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Öğe Analysis of manganese superoxide dismutase (MnSOD: Ala-9Val) and glutathione peroxidase (GSH-Px: Pro 197 Leu) gene polymorphisms in mood disorders(Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2013) Cumurcu, Birgul Elbozan; Ozyurt, Huseyin; Ates, Omer; Gul, Isil Gogcegoz; Demir, Suleyman; Karlidag, RifatWe investigated the etiopathogenetic role of manganese superoxide dismutase (MnSOD) (Ala-9Val) and glutathione peroxidase (GSH-Px) (Pro 197 Leu) gene polymorphisms in patients diagnosed with major depressive disorder (MDD) and bipolar I disorder (BD). Eighty patients with MDD, 82 patfents with BD (total 162 patients) and 96 healthy controls were enrolled in this study and genotyped using a Real Time-Quantitative Polymer Chain Reaction (RT-qPCR)-based method. The patients with BD and MDD and the controls had a similar distribution of the genotypes and alleles in the Ala-9Val MnSOD gene polymorphism. Comparison of the MDD group and control group regarding the Pro 197 Leu GSH-Px gene polymorphism revealed similar genotype distribution but different allele distribution. The BD group and control group were similar both for genotypes and for alleles when compared regarding the Pro 197 Leu GSH-Px gene polymorphism. The combined analysis (MDD plus BD) also failed to find any association between the Ala-9Val MnSOD and Pro 197 Leu GSH-Px gene polymorphism. Although small statistical power of the current study the significant difference between patients with depression and the control group for the Pro 197 Leu GSH-Px polymorphism indicates that the distribution of these alleles may have a contribution in the physiopathogenesis of depression. One of the limitation of the current study is that the sample size is too small. Understanding of the exact role of Pro 197 Leu GSH-Px polymorphism in the development of depression needs to further studies with more sample size and high statistical power. (C) 2013 Association of Basic Medical Sciences of FB&H. All rights reservedÖğe Aripiprazole-induced transient myopia(Kare Publ, 2020) Cumurcu, Tongabay; Cumurcu, Birgul Elbozan; Yesil, Bahar; Gunduz, AbuzerThis study aims to present a case of transient myopia due to aripiprazole used in the treatment of depression. A 21-year-old female who was being treated for depression with 15 mg/day Aripiprazole during two months. She normally used -3.75 D glasses. She was admitted to our outpatient clinic with sudden onset blurring of vision in both eyes despite using glasses for about three days. Using of aripiprazole was observed in the patient's history. She was found to have myopia of -6.0 diopters in both eyes with measurement of otorefractometer; her visual acuity was 6/10 in both eyes with her glasses. The other eye examination findings of the patient were normal. The drug was discontinued, and the patient was followed. One mount later on examination, the patient's visual acuity increased to 10/10 in both eyes. Following the first day of the Alx values measured were 0.3 mm longer than one month after the measurement; the minimal difference between the other anterior segment findings were recorded. Although the specific mechanisms that cause acute myopia has not been fully revealed, it can be ciliary spasm, ciliary bodies effusion, peripheral uveal effusion and effects of ocular serotonergic intraneural fibers. We believe that it would be important for clinicians. They should keep in mind these conditions when prescribing aripiprazole and need to inform patients about the side effects related to the eye.Öğe Cerebral MR Spectroscopy Evaluation of the Neuroprotective Effects of Lithium and Olanzapine in Bipolar Affective Disorder Patients(Universitatsverlag Ulm Gmbh, 2008) Cumurcu, Birgul Elbozan; Karlidag, Rifat; Sarac, Kaya; Unal, Suheyla; Ozcan, Cemal; Erkorkmaz, UnalAim: We used the NAA measurements obtained by cerebral magnetic resonance spectroscopy to evaluate the neuroprotective effects of lithium and olanzapine in bipolar affective disorder patients in remissions. Methods:Ten bipolar affective disorder patients on lithium treatment for the last six years and who had not experienced a manic or depressive attack for the last three years and were followed up at the psychiatry outpatients department were included in the study. The patients were evaluated while on lithium, 14 days after lithium was stopped and at the end of the 411 week following olanzapine initiation, for a total of three times. Each evaluation consisted of a psychiatric interview, the Hamilton Depression Rating Scale (HDRS) and the Bech-Rafaelson Mania Scale (BRMS) in addition to MR spectroscopy imaging. Results: The cases were compared with a control group consisting of 10 age- and sex-matched healthy subjects. We measured the N-acetyl aspartate (NAA) peak quantitatively in the right dorsolateral prefrontal cortex (DLPF) and left hippocampus areas on MR spectroscopy and checked the ratio to the creatine (Cr) peak. The values from all three imaging studies were compared with each other and with the control subjects. Conclusions: There was no statistically significant difference between the NAA/Cr ratios of the patients receiving lithium, those not on medications or those receiving olanzapine and the healthy subjects. We did not observe any change in cerebral NAA levels following lithium and olanzapine treatment in bipolar affective disorder patients in remission.Öğe The Changes in Tear Film Parameters and Impression Cytology in Heavily Drinking Men(Lippincott Williams & Wilkins, 2013) Cumurcu, Tongabay; Gunduz, Abuzer; Cumurcu, Birgul Elbozan; Gul, Isil Gogcegoz; Akpolat, Nusret; Karlidag, RifatPurpose: To evaluate the tear film function and ocular surface changes in heavily drinking men. Methods: This prospective case-control study involved 35 male subjects with heavy alcohol consumption (group 1) and 35 age-and sex-matched control subjects (group 2). Best-corrected visual acuity measurement, slit-lamp examination, Schirmer I test, tear film break-up time (BUT) measurement, and conjunctival impression cytology were performed in all subjects. The results were compared between the 2 groups. Results: The mean Schirmer I test results in group 1 and group 2 were 8.31 +/- 3.56 mm and 13.17 +/- 5.71 mm, respectively, and the mean BUT values were 9.22 +/- 3.10 seconds and 13.20 +/- 4.04 seconds, respectively. The mean Schirmer I and BUT results were statistically lower in group 1 than in group 2 (P < 0.0001). The mean impression cytology scores in group 1 and group 2 were 2.08 +/- 0.78 and 1.37 +/- 0.94, respectively. A statistically significant difference was noted between the study and control groups for the grading of cytological changes (P = 0.001). Conclusions: Our data showed that heavily drinking men have decreased tear production, tear film instability, and significant degeneration of the ocular surface epithelium when compared with normal subjects.Öğe Çocuklar için Dijital Bağımlılık Ölçeğinin Türkçeye Uyarlanması: Güvenirlik ve Geçerlilik Analizi(2023) Kaçmaz, Cihangir; Cumurcu, Birgul Elbozan; Çelik, Osman TayyarAmaç: Bu araştırmanın amacı Çocuklar için Dijital Bağımlılık Ölçeğinin Türkçe’ye uyarlanmasını, psikometrik analizlerle güvenirlik ve geçerlik çalışmasının yapılmasıdır. Yöntem: Araştırma, uygun örnekleme yöntemi kullanılarak 165’i kız, 161’i erkek olmak üzere 326 ortaokul öğrencisiyle gerçekleştirilmiştir. Dil geçerliği çalışmasından sonra doğrulayıcı faktör analizi ile ölçeğin yapısı incelenmiş, benzer ölçek geçerliği ve madde ayırt edicilik gücü test edilmiştir. Ayrıca Cronbach Alfa güvenirlik katsayısı hesaplanmıştır. Bulgular: Analizler sonucunda kişiler arası ilişkiler ve içe dönük faktörler olmak üzere ölçeğin iki faktörlü yapısı doğrulanmıştır. %27’lik alt ve üst guruplar için madde ayırt edicilik gücünün ve madde toplam test korelasyonlarının yüksek olduğu, benzer ölçek geçerliği kapsamında uygulanana “Dijital Oyun Bağımlılığı” ölçeği puanları ile korelasyonun yüksek olduğu tespit edilmiştir. Son olarak Cronbach Alfa güvenirlik katsayısı kişiler arası ilişkiler için ,84 içe dönük faktörler için ,85 ve ölçeğin geneli için ,90 olarak hesaplanmıştır. Sonuç: Çocuklar için Dijital Bağımlılık Ölçeğinin Türkiye’de ortaokul öğrencilerinin dijital bağımlılıklarını ölçmek amacıyla geçerli ve güvenilir bir ölçektir.Öğe The Effect of Agoraphobia on Oxidative Stress in Panic Disorder(Korean Neuropsychiatric Assoc, 2013) Gul, Lsil Gogcegoz; Karlidag, Rifat; Cumurcu, Birgul Elbozan; Turkoz, Yusuf; Kartalci, Sukru; Ozcan, A. Cemal; Erdemli, M. ErmanWe aimed to investigate whether agoraphobia (A) in panic disorder (PD) has any effects on oxidative and anti-oxidative parameters. We measured total antioxidant capacity (TAG), paraoxonase (PUN), arylesterase (ARE) antioxidant and malondialdehyde (MDA) oxidant levels using blood samples from a total of 31 PD patients with A, 22 PD patients without A and 53 control group subjects. There was a significant difference between the TAG, PUN, ARE and MDA levels of the three groups consisting of PD with A, PD without A and the control group. The two-way comparison to clarify the group creating the difference showed that the TAG, PUN, and ARE antioxidants were significantly lower in the PD with A group compared to the control group while the MDA oxidant was significantly higher. There was no significant difference between the PD without A and control groups for TAG, PUN, ARE and MDA levels. We clearly demonstrated that the oxidative stress and damage to the anti-oxidative mechanism are significantly higher in the PD group with A. These findings suggest that oxidative/anti-oxidative mechanisms may play a more important role on the pathogenesis of PB with A.Öğe The Effect of Chronic Alcoholism on the Conjunctival Flora(Taylor & Francis Inc, 2016) Gunduz, Goksel; Gunduz, Abuzer; Polat, Nihat; Cumurcu, Birgul Elbozan; Yakupogullari, YusufAim: We aimed to investigate the effect of alcohol abuse on the conjunctival flora.Materials and methods: The cases were evaluated as two groups. The study group consisted of 55 heavy-drinking males diagnosed with alcohol abuse, while the control group consisted of 55 males without a history of alcohol abuse. Samples were taken from the inferior fornix conjunctiva with sterile cotton-tipped swabs (Amies transport medium) for culture. The samples were inoculated into blood agar, chocolate agar, eosine methylene blue agar and Saboraud-Dextrose agar (Oxoid/UK) with the dilution method.Results: The microorganisms that grew in study group subjects were Coagulase Negative Staphylococcus (CNS) in 30 (54.5%), Staphylococcus aureus in 14 (25.5%), Moraxella spp. in 3 (5.5%), Streptococcus spp. in 3 (5.5), Bacillus spp. in 3 (5.5%), Corynebacterium spp. in 3 (5.5%), Candida spp. in 3 (5.5%), Haemophilus spp. in 2 (3.6%), Acinetobacter spp. in 2 (3.6%), Neisseria spp. in 1 (1.8%) and Micrococcus spp. in 1 (1.8%). The results for control group were CNS in 31 (56.4%), Bacillus spp. in 7 (12.7%), S. aureus in 5 (9.1%), and Corynebacterium spp. in 2 (3.6%). Moraxella spp., Streptococcus spp., Candida spp., Haemophilus spp., Acinetobacter spp., Neisseria spp. and Micrococcus spp. microorganisms grew in the conjunctival flora samples of the study group but not in the control group. S. aureus colonization was significantly higher in the study group than the control group (p<0.05).Conclusion: The S. aureus colonization rate was statistically significantly higher in the study group. Some microorganisms only grew in the conjunctival flora samples of the study group. These findings indicate that the conjunctival flora in persons with chronic alcoholism is different than the normal population.Öğe GHRELIN AND LIPID LEVELS IN PANIC DISORDER BEFORE AND AFTER TREATMENT AND THEIR RELATIONSHIP WITH AGORAPHOBIA(Medicinska Naklada, 2015) Gul, Isil Gogcegoz; Cumurcu, Birgul Elbozan; Karlidag, Rifat; Turkoz, YusufBackground: We aimed to evaluate serum ghrelin (GHR) levels and lipid profile in panic disorder (PD), with and without agoraphobia, and to compare these parameters before and after treatment. Subjects and methods: The GHR and lipid profiles were measured in blood samples taken from 31 PD patients with agoraphobia, 22 PD patients without agoraphobia, and 53 control group subjects. 23 of the 53 patients who were prescribed 20 to 40 mg/day paroxetine had continued treatment. The 23 patients who had continued treatment were measured again at the end of twelve weeks. Results: The GHR and triglyceride (TRG), total cholesterol (Total-C), low-density lipoproteins (LDL-C), and very low-density lipoproteins (VLDL-C) levels were higher in the PD with agoraphobia group than the PD without agoraphobia and control groups. The 23 patients that had continued their treatment were re-evaluated, and the serum GHR, Total-C levels, and BMI after treatment were significantly decreased, compared to the values before treatment. Conclusions: There may be a pathophysiological relationship between the GHR and lipid profiles that interact with each other in PD. In fact, this relationship was more marked in PD with agoraphobia than in PD without agoraphobia.Öğe Influence of ABCB1 polymorphisms and serum concentrations on venlafaxine response in patients with major depressive disorder(Taylor & Francis Ltd, 2017) Ozbey, Gul; Celikel, Feryal Cam; Cumurcu, Birgul Elbozan; Kan, Derya; Yucel, Berna; Hasbek, Ekrem; Percin, FerdaBackground: The pharmacokinetics and the pharmacodynamics of antidepressants show large inter-individual variations which result in unpredictable clinical responses.Aim: The aim of the study was to examine the effect of ABCB1 polymorphisms and the serum concentrations on the efficacy and tolerability of venlafaxine in patients with major depressive disorder (MDD).Methods: Fifty-two outpatients who met the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) criteria for MDD were recruited for the study. The severity of depression was assessed using the 17-item Hamilton Rating Scale for Depression scale (HDRS17) and tolerability was assessed based on a query regarding side-effects for 6 weeks. The ABCB1 C3435T/A and G2677T/A polymorphisms were genotyped by PCR/RFLP and steady-state serum venlafaxine concentrations were measured by high-performance liquid chromatography.Results: Patients with the TT genotype for the C3435T and the TT/TA genotype for the G2677T/A polymorphism showed significantly higher frequencies in venlafaxine-induced akathisia. This relationship was not observed for efficacy. As regards serum venlafaxine concentrations, patient groups showed no significant differences in efficacy and tolerability.Conclusion: The results suggest that individuals with the TT-TT/TA genotypes for the C3435T-G2677T/A polymorphisms of ABCB1 may be pre-disposed to a risk of akathisia.Öğe An Investgation About the Relationship Between Vasopressin and Oxytocin in Persistent Type Functional Neurological Symptom Disorder(Korean Neuropsychiatric Assoc, 2021) Ornek, Bahar Yesil; Cumurcu, Birgul Elbozan; Zayman, Esra PorgaliObjective Functional neurogical symptom disorder (FNSD) is a somatic symptom disorder with loss of voluntary motor or sensory functions, which cannot be explained by another medical condition. The study aimed to examine the relationship of vasopressin and oxytocin in persistent type FNSD. Methods This study included 27 female patients between the ages of 20-57 who were diagnosed with FNSD according to DSM-5 and 27 healthy controls matched in terms of age and gender. Serum vasopressin and oxytocin levels were measured twice on the same day in fasting blood samples and the results were compared statistically. Results Vasopressin were lower in patients compared to controls while there was no difference between oxytocin levels. Childhood traumas were more common in patient group, and mean oxytocin level was lower in patients who exposed to childhood trauma, compared to controls. No significant difference was found between the groups in terms of vasopressin. Conclusion Changes in vasopressin and oxytocin balance in the pathogenesis of persistant FNSD, may likely to lead to physiological and behavioral consequences. Lower oxytocin levels may also be a marker of exposure to childhood trauma in FNSD. These neuropeptides plays important role in neuroendocrine balance of emotional behavior. Psychiatry Investig 2021;18(10):1018-1024Öğe Is There Any Relation Between Pseudoexfoliation Syndrome and Alzheimer's Type Dementia?(Taylor & Francis Inc, 2013) Cumurcu, Tongabay; Dorak, Ferhat; Cumurcu, Birgul Elbozan; Erbay, Lale Gonenir; Ozsoy, ErcanPurpose: To investigate the frequency of Alzheimer-related dementia in patients with pseudoexfoliation syndrome (PEX). Methods: Sixty-seven patients with PEX and 67 age-, gender-, and educational-background-matched control subjects were compared for the presence of Alzheimer-related dementia according to DSM-IV-TR. The effects of cataract, glaucoma, additional ocular and systemic disease on the dementia incidence were also evaluated in patients with PEX and the control group. Results: The frequency of Alzheimer-related dementia was higher in patients with PEX (p = 0.0001). The frequency of dementia in patients who had cataract was higher than in patients without cataract (p = 0.003). There was also an association between additional ocular disease and dementia (p < 0.05). However, there was no association between systemic disease and dementia (p > 0.05). Furthermore, there was no difference for the frequency of dementia between patients who had glaucoma or not among patients with PEX (p = 0.953). Conclusion: The increased frequency of Alzheimer-related dementia in patients with PEX is important and a possible association between PEX and Alzheimer's disease could be present.Öğe Less Prevalent Alcohol Use Disorders Among Turkish Psychiatric Outpatients(Universitatsverlag Ulm Gmbh, 2009) Ozcan, Mehmet Erkan; Egri, Mucahit; Cumurcu, Birgul ElbozanAim: This study aimed to assess the frequency of problem drinking among outpatients who were seen at a general psychiatry outpatient clinic of a university hospital located in the province of Malatya, eastern Turkey. Methods: Five-hundred and seven patients between 17-72 years old were interviewed in a 6 months period. The mean age was 35.8 +/- 12.4 years, and 72.2% of the sample was female. Patients who were diagnosed with one of the following disorders were included: anxiety disorders (n=287), major depressive disorder (n=110), and somatoform disorders (n=110). Comorbidities with other DSM-IV Axis-1 disorders were excluded. Patients with other psychiatric disorders, such as schizophrenia and psychoses, bipolar disorders, primary alcohol and substance use disorders, and sexual function disorders were seen at separate, specialized outpatient clinics. Results: Overall, 19.8% of respondents reported alcohol use in the past year with significant differences in prevalence rates by gender; 41.7% among males and 11.5% among females (chi(2) =57.55, p<0.0001). The frequency of alcohol use (p=0.86), or family history of alcohol intake (p=0.22), or problem drinking (p=0.07) was not significantly different among patient groups. None of patients with somatoform disorders had problem drinking. Conclusion: Both alcohol use, and problem drinking frequencies were lower than the results of the studies from other countries. These results might be impaired, since the majority of patients was female. Problem drinking and subjects with a positive CAGE score were more common among males aged 40-54 years.Öğe The neuropsychological and neurophysiological profile of women with pseudoseizure(W B Saunders Co-Elsevier Inc, 2013) Almis, Behice Han; Cumurcu, Birgul Elbozan; Unal, Suheyla; Ozcan, A. Cemal; Aytas, OzgurObjective: Our aim in this study was to compare the assessments of neuropsychological tests and the p50 neurophysiological test of patients with seizure diagnosed as conversion disorder and healthy control subjects, and to investigate the neurological status in conversion disorder with pseudoseizure. Methods: A total of 22 female conversion disorder patients with convulsions diagnosed according to SCID-I/CV and 22 healthy women were included in the assessment. The participants were administered WMS-R, the cancellation test, and the Stroop test as neuropsychological tests and p50 was assessed as a neurophysiological test. Results: The patient's results for the neuropsychological tests were found to be significantly low compared to the control group. The p50 sensory gating ratios of the patient group were statistically significantly lower than the controls. There was no significant correlation between the neuropsychological test scores and gating ratios of the patient and control groups. Conclusions: This study is the first to check sensory gating in conversion disorder patients with pseudoseizure and its most important result is finding reduced p50 sensory gating in patients. Our results suggest that these patients have a neurological tendency to this disease due to functional neurophysiological features. (C) 2013 Elsevier Inc. All rights reserved.Öğe Normative data and factorial structure of the Turkish version of the Junior Temperament and Character Inventory-Revised(Taylor & Francis Ltd, 2017) Kose, Samet; Celikel, Feryal Cam; Akin, Ercan; Kaya, Cahit; Cumurcu, Birgul Elbozan; Etikan, Ilker; Cloninger, C. RobertObjective: Junior Temperament and Character Inventory (J-TCI) was developed by Luby, Svrakic, McCallum, Przybeck, and Cloninger based on Cloninger's biopsychosocial model to assess temperament and character dimensions in children and adolescents. Methods: The Turkish version of J-TCI-Revised (J-TCI-R) was administered to 1129 elementary and middle-school (male/female, 546/583) students. Internal consistency reliabilities were measured by Cronbach's alpha; test-retest was assessed across one month. Results: Cronbach's alphas for the subscales of J-TCI-R ranged from 0.60 to 0.75 for temperament and character subscales, which were comparable to US and other populations. The correlations between baseline and one month after administration of J-TCI-R were highly and statistically significant (r = 0.578-0.674 for scales and 0.366-0.582 for subscales) (n = 795). Factor analysis results using Eigenvalue greater than one rule indicated three out of four factors for temperament scales and one out of two factors for character subscales which were similar to findings from the other countries. When all of the subscales were subjected to factor analysis, four out of six factors were retained. To our knowledge, this is the first study analysing psychometric properties and factorial construct of the J-TCI-R. Conclusions: The internal reliability coefficients and test-retest indicated a good stability of scores over time and the factorial structure was consistent with Cloninger's model of personality. The reliability and validity of the Turkish version of the TCI is therefore supported.Öğe Plasma Iron, Copper, Zinc Levels in Patients Experiencing Delirium Following Coronary Artery Bypass Grafting(Universitatsverlag Ulm Gmbh, 2008) Cumurcu, Birgul Elbozan; Karlidag, Rifat; Unal, Suheyla; Sezer, Ozlem Hesna; Battaloglu, Bektas; Mendil, Durali; But, KadirAim: To investigate the role of plasma iron (Fe), copper (Cu), and zinc (Zn) levels on delirium in patients following coronary artery bypass grafting (CABG). Methods: Twelve of the 50 patients included in the study showed signs of delirium during postoperative follow-up. We diagnosed delirium using DSM-IV-TR (Diagnostic and Statistical Manual of Mental Disorders) criteria. Delirium Rating Scale (DRS) was used to estimate delirium severity. In both groups pre-and postoperative plasma Fe, Cu, and Zn levels were analyzed with atomic absorption spectrometry (FAAS) method and compared statistically. Results: There was no significant difference between the groups for preoperative plasma Fe and Zn levels, while the Cu level was statistically significantly lower in the delirium group (p<0.05). The postoperative plasma Fe and Zn levels were statistically significantly higher in the delirium group (p=0.0001). The Cu level was statistically significantly higher in the delirium and non-delirium group (p=0.0001, p<0.05, respectively). The comparison of postoperative plasma Fe, Cu and Zn levels between the two groups showed a statistically significantly higher level in the delirium group compared to the non-delirium group (p=0.0001). The postoperative plasma Cu/Zn levels were statistically significantly higher in the delirium group (p<0.05). Conclusion: It may be suggested that the increased postoperative plasma levels of these trace elements may play a role in delirium seen after CABG.Öğe Postoperative Cognitive Dysfunction in Living Liver Transplant Donors(Baskent Univ, 2014) Bucak, Nizamettin; Begec, Zekine; Erdil, Feray; Toprak, Huseyin Ilksen; Cumurcu, Birgul Elbozan; Demirtas, Yasemin; Yologlu, SaimObjectives: Postoperative cognitive dysfunction is a serious complication that may be associated with increased mortality. Living-donor liver transplant includes major surgery for the donor. The purpose of this study was to evaluate preoperative and postoperative cognitive function of liver donors in living-donor liver transplant. Materials and Methods: In 102 patients who had hepatectomy for liver transplant donation, preoperative and postoperative (1 week) neuropsychologic tests were performed including the Trail Making Test, the Stroop effect, score on the Beck Depression Inventory, and the mini-mental state examination. Results: Liver transplant donors had significantly lower mean Trail Making A Test duration and greater mean Trail Making B Test error number after than before surgery. The mean Stroop effect reading durations (black and white reading; reading colored words) were significantly greater after than before surgery; the mean time difference between naming the colors of colored words minus reading colored words, and the error number, were smaller after than before surgery. The mean score on the Beck Depression Inventory and mini-mental state examination score were similar before and after surgery. Conclusions: Mild frontal lobe dysfunction may be present in liver donors at 1 week after surgery, and postoperative attention problems may be experienced by these patients.Öğe Psychotic Disorder Releated with Graves Disease: A Case Report(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2012) Gul, Isil Gogcegoz; Kartalci, Sukru; Karlidag, Rifat; Cumurcu, Birgul ElbozanAlthough the association between disorders of thyroid function and psychiatric symptomatology is well established, psychoses associated with hyperthyroidism are uncommon. Behavioral abnormalities that may extend to psychosis can be a manifestation of severe hyperthyroidism due to Graves' disease. In this case report, we present a 39-year-old man who developed a psychotic disorder due to Graves' disease. (Archives of Neuropsychiatry 2012; 49: 317-319)Öğe Rabbit syndrome: Developed after increasing the dosage of quetiapine in a patient using quetiapine with duloxetine(Kure Iletisim Grubu A S, 2011) Cumurcu, Birgul Elbozan; Almis, Behice Han; Kartalci, Sukru; Karlidag, RifatRabbit syndrome: Developed after increasing the dosage of quetiapine in a patient using quetiapine with duloxetine Fifty-six years old, female patient who was being followed and treated for resistant depression, had been using duloxetine 60 mg/day and quetiapine 300 mg/day for 3 months. After 2 weeks the quetiapine dose was increased to 600 mg/day because of resistant depression concomitant with insomnia. A movement disorder was observed, appearing as a rhythmic tremor in the perioral muscles which was defined by the patient as involuntary. This involuntary rhythmic perioral tremor was diagnosed as rabbit syndrome and for this reason quetiapine, the only antipsychotic used by the patient, was gradually decrease in dose and eventually stopped. Four weeks after stopping the quetiapine, the patient's involuntary perioral rhythmic movements decreased from four to zero points, according to the lips and perioral subgroup of the Abnormal Involuntary Movements Scale (AIMS).Öğe Recurrent priapism during quetiapine treatment(Kure Iletisim Grubu A S, 2010) Kartalci, Sukru; Gul, Isil Gogcegoz; Karlidag, Rifat; Cumurcu, Birgul ElbozanPriapism is defined as prolonged penile erection without sexual desire or stimulation. Since it is a urological emergency, serious consequences can occur if neglected. Different etiological factors including hemotopoetic disorders, malignancies, various drugs, perineal trauma, etc. can cause priapism. Drug induced priapism can occur during treatment with antispychotic medications. This report discusses a case of priapism, which occurred when the dose of quetiapine was increased.Öğe Refraction and eye anterior segment parameters in schizophrenic patients(Consel Brasil Oftalmologia, 2015) Cumurcu, Tongabay; Keser, Sinem; Cumurcu, Birgul Elbozan; Gunduz, Abuzer; Kartalci, SukriPurpose: To evaluate the difference in terms of refractive errors and anterior segment parameters between schizophrenic patients and healthy volunteers. Methods: This study compared 70 patients (48 men) who were diagnosed with schizophrenia with a control group of 60 (35 men) who were similar in terms of age, gender, education, and socioeconomic level. Anterior segment examination was performed using a Scheimflug system. Axial length and lens thickness (LT) were measured using optic biometry. The following tests were administered to the psychiatric patient group: Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Negative Symptoms (SANS), and Scale for the Assessment of Positive Symptoms (SAPS). Results: Mild myopia was detected in both the schizophrenic and control groups, with no statistically significant difference (p>0.005). Corneal volume (CV), anterior chamber volume (ACV), anterior chamber depth (ACD), and central corneal thickness (CCT) values were lower in the schizophrenic group, and there was a statistically significant between-group difference (p=0.026, p=0.014, p=0.048, and p=0.005, respectively). LT was greater in schizophrenics, and the difference was found to be statistically significant (p=0.006). A statistically significant negative correlation was found between SAPS and cylinder values (p=0.008). The axial eye length, cylinder value, pupil diameter, mean keratometric value, and anterior chamber angle revealed no statistically significant difference between the groups (p>0.05). Conclusion: No statistically significant difference was detected in terms of refraction disorders between schizophrenics and the healthy control group, while some differences in anterior chamber parameters were present. These results demonstrate that schizophrenics may exhibit clinical and structural differences in the eye.
