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    Effect of troponin I and coagulation parameters on mortality in COVID-19 patients
    (Marmara Univ, Fac Medicine, 2023) Dag, Meral; Bulut, Nilufer; Taskapan, M. Cagatay
    Objective: Our aim is to determine the levels of troponin-I and some coagulation markers (D-dimer, fibrinogen and International Normalized Ratio (INR)) in coronavirus disease 2019 (COVID-19) patients and to investigate the effects of these markers on mortality.Patients and Method: It is planned as a descriptive, cross-sectional and analytical study. The study was conducted by retrospectively scanning the files of COVID-19 patients who applied to Inonu University Turgut Ozal Medical Center between 01.03.2020 and 31.12.2020. Levels of cardiac troponin I markers and coagulation parameters (D-dimer, fibrinogen and INR) were detected.Results: The results of a total of 1858 patients were obtained. One thousand, three hundred and twenty-six patients with only troponin I and D-dimer results (Group 1), 606 patients with only troponin I and fibrinogen results (Group 2), and 1308 patients with only troponin I and INR results (Group 3) were included. Troponin I levels were significantly higher in all patients who died. 96.6% of the patients with high D-dimer levels died in Group 1, 85.5% of the patients with high fibrinogen levels died in Group 2 and 77.3 % of the patients with high INR levels died in Group 3.Conclusion: Measurements of troponin-I and coagulation markers such as D-dimer, fibrinogen and INR can help predict clinical severity and mortality in COVID-19 patients.
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    The Morphological and Numeral Changes of Goblet Cells in the Jejunum of Ischemia-Reperfusion Applied Rats
    (Ortadogu Ad Pres & Publ Co, 2010) Dag, Meral; Kurus, Meltem; Sogutlu, Gokhan; Estegoglu, Mukaddes; Ozturk, Feral; Yologlu, Saim; Otlu, Ali
    Objective: In this study, we aimed to investigate the numeric and morphological changes of goblet cells after experimental ischemia and reperfusion damage. Material and Methods: In our study, male Sprague Dawley rats were randomly divided into four groups being eight rats in each group. Groups were: control, sham, ischemia (15 minutes) and ischemia-reperfusion groups (I/R, 15 min. I/15 min.R). After the experiment, all rats were sacrificed and their jejunums were taken out. All the necessary procedures were carried out for morphological evaluation. Results: In the ischemia group, villi morphological changes from splitting up to atrophy, and were shorter; goblet cells were found to show reduction both in number and size. On the other hand, it was found that goblet cells in the crypts showed no change in number but in size. Findings in the I/R group were milder than the ischemia group, but the sizes of villi were found smaller in this group. While the number of goblet cells in the villi was normal, it was decreased in the crypts and the sizes of goblets both in the villi and in the crypts were reduced. Conclusion: We thought that during the ischemia, the number of goblets were decreased since they fall into the lumen. The rest were small because they came from the basis of the crypts; during the I/R procedure, the number of cells turned to normal because of the arrival of the goblets from the crypts to the villi. However, in this way the number in them in the crypts decreased and they looked small due to incomplete maturation.