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    Bilateral disruption of corpus cavernosum with complete urethral rupture
    (Blackwell Publishing Asia, 2004) Soylu, A; Yilmaz, U; Davarci, M; Baydinc, C
    Penile fracture is a relatively rare condition. We report an unusual case of the bilateral disruption of the corpus cavernosum with complete urethral rupture resulting from blunt trauma during sexual intercourse. The subject underwent emergency surgery with preservation of erectile and voiding functions in the follow-up.
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    Increased nitric oxide production in the spermatic vein of patients with varicocele
    (Elsevier Science Bv, 2000) Ozbek, E; Turkoz, Y; Gokdeniz, R; Davarci, M; Ozugurlu, F
    Objective: To define the level of nitric oxide (NO) in the spermatic vein of patients with varicocele and its relation with male infertility. Materials and Methods: Following physical and color Doppler ultrasonographic examination, whole blood samples were drawn from a peripheral vein and a dilated varicocele vein from fourteen patients with clinically palpable varicocele (G2-3) before ligation. NO levels in the serum were determined as total nitrite by Greiss reaction and results were compared with Mann-Whitney U test. Results: NO levels in the internal spermatic vein were 36.05 +/- 8.92 mu mol/l, compared to 19.41 +/- 4.12 mu mol/l in the peripheral vein and the difference was statistically significant (p < 0.01). Conclusion: In view of our results, increased NO levels in the dilated varicocele vein might be responsible for spermatozoa dysfunction. Copyright (C) 2000 S. Karger AG, Basel.
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    The role of adrenomedullin in varicocele and impotence
    (Blackwell Science Ltd, 2000) Ozbek, E; Yurekli, M; Soylu, A; Davarci, M; Balbay, MD
    Objective To assess the levels of adrenomedullin (a vasodilatory peptide) in penile blood before and after injection with papaverine in impotent men, and in the internal spermatic vein in infertile patients with varicocele, comparing the results with levels in the brachial vein in the same patients. Patients and methods Intracavernosal levels of adrenomedullin were determined in 14 impotent men (with no vascular pathology, as assessed by colour Doppler ultrasonography) before and after papaverine-induced penile erection. The effect of needle puncture alone was assessed in eight control patients. The level of adrenomedullin was also measured in the internal spermatic vein and brachial vein in 14 infertile men with varicocele. Results The mean (SD) intracavernosal adrenomedullin levels in the 14 impotent men were significantly different between the flaccid and papaverine-induced erectile state, at 93.5 (33.0) and 135.8 (34.9) pmol/mL, respectively, (P < 0.05). Needle puncture alone had no effect on adrenomedullin levels. In men with varicocele, the adrenomedullin level of 139.0 (34.3) pmol/mL within the internal spermatic vein was significantly higher than that in the brachial vein, at 103.9 (37.6) pmol/mL (P < 0.05). Conclusion Injection with papaverine increases adrenomedullin release into penile blood; this release may be responsible for the increase in penile blood flow and penile erection. Higher levels of adrenomedullin within the internal spermatic vein of patients with varicocele may result from the retrograde flow of venous blood from the left adrenal gland and kidney. Further studies are needed to determine the role of adrenomedullin in male infertility and impotence.