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    The Effect of Dust-Mites on Nitric Oxide Production
    (Tubitak Scientific & Technological Research Council Turkey, 2009) Yazar, Sueleyman; Kilic, Eser; Atambay, Metin; Karabulut, Aysun Bay; Aycan, Oezlem Makbule; Tamer, Guelden Soenmez; Daldal, Nilguen
    Aim: We aimed to investigate the effect of house dust mite on the level of nitric oxide in patients who had dust mite in their houses and suffering from rhinitis and/or asthma and/or eczema-like allergic symptoms and were positive for skin tests (Prick). Materials and Methods: The effect of dust-mites on nitric oxide concentration was investigated using Griess method in patients who had allergic symptoms and were positive for skin tests. Results: The plasma nitric oxide level was found to be statistically higher in patients who had dust mite in their houses and suffering from allergic symptoms and were positive for skin tests than in patients who did not have dust mite in their houses but were positive for skin tests or negative for skin tests. In addition. there was no statistical difference in the level of nitric oxide between the patients who did not have dust mite in their houses but were positive for skin tests and the patients who did not have dust mite in their houses and were negative for skin tests. Conclusions: There seems to be an effect of house dust mite on the level of nitric oxide. However, the molecular mechanism underneath of this effect is not yet clear. A plausible explanation for this might be the intrinsic radical properties of nitric oxide and its protective effect against the parasitic agents.
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    The Epidemiology of Microsporidias in Humans (Malatya sample)
    (Tubitak Scientific & Technological Research Council Turkey, 2009) Karaman, Uelkue; Daldal, Nilguen; Atambay, Metin; Colak, Cemil
    Aim: Microsporidias, first isolated and defined in 1857, are obligate intracellular parasites observed in animal groups and especially invertebrates. Generally homosexual patients and patients who are HIV positive and immune suppressed constitute the participants of international studies about the epidemiology of microsporidias. No previous studies about the prevalence of the parasite in Turkey have been found in the literature. This study aimed to determine the epidemiology of microsporidias in and around Malatya. Materials and Methods: Feces samples (n: 2665) from patients who presented at inonu University Medical Faculty policlinics in 2006 with some digestive system complaints and were referred to the Parasitology Department were analyzed. The samples were analyzed using modified trichrome (MTS). Acid-Fast-Trichrome, Calcofluor, and Giemsa staining. Results: In all 226 samples (8.5%) were positive. There was a statistically significant relationship between lack of appetite, general body pruritus. immune suppression + cancer. dyspnea, and ulcerative colitis. Conclusions: It is important to check feces samples for Microsporidium spp. parasites regularly for cases including unexplained diarrhea, stomachache, lack of appetite, general pruritus, immune suppression + cancer, asthma, and ulcerative colitis, since Microsporidium spp. is not a commonly known parasite in Turkey.
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    MALONDIALDEHYDE, GLUTATHIONE AND NITRIC OXIDE LEVELS IN PATIENTS WITH ENTEROBIUS VERMICULARIS INFECTION
    (Ankara Microbiology Soc, 2010) Kiran, Tugba Raika; Karaman, Uelkue; Colak, Cemil; Karabulut, Aysun Bay; Daldal, Nilguen
    The aim of this study was to investigate the levels of malondialdehyde (MDA) and nitric oxide (NO) which are indicators of oxidative stress and also the level of glutathione (GSH) which is an antioxiclant molecule, in patients with Enterobius vermicularis infection. A total of 41 patients (mean age: 36.4 years; 31 were male) and 40 healthy controls (mean age: 40.2 years; 28 were male) were included to the study. None of the patients and controls have had history of hormone/steroid drug use, smoking and alcoholism. The mean level of GSH in patient and control groups were found 1.17 +/- 0.02 mu mol/l and 2.49 +/- 0.10 mu mol/l; MDA 26.97 +/- 2.06 mu mol/l and 19.47 +/- 2.25 mu mol/l; NO 20.74 +/- 0.60 pmol/dl and 17.83 O.SO pmol/dI, respectively. The mean GSH level in patient group was statistically significantly lower (p< 0.05) than controls, while the mean MDA and NO levels were statistically significantly higher (p< 0.05). These results indicated that the consumption of GSH was increased due to the severity of oxidative stress in patients infected with E.vermicularis. Detailed experimental and clinical studies are required to enlighten the relation of GSH in the pathogenesis of E.vermicularis infection. Since oxidative stress is increased during enterobiosis, the use of antioxiclant agents (e.g. vitamins C and E) for the supportive treatment deserves evaluation.