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    Anxiety, depression and post-traumatic stress disorder symptoms in adolescents during the COVID-19 outbreak and associated factors
    (Wiley-Hindawi, 2021) Selcuk, Engin Burak; Demir, Arzu Caliskan; Erbay, Lale Gonenir; Ozcan, Ozlem Ozel; Gurer, Huseyin; Donmez, Yunus Emre
    Introduction Outbreaks of infectious diseases have negative effects on mental health. Currently, there is very little information about the psychological effects of the COVID-19 pandemic on adolescents and associated factors affecting their mental health. The aim of the present study is to determine the severity of anxiety, depression and post-traumatic stress disorder (PTSD) symptoms in adolescents during the COVID-19 outbreak, and to investigate the associated factors with these symptoms. Methods The present study was conducted with a total of 447 adolescents. Psychiatric symptoms were evaluated by the use of DSM-5 Level 2 Anxiety Scale, DSM-5 Level 2 Depression Scale and National Stressful Events Survey PTSD Short Scale. The association between age, gender, residential area, presence of COVID-19 in the participant, presence of COVID-19 in the family or environment and psychiatric symptoms were evaluated with linear regression analysis. Results The mean age of participants was 15.06, and 38.3% of the participants were men and 61.7% were women. The rate of participants with moderate or high levels of anxiety, depression and PTSD symptoms was 28%, 37.6% and 28.5%, respectively. High age and living in an urban area were associated with increased anxiety, depression and PTSD symptoms. In addition, female gender was associated with increased depression symptoms, and the presence of COVID-19 in the family or environment was associated with increased anxiety symptoms. Conclusion The present study shows that adolescents have serious levels of anxiety, depression and PTSD symptoms during the COVID-19 pandemic. These results emphasise the need for mental health interventions that are appropriate for the characteristics of this age group.
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    Aripiprazole-related alopesia: A case report
    (Inonu University Faculty of MediciInonu University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Malatya, Turkey, 2017) Demir, Arzu Caliskan; Ozcan, Ozlem
    [Abstract Not Acailable]
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    EVALUATION OF BLOOD ZONULIN LEVELS, INFLAMMATORY PROCESSES AND NEURONAL CHANGES IN CHILDREN WITH AUTISM SPECTRUM DISORDER
    (Medicinska Naklada, 2022) Kartalci, Gulsen; Demir, Arzu Caliskan; Kartalci, Sukru; Uremis, Nuray; Turkoz, Yusuf
    Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by symptoms such as limited, and repetitive behavior patterns and disordered social interaction and communication. The etiology of Autism Spectrum Disorder (ASD) is not clearly known, it has been emphasized that the immune-inflammatory system may also play a role in this disease. This study aimed to evaluate in intestinal permeability, food antigen-antibody levels, inflammatory processes, and neuron damage in patients with ASD. Subjects and methods: Thirty-five children between the ages of 3-12 with ASD and 35 controls were included in the study. Both participants' height and weight were measured, and the parents filled the Socio-demographic Data and the Gastrointestinal Systems (GIS) Symptoms Form. Venous blood samples were collected, and serum zonulin, anti-gliadin Ig A and Ig G, IL6, TNF-alpha, TGFJ3, S100B, and NSE levels were measured by ELISA. Results: Serum zonulin levels in the ASD group were found to be significantly lower. IL-6 and TGF-beta were found to be significantly higher in the ASD group. There was no difference between the two groups in terms of serum anti-gliadin Ig A and Ig G and TNF-alpha values. Also, GIS symptoms, NSE and SlOOB levels were found similar between two groups. Conclusions: Although findings showing low zonulin levels and increased inflammatory processes in ASD were found in this study, no difference was found in the parameters of brain damage. The findings show that intestinal permeability does not decrease in ASD and that inflammatory processes may play a role in ASD.
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    The nutritional behavior of children with autism spectrum disorder, parental feeding styles, and anthropometric measurements
    (Taylor & Francis Ltd, 2022) Demir, Arzu Caliskan; Ozcan, Ozlem
    Background Although autism spectrum disorder (ASD) is known to include problems relating to nutrition, information about nutritional behavior, caregiver feeding styles, and anthropometric measurements is still limited. Aims We aimed to assess the nutritional behavior, anthropometric measurements, and caregiver feeding styles of children with ASD. Method One hundred and four children with ASD and 100 controls were enrolled in the study. Children's weight and height were measured and recorded by the researchers. The Children's Eating Behavior Questionnaire, Parental Feeding Style Questionnaire, Development Assessment Form, and Sociodemographic Data Form were conducted by their caregivers. Results Children with ASD were difficult to feed as babies, experienced more problems in the transition to supplementary food, were more selective about food, and were fed diets with a more limited variety than the control group. The BMI z-scores for children with ASD were higher than those for children without ASD, while their height z-scores were lower. Children with ASD displayed more responsiveness to food, emotional overeating, enjoyment of food, desire for drinks, emotional undereating, and food selectivity behaviors, while the parents of these children were found to use more emotional feeding, instrumental feeding, and tolerance-controlled feeding styles than the parents of the controls. Conclusions Children with ASD are more selective about foods and have greater difficulty in switching to supplementary food. The BMI-z score for children with ASD is higher and the height-z score is lower. Children with ASD have different eating and feeding styles compared to children in the control group.
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    The relationship between smoking, alcohol, and substance abuse and psychiatric diseases among adolescents treated in a child and adolescent psychiatry inpatient unit
    (Turkish J Pediatrics, 2022) Demir, Arzu Caliskan; Donmez, Yunus Emre; Kartalci, Gulsen; Bingol, Muhammed Enes; Temelli, Gurkan; Ozcan, Ozlem
    Background. This study aimed to investigate the prevalence of smoking, alcohol, and substance abuse disorders among adolescents hospitalized in a university hospital child and adolescent psychiatry inpatient unit with different diagnoses, and to determine the rates of these disorders according to the mental illness diagnosis groups.Methods. The study was conducted with 346 adolescents aged 12-18 who had been hospitalized with any psychiatric diagnosis between September 2016 and January 2020 in the child and adolescent psychiatry inpatient unit. The study considered the psychiatric diagnoses, based on the results of the DSM-5-based psychiatric interview; sociodemographic and clinical characteristics; the psychopathology history of first-degree relatives; comorbidities; length of hospital stay; income levels, and smoking, alcohol, and substance abuse.Results. Twenty-four percent (n=83) of the participants had been smoking for 18 months or longer, 6.9% (n=24) were using alcohol, and 1% (n=28) were substance abusers. When the diagnosis distributions were examined, smoking was found to be higher in those with depressive disorders and trauma and related disorders, while smoking, alcohol, and substance use were found to be higher in the disruptive behavior disorder group. Smoking was found to be significantly lower in the obsessive-compulsive disorder group.Conclusions. Smoking, alcohol, and substance use among inpatient children and adolescents may worsen their existing psychopathology, so health professionals working in this field should consider this situation.
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    Testosterone and DHEA-S levels with chronic tic disorder in children
    (Elsevier Science Bv, 2016) Erbay, Lale Gonenir; Kartalci, Sukru; Ozcan, Ozlem Ozel; Demir, Arzu Caliskan; Uyumlu, Ayse Burcin; Kutuk, Meryem Ozlem
    The neurobiological basis of tic disorders is thought to be a series of interactions including genetic, environmental and gender related factors. Being male is thought to be an especially important risk factor in the pathogenesis of tics. Our aim in this study was to investigate gender-related hormones such as testosterone, dehydroepiandrosterone sulfate (DHEA-S) and cortisol in tic patients. A total of 26 patients who had not entered puberty and had been diagnosed with chronic tic disorder and 25 healthy children were included in the study, Serum total testosterone, cortisol and DHEA-S levels were measured and the relationship with clinical data was investigated. The testosterone and DHEA-S levels of the patient group were higher than that of the control group (P=0.019, P=0.025) but no statistical difference was found between the cortisol levels (P=0.642). No statistical correlation was found between total tic severity, general disturbance, movement tic subscale scores and the DHEA-S (P=0.77, P=0.45, P=0.819 respectively) and testosterone levels (P=0.954, P=0.669, P=0.909 respectively). The results of this study reveal an elevation of testosterone and DHEA-S levels in patients. Future studies with a larger number of patients are likely to help elucidate the importance of these androgens in tic disorder. (C) 2016 Elsevier Inc. All rights reserved.