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    A Cross-Sectional Study on the Relationship between the HEART Score and the Severity of CAD using the SYNTAX Score in Patients with NSTEMI Admitted to the Emergency Department: A Study from Turkey
    (Wolters Kluwer Medknow Publications, 2025) Pepele, M. S.; Aktas, I; Demiroz, O.; Derya, S.; Yildirim, E.; Bilen, M. N.; Demir, B.
    Background:The HEART score is a risk stratification tool for acute chest pain, evaluating history, ECG, age, risk factors, and troponin. The SYNTAX (synergy between percutaneous coronary intervention with TAXUS and cardiac surgery) score assesses the extent and complexity of coronary artery disease (CAD) and is widely used in patients undergoing coronary interventions.Aim:To determine the relationship between the HEART and SYNTAX scores in patients with non-ST elevation myocardial infarction (NSTEMI).Method:A total of 222 NSTEMI patients who underwent coronary angiography were included. The HEART score was calculated at admission, and all patients underwent angiography within 12 hours. SYNTAX was used to evaluate CAD severity. Patients were divided into two groups based on SYNTAX scores. Comparisons were made according to demographic data, laboratory findings, and risk factors. Variables associated with high SYNTAX scores were identified. A P value of < 0.05 was considered statistically significant.Results:The mean age was 63.67 +/- 11.89 years, and 74.77% of the patients were male. Patients with high SYNTAX scores had significantly higher HEART scores and more frequent diabetes and hypertension. High HEART score (OR: 3.09; 95% confidence intervals [CI]: 2.06-4.63; P < 0.001) and diabetes mellitus (OR: 4.57; 95% CI: 1.44-14.47; P = 0.010) were independently associated with high SYNTAX scores. A HEART score >7.5 predicted high SYNTAX scores with 82.1% sensitivity and 84.3% specificity (area under curve [AUC]: 0.892; P < 0.001). A strong positive correlation was found between HEART and SYNTAX scores (P < 0.001, R-2 =0.672).Conclusion:The HEART score was significantly associated with the severity and complexity of CAD in patients with NSTEMI.
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    Does hepcidin play a role in the pathogenesis of aphthae in Behcet's disease and recurrent aphthous stomatitis?
    (Wiley, 2014) Cicek, D.; Dagli, A. F.; Aydin, S.; Dogan, F. Baskaya; Dertlioglu, S. B.; Ucak, H.; Demir, B.
    BackgroundAphthae constitute one of the major signs in Behcet's disease (BD) and recurrent aphthous stomatitis (RAS). No scientific study has yet explored the relationship of hepcidins, which have antimicrobial effects, with RAS and BD. ObjectivesIn this study, we aimed to evaluate by immunohistochemistry whether hepcidin is synthesized by the salivary glands and to measure levels of prohepcidin and hepcidin (an antibacterial peptide) in the serum and saliva of patients with BD and RAS. MethodsThe study included 25 BD patients and 30 RAS patients, as well as a control group comprising 25 healthy individuals. Serum and saliva samples were collected at the same time from all subjects. Levels of prohepcidin and hepcidin were measured by ELISA. The presence of hepcidin in salivary glands was assessed by immunohistochemistry. ResultsHepcidin was localized in the striated ducts of the sublingual and parotid glands. Saliva prohepcidin and hepcidin levels were correlated with blood levels. Saliva prohepcidin levels were found to be lower in RAS patients than in BD patients and healthy controls (P<0.001 and P=0.007 respectively). In addition, RAS patients had lower saliva hepcidin levels than did the control group (P=0.03). ConclusionsThe lower serum and saliva prohepcidin and hepcidin concentrations found in RAS and BD patients indicate that hepcidin may be involved in the aetiopathogenesis of these diseases. Because it can be obtained non-invasively and easily, saliva may provide a useful alternative to serum in quantifying prohepcidin and hepcidin concentrations.