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    Frequency of hereditary thrombophilia, anticoagulant activity, and homocysteine levels in patients with hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome
    (Wiley, 2011) Dogan, Ovgu Ozkan; Simsek, Yavuz; Celen, Sevki; Danisman, Nuri
    Aim: The purpose of this study was to investigate the correlations between thrombophilic mutations, anticoagulant activity and hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome. Material and Methods: Twenty-five healthy pregnant women (control group) and 34 patients with HELLP syndrome (study group) were included in the study between April 2007 and January 2008. Homocysteine levels and activities of protein C, protein S and antithrombin III of the groups were compared. Frequency of factor V Leiden mutation, prothrombin 20210A mutation and C677 T mutation of methylenetetrahydrofolate reductase gene were also compared. Results: Frequencies of thrombophilic gene mutations of the two groups were not significantly different. Homocysteine levels were significantly higher in the study group. Protein C and protein S deficiencies of the two groups were similar. Antithrombin III deficiency was statistically higher in the patients with HELLP syndrome. Conclusion: The frequency of antithrombin III deficiency and homocysteine levels were higher in the patients with HELLP syndrome; however, there was no positive relationship between hereditary thrombophilic mutations and the disease. Larger prospective studies are needed to validate our findings.
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    Role of oxidative stress in preeclampsia and intrauterine growth restriction
    (Wiley, 2012) Mert, Ismail; Oruc, Ayla Sargin; Yuksel, Serdar; Cakar, Esra Sukran; Buyukkagnici, Umran; Karaer, Abdullah; Danisman, Nuri
    Aim: The aim of the present study was to evaluate the role of oxidative stress and DNA damage in preeclampsia and intrauterine growth restriction (IUGR). Material and Methods: Twenty-four patients with preeclampsia, 20 patients with IUGR fetus and 37 healthy pregnant women were enrolled in the study. The total oxidant status (TOS) and antioxidant status (TAS) of plasma were measured using a novel automated colorimetric measurement method. Sister chromatid exchange (SCE) and micronuclei analysis were performed on peripheral blood lymphocytes of cases and controls. Results: Women whose pregnancies were complicated with preeclampsia and IUGR had elevated levels of TOS and TAS when compared with healthy pregnant women (median TOS values: 9.73, 10.6 and 8.06, P = 0.001; median TAS values: 1 77, 1.54 and 1.44, P < 0.001, respectively). The frequencies of SCE were only found to be increased in women with IUGR fetus compared with healthy pregnant women (8.81 vs 7.5, respectively, P = 0.02). Multivariable linear regression analysis for both TOS and TAS showed a significant relation between these variables and uric acid. Conclusion: Increased oxidative stress and antioxidative defense mechanisms may contribute to disease processes both in preeclampsia and IUGR.