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    Assessment of clinical phenotypic characteristics of patients with angioedema without wheals in a turkish population
    (Ocean Side Publications Inc, 2024) Cakmak, Mehmet Erdem; Bostan, Ozge Can; Kaya, Saltuk Bugra; Karakaya, Gul; Kalyoncu, Ali Fuat; Damadoglu, Ebru
    Background: Angioedema (AE) is defined fi ned as localized, self-limited swelling of subcutaneous tissues and mucosa. Objective: The aim of this study was to compare the phenotypic characteristics of patients with AE without wheals. Methods: This prospective study included adult patients with recurrent AE without wheals. Demographic and laboratory data of the patients were recorded in the patient fi le when they presented to the outpatient clinic between August 2018 and August 2020. The patients were contacted by phone to evaluate whether their AE had gone into remission between October 2023 and January 2024. The phenotypic characteristics of AE subtypes were compared. Results: The study included a total of 143 patients. The average age, age of onset of AE, rates of diabetes mellitus, hypertension and coronary artery disease were higher in the patients with angiotensin-converting enzyme inhibitor (ACEI) use related acquired AE (AAE) (AAE-ACEI). The rates of allergic rhinitis, drug allergy, atopy, and aeroallergen sensitivity, and the median total immunoglobulin E level were higher in patients with idiopathic histaminergic AAE (AAE-IH). The rate of face and/or perioral AE attacks was higher in the patients with AAE-ACEI, AAE-IH, and idiopathic non-histaminergic AAE. The rate of AE attacks in limbs, abdominal, genital and other parts of the body was higher in patients with hereditary AE (HAE). The baseline AE activity score was lower in the patients with AAE-IH and higher in the patients with HAE. In longterm follow-up, the remission rate of AE attacks was significant fi cant higher in patients with AAE-ACEI and AAE-IH. Conclusion: The phenotypic characteristic features of Turkish patients with AE without wheals may vary, depending on the underlying AE pathogenesis. C1 inhibitor level and function, complement C4 and C1q, and genetic tests contributed to the diagnosis; other laboratory tests did not contribute to the diagnosis.
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    Assessment of the use of adrenaline auto-injectors among a logia bez u i 1 adult patients at risk of anaphylaxis
    (Termedia Publishing House Ltd, 2022) Ozdemir, Ebru; Damadoglu, Ebru; Karakaya, Gul; Kalyoncu, Ali
    Introduction: Carriage and correct use of adrenaline auto-injectors (AAIs) by patients have been reported to be low. Aim: To evaluate the carriage rate of the EpiPen degrees and the usage skills of the adult patients. Material and methods: A total of 46 patients who had been previously prescribed EpiPen degrees were enrolled during a five-month period in our clinic. Data about the EpiPen degrees prescription indications and prescription date, the number of the device usage training sessions, the last training date, and the reasons for not carrying the device were obtained. Patients were practically evaluated with a trainer device. Results: Among 46 patients, 20 (43%) were female, and the mean age of the patients was 45 +/- 13 years (min.-max.: 20-67). EpiPen degrees prescription indication included Hymenoptera venom allergy in 44 patients, food allergy in one patient, and idiopathic anaphylaxis in one patient. Twenty-nine (63%) patients reported that they kept the device with them always, whereas 17 (37%) reported they did not. The most frequently stated reason for not carrying an EpiPen degrees was the thought that it was unnecessary (n = 6, 35%). Of 29 patients, 11 (38%) correctly demonstrated all the steps of the trainer device. The most frequent mistake was failing to remove the cap (n = 15, 83%). Conclusions: The significance of always carrying the device at all times should be emphasized, as should the importance of correct use of the device in patients' routine controls. Trainings given at least twice a year may be supported by reminders via telephone call or e-mail.