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Öğe A case of alveolar echinococcosis in Malatya province(2008) Atambay M.; Karaman U.; Miman O.; Karada? N.; Sö?ütlü G.; Daldal N.The disease resulting from being infected with the larval stage of Echinococcus multilocularis is called alveolar echinococcosis (AE). In our country AE is seen in eastern and southeastern regions of Anatolia. Previously no case of AE had been reported by any hospital in Malatya. In this one case, a 70 year-old woman who presented at the Inönü University Turgut Ozal Medical Center with a right upper quadrant abdominal pain was given a diagnosis of cystic echinococcosis (CE) by dynamic liver computed tomography. The pathological examination following the cystectomy revealed the presence of AE. This is a report of the first AE case detected in Malatya province.Öğe The frequency of intestinal parasites and head lice among students of the Akşemsettin Primary School for Deaf Students(2007) Atambay M.; Karaman O.; Karaman U.; Aycan O.; Yolo?lu S.; Daldal N.Parasitic infections especially affect those children in critical phases of growing and development. They can lead to malnutrition, malabsorption, mental and social adaptation problems, and critical illnesses that hinder productivity. This is an important health problem in Turkey, and intestinal parasites are quite frequently found in boarding school and care centers for children. The aim of this study was to discover and treat the parasitological agents found in the students of the Primary School for Deaf Students. A total of 117 fecal specimens and material from the perianal region (using the cellophane tape method) were collected from deaf students and examined during 2003-2004 school season. Also the students were scanned for adult head lice and their eggs. As a result, 53 (45.3%) children with intestinal parasites and 6 (5.1%) with head lice were detected in the study. The patients were treated and informed about means of protection. The same children were examined again after six months: Only 24 (20.5%) children had intestinal parasites and 2 (1.7%), head lice. Thus, the decrease in parasitic infections was found to be significant (qui-square test in dependent samples P < 0.05). Therefore it was concluded that the schools should be scanned for intestinal parasites and head lice, and both treatment and training in the subject should be given the necessary importance.Öğe Frequency of the appearance of Demodex sp. in various patient and age groups(2007) Aycan O.M.; Otlu G.H.; Karaman U.; Daldal N.; Atambay M.Demodex folliculorum and Demodex brevis are acari that can be found in hair follicles and sebaceous glands of the skin, especially on face of humans. In this study, Demodex sp was investigated in regard to allergic diseases, age and gender. A total of 197 patients (117 with rosacea, 29 with akne vulgaris, and 51 with allergic diseases) were examined using the standardized skin surface biopsy (SSSB) and 97 out of 197 (49.23%) cases were found to be positive by the Inonu University Medical Faculty Department of Parasitology. There was no significant difference between mite positivity and negativity between the genders, while a higher rate of Demodex sp. was found in patients with rosacea and a lower rate in patients under 20 years old (p0,005). As a result, patients over 20 years old, especially those with rosacea, must be investigated for Demodex sp.Öğe [Histopathology of strobilocercosis found in the livers of white mouse.].(2010) Aydin N.E.; Miman O.; Gül M.; Daldal N.The adult form of Taenia taeniaeformis is found in the intestine of the cat and cheetah. The larva form is called Strobilocercus fasciolaris and is found in rodents such as mice and rats. Our objective was to draw attention to that rare zoonosis, since it has already been reported in the literature as strobilocercosis in humans. During an experimental animal study conducted at Inonu University, some unexpected cystic formations were found in the livers of nine 6-8-month-old healthy white mice, which affected the conducted study negatively. These cystic formations were examined histopathologically. Prepared sections were stained with haemotoxylin eosin, periodic acid-Schiff and Masson trichrome stains, and examined by light microscopy. Strobilocercus fasciolaris larvae that curled towards cyst cavity and their hooks were seen. Plasma cells, macrophage, focus of eosinophilic infiltration and fibroblastic connective tissue were simultaneous found. In this paper, histopathological changes in intermediate hosts caused by Strobilocercus fasciolaris and other cestod larvae have been discussed.Öğe House dust mite fauna in Malatya(2006) Atambay M.; Aycan O.M.; Daldal N.The organisms in the Acarina order of the Arachnida class that form an important group of the Arthropoda are called mites. Dermatophagoides pteronyssinus (Trouessart, 1897) and D. farinae (Hughes, 1961) are known to be the most common mites found in house dust. The aim of this study was to determine the house dust mite fauna in Malatya that had not been investigated previously. In this study, a total of 303 house dust samples collected from various districts of Malatya between June 1, 2000 and November 20, 2001 were examined. The dust samples were examined by the lactic acid precipitation method which was modified from the Spieksma-Boezaman's method. The rate of mites was found to be 23.1%. In conclusion, the rate of mites detected in this study was considered to be high considering the altitude and humidity of Malatya.Öğe House dust-mites: Effect on antioxidant enzyme activities(2006) Karabulut A.B.; Atambay M.; Karaman U.; Kilic E.; Yazar S.; Saraymen R.; Daldal N.Background: House dust-mites are potent allergens of the indoor environment and are common inhabitants of houses worldwide. Free radicals are constantly produced by cells, mostly as reactive oxygen species. Once produced, free radicals are removed by antioxidant defenses, including the enzymes SOD, GPx, and CAT. Material/Methods: The aim was to describe the importance of the antioxidant enzymes SOD, GPx, and CAT co-acting in human cells against toxic reactive oxygen species and their relationship with pathophysiological processes in subjects who have dust-mites in their homes. Results: The activities of erythrocyte GPx and SOD in skin-test-positive (dust-mite-positive/negative) patients were significantly lower than those in dust-mite- and skin-test-negative controls (p<0.05). Among the skin-test-positive patients, SOD activity was found to be lower in dust-mite-positive than in dust-mite-negative patients (p<0.05). There was not a statistically significant difference between the CAT levels of skin-test-positive (dust-mite-positive/negative) patients and dust-mite- and skin-test-negative controls (p>0.05). Conclusions: This study clearly shows that dust-mite depresses the activities of SOD, GPx, and, to a small extent, CAT, which influence cellular reducing capacity and consequently may increase asthma risk more than other allergens. © Med Sci Monit, 2006.Öğe Incidence of cryptosporidium spp. in the human population of Malatya in Turkey(Acta Medica Mediterranea, 2015) Karaman Ü.; Daldal N.; Özer A.; Engiyurt Ö.; Ertürk Ö.Aims: Cryptosporidium species, settled in the microvilli of digestive and respiratory systems of vertebrates, infect mammals, poultry, fish and reptiles. Cryptosporidium species are common worldwide. Symptoms vary depending on species of infected host, condition of the immune system and age. In healthy patients with strong immune system it is characterized by self-limiting diarrhea in approximately 2 weeks, whereas in people with suppressed immune systems it can cause diarrhea such as cholera and could create a life-threatening clinical condition The aim of this study is to determine the epidemiology of Cryptosporidium species in the human population of Malatya province and around. Materials and methods: In Malatya province in 2006, 2.281 stool samples were taken from patients admitted to the Inonu University Faculty of Medicine Parasitology Department with the gastrointestinal complaints and analyzed. On the other hand a questionnaire has been prepared to determine the epidemiology of Cryptosporidium species in the human population of Malatya province. Each patient included in the study filled out and signed a patient information form. Results: In the studies, it has been reported that the Cryptosporidium infection rate is 6.1% in the developing countries and it is 2.1% in the developed countries. In different studies carried out in Turkey, it has been reported that the prevalence of infection is between 0-35.5%. Stool samples were examined by direct microscopy and acid-fast staining method and 161 (7.1%) of them were positive. In this study, a significant relationship hasn't been found in patients with loss of appetite, general body itching, allergies, immunosuppressive and cancer, dyspnea, ulcerative colitis, diarrhea, abdominal pain, salivation, constipation, nausea, vomiting, growth retardation, the rectal itching and anemia, but in the statistical analysis, the difference is statistically significant. Conclusion: Consequently, molecular studies are needed to determine the common Cryptosporidium species and their sources in Malatya province and around. This will guide in determining strategies of public health education.Öğe Incidence of intestinal parasites among primary school children in Malatya(2006) Celik T.; Daldal N.; Karaman U.; Aycan O.M.; Atambay M.The aim of this study was to determine the incidence of intestinal parasites among primary school children in the central region of Malatya and to educate the children about parasitic diseases. During the study, cellophane tape preparations and stool samples that had been prepared using direct mounting methods were examined. In addition the students were informed about intestinal parasites. Parasitic infection was observed in 415 (22.5%) out of 1838 students and the highest rate of 10.6% was that of Enterobius vermicularis. The rates of Giardia intestinalis, Entamoeba coli, Blastocystis hominis, Taenia sp., Hymenolepis nana, Trichomonas hominis, Ascaris lumbricoides and Iodamoeba butschlii were found to be 8.5%, 1.9%, 1.4%, 0.3%, 0.1%, 0.1%, 0.05%, and 0.05%, respectively. Thus, intestinal parasites are important among primary school children in Malatya and it seems that there is a relationship between socioeconomic conditions and the rate of intestinal parasites.Öğe Incidence of intestinal parasites in municipal sanitary workers in Malatya(2006) Karaman U.; Atambay M.; Aycan O.; Yolo?lu S.; Daldal N.The incidence of intestinal parasites is closely related to such factors as the socio-economic level of the society, nutritional and hygienic habits, climate, environmental conditions, infrastructure and degree of literacy. In this study, the municipal sanitary workers who are regarded as a high risk group in Malatya were examined for intestinal parasites. Cellophane slides and fecal samples from 241 workers were examined and intestinal parasites were found in 93 (39.0%). The most common parasite was Entamoeba coli (34). Other parasites detected include Enterobius vermicularis (32), Giardia intestinalis (22), Blastocystis hominis (8), Iodamoeba butschlii (5), Entamoeba histolytica (2), Taenia sp. (2), Chilomastix mesnili (2), Dientamoeba fragilis (2), Entamoeba hartmanni (1), Trichomonas intestinalis (1) Hymenolepis nana (1), and Ascaris lumbricoides (1). A training seminary was conducted in order to inform all the workers about means of protection. The workers were given suitable treatment and were called for control after a month. The examinations revealed a significant decrease in the incidence rate of parasites (qui-square test in dependent samples P<0.05). It was concluded that offering training seminaries for certain occupational groups under risk is efficient in terms of protection.Öğe Investigation of the prevalence of Trichomonas vaginalis with respect to diverse social variables in women (Malatya, Turkey)(2006) Karaman U.; Atambay M.; Yazar S.; Daldal N.Trichomonas vaginalis is a monoxen parasite and its definitive host is human. It is known that the way of life is an important factor affecting incidence because of sexual transmission. In the present study, the incidence of T. vaginalis has been investigated with direct microscopy, Giemsa staining and culture (cysteine-peptone-liver-maltose (CPLM)). The study included 675 females with complaints of vaginal discharge who presented at different health departments or hospitals in the Malatya region during 2000-2001. T. vaginalis was seen in 55 (8.1%) patients. In addition, during period of presentation, a questionnaire was used to determine the relationship between the sociocultural status of the women and the incidence of T. vaginalis. Some of the questions in this questionnaire showed statistically significant differences in T. vaginalis infections related to the women's sociocultural status. These are as follows: type of toilet used; method and frequency of bathing; type, color, odor and frequency of vaginal discharge, level of knowledge of common sexually transmitted diseases and trichomoniasis; employment or non-employment of herself and her husband; life style in home; and educational level of husband. However, there was no statistical difference seen between other questions in the questionnaire and the existence of T. vaginalis infection.Öğe Malaria cases detected by active surveillance in Malatya(2006) Atambay M.; Karaman U.; Yaşar S.; Aycan O.M.; Daldal N.Malaria continues to be an important health problem in and around Malatya. Although the disease can be kept under control thanks to the regular work of the Centre for the Struggle against Malaria, it can not be eradicated fully due to the socio-economic conditions in the region. The aim of this study was to determine the prevalence of the disease through active surveillance in those regions where it is most common. From 2003, until 2004, 8856 blood samples were collected at one month intervals and 66 patients were found to be positive. Sixty three of the patients were Plasmodium vivax positive and 3 patients, P. falciparum, positive. The questionnaire administered to the positive patients (ranging from 02-70 years of age) revealed that 8 of the cases originated from extra-provincial sources. Men constitute 43% of all patients and women, 23%. Consequently it was concluded in this study that malaria threatens the people in the region. Therefore it was considered important for the Malatya Centre for the Struggle against Malaria and the local university to cooperate in the struggle against malaria by offering planned training programs in public health.Öğe Malaria cases in Malatya during the past seven years(2007) Karaman U.; Atambay M.; Yaşar S.; Colak C.; Miman O.; Daldal N.Malaria can be seen in every region inhabited by human blood-sucking Anopheles and species of disease-causing Plasmodium. Since the region is on the crossroads of other cities where malaria is more widespread and it has a population of seasonal workers and an increasing number of tourists during the summer, additional imported cases may also be detected in the Malatya region. The aim of this study was to determine the state of malaria for the past seven years in Malatya. According to the records of the Malaria Control Unit of the Health Directorate of the Malatya province, 189 positive patients were reported during the seven years from 1999-2005. Of these cases, 186 (98.4%) were P. vivax, while 3 (1.6%) were imported cases of P. falciparum malaria. The rate of positivity was found to be 58.2% in male patients and 41.8% in female patients. Consequently, malaria can be said to persist as a health problem in Malatya region. It was concluded that people in the region should be informed about malaria and the ways to protect themselves.Öğe Malondialdehyde, glutathione and nitric oxide levels in patients with Enterobius vermicularis infection(2010) Kiran T.R.; Karaman Ü.; Çolak C.; Bay Karabulut A.; Daldal N.The aim of this study was to investigate the levels of malondialdehyde (MDA) and nitric oxide (NO) which are indicators of oxidative stress and also the level of glutathione (GSH) which is an antioxidant molecule, in patients with Enterobius vermicularis infection. A total of 41 patients (mean age: 36.4 years; 31 were male) and 40 healthy controls (mean age: 40.2 years; 28 were male) were included to the study. None of the patients and controls have had history of hormone/steroid drug use, smoking and alcoholism. The mean level of GSH in patient and control groups were found 1.17 ± 0.02 ?mol/l and 2.49 ± 0.10 ?mol/l; MDA 26.97 ± 2.06 ?mol/l and 19.47 ± 2.25 ?mol/l NO 20.74 ± 0.60 ?mol/dl and 17.83 ± 0.50 ?mol/dl, respectively. The mean GSH level in patient group was statistically significantly lower (p< 0.05) than controls, while the mean MDA and NO levels were statistically significantly higher (p< 0.05). These results indicated that the consumption of GSH was increased due to the severity of oxidative stress in patients infected with E.vermicularis. Detailed experimental and clinical studies are required to enlighten the relation of GSH in the pathogenesis of E.vermicularis infection. Since oxidative stress is increased during enterobiosis, the use of antioxidant agents (e.g. vitamins C and E) for the supportive treatment deserves evaluation.Öğe The prevalence of Microsporidium among adult patients admitted to the parasitology laboratory at the Inonu University Turgut Ozal Medical Center(2008) Atambay M.; Karaman U.; Daldal N.; Colak C.Microsporidium can cause acute and self-restricted diarrhea cases among immunocompetent patients. The aim of this study was to investigate the presence of intestinal parasites and Microsporidium in patients presenting at the internal diseases polyclinic with some digestive system complaints but no immune suppressive problems, and to detect whether it has anything to do with the complaints. A total of 781 fecal samples were investigated for intestinal parasites and Microsporidium. Intestinal parasites were found in 16.11% and Microsporidium in 6.5%. A significant correlation was observed between the presence of intestinal parasites other than Microsporidium and dyspepsia, while in the case of Microsporidium, a significant frequency of dyspepsia and fatigue was observed. It was found that the presence of Microsporidium does not differ by age and gender. From the findings, it was concluded that patients with digestive system complaints should be examined for Microsporidium in addition to intestinal parasites, and the symptoms of dyspepsia and a lack of appetite should especially be given more careful attention.Öğe The prevalence of Microsporidium among patients given a diagnosis of cancer(2008) Karaman U.; Atambay M.; Daldal N.; Colak C.The aim of this study was to determine the frequency of Microsporidium among patients given a diagnosis of cancer. For this purpose fecal samples from 320 patients aged 23.60+/-23.00 years were examined using native-Lugol and sedimentation methods and evaluated with modified trichrome, trichrome, and calcofluor dyes. Moreover a control group of 320 non-cancer patients was set up. While 10.9% of the patient group was found to have Microsporidium, only 5.6% of the control group did. Comparison between the control and patient groups in terms of presence of Microsporidium revealed a statistically significant difference. The analysis of a possible relation between intestinal parasites and the presence of Microsporidium revealed a statistically significant correlation between Microsporidium and Blastocystis hominis (P < 0.05). The frequencies of intestinal parasites in the control group and the patient group were found to be 17.8% and 18.1%, respectively. From the findings it was concluded that presence of intestinal parasites and Microsporidium in cancer patients can cause critical problems and adversely affect the therapy. Moreover it was suggested that cancer patients should be informed about regular feces examination and protection against parasites in order to improve their life standards and protect them against parasite infections during treatment.Öğe The relationship between the skin allergy test and house dust mites(2006) Atambay M.; Aycan O.M.; Yolo?lu S.; Karaman U.; Daldal N.Since 1960 it has been known that house dust mites are related to allergy and that they cause pulmonary tract diseases. There are various house dust mites and among these Dermatophagoides pteronyssinus (Trouessart, 1897) and Dermatophagoides farinae (Hughes, 1961) are best known with regard to their medical importance and morphological characteristics. Skin tests are used to determine the role of mites in allergic diseases. The tests are performed by using D. pteronyssinus and D. farinae antigens. In order to study, the concordance between the skin test results and the presence of house dust mites, dust samples from the houses of 49 patients diagnosed with allergic diseases who underwent skin tests were taken to investigate the presence of mites in dust. House dust mites were determined in 23 (46.3%) of the houses. Mites were found in the houses of 15 (50.0%) of 30 patients with positive skin test results and 8 (42.0%) of 19 patients with negative skin test results. There was no significant difference between the skin test positivity and negativity in the presence of house dust mites (P>0,005). In conclusion, we thought that it was necessary to evaluate the presence of mites in the houses of people who have allergic symptoms even if they had negative skin test results.Öğe Serum zinc (Zn) levels in patients with giardiosis(2007) Taşkapan C.; Atambay M.; Aycan O.M.; Ozyalin F.; Yolo?lu S.; Miman O.; Daldal N.A decrease may occur in the levels of trace elements due to absorption deficiency resulting from giardiosis. This study was designed in order to reveal the difference in serum zinc levels between patients with giardiosis and healthy controls. Thirty one patients who were diagnosed as having giardiosis after detection of G. intestinalis and 31 healthy controls participated in the study. A significant decrease was observed in serum zinc levels of patients with giardiosis compared to those of controls (p < 0.0001). In conclusion, we suggest that parasitic diseases should also kept in mind in the differential diagnosis of cases characterized by low serum zinc levels.Öğe What is the Importance of Demodex folliculorum and D. brevis in the etiology of blepharitis?(Turkiye Klinikleri, 2013) Yula E.; Aycan Kaya Ö.M.; Atambay M.; Do?anay S.; Daldal N.; Ayhan Tuzcu E.Objective: It was reported that, Demodex folliculorum (DF) and D. brevis (DB) may cause an infestation in healthy subjects and, may be important for some eye problems such as blepharitis, or these parasites can bring the present disease into a more serious condition. In this study, we aimed to determine which demodex species' density increase in patients with blepharitis and whether the demodex density on face differs from healthy subjects. Material and Methods: In the study, the presence of demodex species was analyzed on eyelashes and faces of 96 patients with blepharitis and 197 healthy subjects. Samples taken through standard superficial skin biopsy technique and eyelash epilation were analyzed with the light microscope. Results: The mean age of the patients with blepharitis was 46.90±16.92 (15-89) years, whereas the mean age of control group was 39.54±17.61 (12-84) years. Among eyelash samples of the patients, 78 (81.25%) samples were found DF positive, whereas 25 (26.04%) of them were found DB positive; on the contrary 30 (15.22%) and 7 (3.55%) of the control group was DF and DB positive, respectively. Among the eyelash samples of the patients, the demodex incidence was statistically significantly higher compared to the control group (p<0.001). There was no significant difference in terms of demodex positivities on face. All patients who were demodex positive on the facial area were also found demodex positive for eyelash samples whereas 8 (24.2%) of eyelash samples were Demodex spp positive in the control group (p<0.001). Conclusion: The results of our study underline that the presence of Demodex spp on facial area may be one the important factors in the pathogenesis of blepharitis. In conclusion, we suggest that taking the demodicosis presence into consideration as a worsening factor may help in the management of blepharitis. © 2013 by Türkiye Klinikleri.
