6, respectively). Motor and electroencephalogram seizure durations were recorded. Results Motor and electroencephalogram seizure durations in the group SS were similar to those observed for the group SK. The heart rate increased significantly during T2 to T6 in both group SS and group SK compared with the baseline. The MAP increased in the group SS during the period between T3 and T6 as well as in the group SK during the same period compared with the baseline. The MAP increased more in the group SK, in comparison with the group SS, during T2 (P < 0.05). Conclusions The addition of ketamine at subanesthetic doses, for the purposes of anesthetic induction with sevoflurane, yielded results similar to those in the control group in terms of both seizure duration and hemodynamic stability.
  • Küçük Resim
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    Kabakulak Meningoensefaliti Sonrası Gelişen Tourette Sendromu: Bir Olgu Sunumu
    (İnönü Üniversitesi Tıp Fakültesi Dergisi, 2011) Özcan, Özlem; Yüksel, Tuğba; Cumurcu, Birgül; Güngör, Serdal
    Tourette sendromu (TS) ani, hızlı, istemsiz ve yineleyici motor-vokal tiklerle karakterize çocukluk çağı başlangıçlı nöropsikiyatrik bir bozukluk olup; etiyolojisinde immünolojik, genetik, epigenetik, hormonal ve çevresel faktörlerin rol oynayabileceği bilinmektedir. Son yıllarda A grubu B hemolitik streptekok, herpes simplex virus, varisella zoster virus, HIV, borrelia burddorferi gibi enfeksiyöz ajanlarla geçirilen enfeksiyonlardan sonra SSS tutulumuna bağlı olarak da tiklerin ortaya çıktığı ya da alevlendiği bildirilmektedir. Olgu: Bu olgu sunumunda kabakulak enfeksiyonundan yaklaşık 40 gün sonra ortaya çıkan, 2 yıldır motor ve vokal tikleri olan 12 yaşında bir erkek hastadan söz edilecektir. Sonuç: Bildirilen kabakulak sonrasında tikler gelişen ikinci olgu olması ve aripiprazol tedavisinden fayda görmesi nedeniyle bu olgu önemlidir. İkincil TS belirtileri bu önemli gelişimsel nöropsikiyatrik bozukluğu daha iyi anlamamıza katkı sağlayabilir.