Yazar "Demir, Bilgehan" seçeneğine göre listele
Listeleniyor 1 - 8 / 8
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Can serum interleukin 34 levels be used as an indicator for the prediction and prognosis of COVID-19?(Public Library Science, 2024) Karahan, Dogu; Bolayir, Hasan Ata; Bolayir, Asli; Demir, Bilgehan; Otlu, Oender; Erdem, Mehmet; Perera, NilankaObjective Interleukin 34 (IL-34) is a molecule whose expression is increased in conditions such as autoimmune disorders, inflammation, and infections. Our study aims to determine the role of IL-34 in the diagnosis, follow-up, and prognosis of Coronavirus Disease-19 (COVID-19).Method A total of 80 cases were included in the study as 40 COVID-19 positive patient groups and 40 COVID-19 negative control groups. The COVID-19-positive group consisted of 20 intensive-care unit (ICU) patients and 20 outpatients. Serum IL-34, c-reactive protein (CRP), ferritin, D-dimer, troponin I, hemogram, and biochemical parameters of the cases were studied and compared between groups.Results IL-34 levels were significantly higher in the COVID-19-positive group than in the negative group. IL-34 levels increased in correlation with CRP in predicting the diagnosis of COVID-19. IL-34 levels higher than 31.75 pg/m predicted a diagnosis of COVID-19. IL-34 levels did not differ between the outpatient and ICU groups in COVID-19-positive patients. IL-34 levels were also not different between those with and without lung involvement.Conclusion While IL-34 levels increased in COVID-19-positive patients and were successful in predicting the diagnosis of COVID-19, it was not found to be significant in determining lung involvement, risk of intensive care hospitalization, and prognosis. The role of IL-34 in COVID-19 deserves further evaluation.Öğe Datura Stramonium'a Bağlı Gelişen İntoksikasyon(2014) Oğuztürk, Hakan; Turtay, Muhammet Gökhan; Sarıhan, Mehmet Ediz; Bayhan, İrfan; Demir, Bilgehan[Abstract Not Acailable]Öğe Effect of earthquakes on spontaneous pneumothorax development(2020) Savrun, Atakan; Demir, Bilgehan; Savrun, Seyda T; Gokcen, Emre; Caltekin, Ibrahim; Yasar Teke, Hacer; Korkma, HilalAim: This study researched the effect of earthquakes, affecting meteorological parameters by causing pressure changes in the atmosphere, on the development of spontaneous pneumothorax (SP) and which periods after earthquakes were risky in terms of SP development. Material and Methods: The study retrospectively investigated the files of 117 cases, 4 females (3.4%) and 113 males (96.6%) with spontaneous pneumothorax diagnosis in the emergency service of our hospital within a five-year period. The day patients attended hospital was accepted as the day of pneumothorax formation. Meteorological data for the study period was obtained from the Republic of Turkey General Directorate of Meteorology. Earthquake data for the study period were obtained from the Earthquake Department of the Republic of Turkey Disaster And Emergency Management Presidency website. The correlation of the changes in air temperature, humidity and pressure values of the day on which SP occurred compared to the previous day was investigated with SP. Additionally, risk analysis was performed for the correlation of SP formation time with earthquake days and the time interval after earthquakes.Results: Within the study duration, the number of SP cases on the same day as earthquakes in the region was 27, with earthquake magnitude a minimum of 2.10 and maximum of 4.00 with mean of 2.5±0.47 calculated. Cases attending on days without earthquakes (n=90) were assessed in terms of how many days after the last earthquake they attended and mean duration was 8.14±8.03 days, with attendance due to pneumothorax a minimum of 1 day and maximum 44 days later. As the duration after an earthquake lengthened, there was a statistically significant reduction in the number of attendances.Conclusion: SP is a clinic that can be diagnosed initially by doctor suspicion. In our study, we identified earthquakes were effective on pneumothorax development. As a result, we believe it is necessary to initially consider SP diagnosis for cases attending the emergency department with dyspnea and chest pain complaints in this risky period.Öğe Evaluation of red blood cell distribution width and mean platelet volume levels in hypertensive and non-hypertensive epistaxis patients(2020) Caltekin, Ibrahim; Demir, Bilgehan; Albayrak, Levent; Atik, Dilek; Gokcen, Emre; Savrun, Atakan; Kaya, Hasan BurakAim: We investigated the development of epistaxis and the effect of red blood cell distribution (RDW) and mean platelet volume (MPV) levels in hypertensive patients compared to non-hypertensive patients. Epistaxis is an urgent rhinologic condition that may manifest itself as recurrent hemorrhages in small quantities or life-threatening hemorrhages. It is known that epistaxis does not develop in every hypertensive patient.Material and Methods: In this retrospective study, the participants were divided into four groups as follows: Group 1 hypertensive epistaxis, Group 2 isolated epistaxis, Group 3 isolated hypertension, Group 4 control. RDW and MPV values were obtained from complete blood count (CBC) samples.Results: There was a statistically significant difference in RDW and MPV blood parameters between all groups (p=0.02). When RDW and MPV blood parameters of Group 1 with hypertensive epistaxis and Group 3 with isolated hypertension were evaluated, there was a statistically significant difference between these two groups in both parameters (p = 0.000, p = 0.011).Conclusion: In our study, we showed that the decrease in RDW and MPV values among the hematological parameters increases the association of epistaxis with hypertension in hypertensive patients compared to non-hypertensive patients.Öğe Pulmonary embolism: single and multiple risk factors(Scientific Publishers India, 2017) Demir, Bilgehan; Oguzturk, Hakan; Turtay, Muhammet Gokhan; Colak, Cemil; Demir, Nur Kaplan; Gurbuz, SukruPurpose: This study aims to determine the effect of the coexistence of multiple risk factors on prevalence of pulmonary embolism (PE), which has a high mortality. Method: We conscripted 220 patients who submitted to the emergency department of Turgut Ozal Medical Center (TOTM) between January 2013 and January 2014. Of these, 110 patients were diagnosed with pulmonary embolism and they showed symptoms such as pain in the chest, sweating, coughing, hemoptysis and syncope, and 110 were healthy controls. A prospective study was conducted to obtain information on the patients regarding age, cerebrovascular disease (CVD), coronary artery disease (CAD), congestive heart failure (CHF), diabetes mellitus (DM), hypertension (HT), smoking, hormone replacement treatment (HRT), pregnancy, chronical obstructive pulmonary disease (COPD), previous surgical interventions and cancer history. We also analyzed various blood values such as white blood cell (WBC) count, hemoglobin, hematocrit, thrombocyte, glucose, urine, creatinine, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), Cholesterol, Very Low Density Lipoprotein (WLDL), INR, and CRP. We examined Protein C, Protein S and AT3 levels of all patients. We obtained electrocardiography (ECG), dynamic computed tomography, electrocardioscopy (ECHO) and venous lower extremity Doppler ultrasonography from all patients. Findings: Of 220 patients, 112 were male (50.9%) and 108 female (49.1%). We found DM (p: 0.017), HT (p: 0.020), CVD (p: 0.026) smoking (p: 0.014), dyslipidemia (p: 0.408) values statistically significant. We found only Protein S (p: 0.0001) and Troponin (p: 0.0002) levels significant among Protein C, Protein S, AT3, INR, Fibrinogen, D-dimer, troponin, blood gas parameters. We also found Doppler values significant (p: 0.001) among other radiologic parameters. When we applied univariate regression analysis on the risk factors, we determined hypertension (50.0%) and smoking (32.7%) as the most risky for PE. Other risk factors were surgical intervention, CVD, CHF, CAD, DM, COPD, CA, pregnancy and HRT, respectively. Most common symptom was the pain in the chest (88.2%). We found that DM and smoking poses greater risk together (OR: 8.67). Besides OR values for HT-CHF, DM-COPD, DM-pregnancy, and COPD-smoking pairs was 5.48, 5.14, 3.98, and 3.73, respectively. OR value was highest for syncope and sweating symptom pair (4.039). Conclusion: We found that the prevalence of PE increase in case of coexistence of risk factors. Thus even small symptoms can help to diagnose and prevent this deadly disease. In this regard, a careful doctor can make a big difference. Following studies may concentrate on educating the patients.Öğe Pulmoner embolide risk faktörleri ve çoklu risk faktörü varlığında pulmoner emboli gelişme riskinin belirlenmesi(İnönü Üniversitesi, 2015) Demir, BilgehanPulmoner emboli (PE) sık karşılaşılan bir kardiyovasküler acil durum olup, dünya çapında milyonlarca insanı etkilemektedir. Akut bir tablo olmasına rağmen sağ kalp yetmezliği yapabilir. Tedavi edilmediği zaman mortal seyreden ve günümüzde görülme sıklığı artan bir hastalık konumundadır. Bu nedenle bilinen risk faktörlerinin varlığında ve klinik şüphe durumunda üzerinde hassasiyetle durulması gerekliliği mevcuttur. Çalışmamızda pulmoner risk faktörlerinin belirlenmesi ve birden fazla risk faktörü varlığında PE geçirme riskinin belirlenmesi amaçlanmıştır. PE risk faktörleri içinde hipertansiyon (HT), dislipidemi, sigara içme, cerrahi operasyon hikayesi, serebrovasküler hastalik (SVO), konjestif kalp yetmezlik (KKY), diabetes mellitus (DM), kronik obstrüktif akcier hastalk (KOAH), kanser (CA), gebelik ve hormon replasman tedavisi (HRT) kullanımı gibi hastalıklar belirlenmiştir. Çalışmamızda acil serviste PE tanısı konmuş 110 hasta ve aynı risk faktörlerini taşıyan fakat PE tanısı konulmayan kontrol grubu olarak 110 hasta incelendi. Hasta grubunun 54'ü kadın, 56'sı erkek hasta, kontrol grubunda is 54'ü kadın ve 56'sı erkek hastalardan oluşmaktaydı. Çalışmamızda DM (p:0.017), HT (p:0.020), SVO(p:0.026) sigara (p:0.014), dislipidemi (p:0.408) varlığı istatistiksel olarak anlamlı bulunmuştur. Çalışmamızda Protein C, Protein S, AT3, INR, Fibrinojen, D-dimer, Troponin, kan gazı parametrelerinden sadece Protein S (p:0.0001) ve Troponin düzeyi (p:0.0002) anlamlı bulunmuştur. Ayrıca radyolojik olarak bakılan Doppler ve Elektrokardiyografi (EKO)' den sadece doppler (p:0.001) pozitifliği anlamlı bulunmuştur. Risk faktörlerinin tek değişkenli regresyon analizinde PE için en yüksek riske sahip faktörün hipertansiyon (%50.0) ve sigara(%32.7) olduğu tespit edildi. Diğer risk faktörlerinde görülme sıklığı sırası ile cerrahi müdahale öyküsü, SVH, KKY, KAH, DM, KOAH, CA varlığı ve gebelik/ HRT kullanımı olarak izlendi. Semptomlar arasında en sık göğüs ağrısı (%88.2) olarak izlendi. İkili risk faktörlerinden DM ile sigara içiciliği birlikteliğine ait OR:8.67 olup tek başlarına neden olduklarında riskten çok daha fazlası riski oluşturdukları görüldü. Ayrıca HT ile KKY birlikteliğinde OR:5.48, DM ile KOAH birlikteliğinde OR:5.14, DM ile gebelik OR:3.98, KOAH ve sigara içiciliği OR:3.73 olarak tespit edildi. İncelenen tüm semptomlar içinde, senkop ile terlemenin bir arada olduğunda OR:4.039 ile en yüksek orana sahip olduğu tespit edildi. Sonuç olarak bu çalışmada PE risk faktörlerini ve bu faktörlerin; riski artırma oranlarını, ikili risk faktörü varlığında PE gelişme riskinin tek başına neden olduklarından çok daha fazla artırdıklarını ortaya koymuştur. Bu sonuçlar; PE geçirme olasığının en yüksek olduğu birlikteliğin, önlenebilir risk faktörlerinden olması nedeni ile erken dönemde saptanması ve tedavilerin erken dönemde planlanmasının önemini göstermiştir.Öğe Slient death(2019) Demir, BilgehanÖğe The value of laboratory markers in the differential diagnosis of acute vestibular syndrome(2021) Gokcen, Emre; Demir, Bilgehan; Savrun, Seyda TubaAim: Stroke is one of the leading and most challenging problems in distinguishing between central and peripheral causes of acute vestibular syndrome. This study aims to evaluate the potential utility of neutrophil to lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and gamma-glutamyl transferase (GGT) levels in the differential diagnosis of acute vestibular syndrome. Materials and Methods: This retrospective study included 152 patients diagnosed with vestibular neuritis (VN) and posterior circulation ischemic stroke (PCIS) within the scope of the isolated acute vestibular syndrome (AVS: vertigo, nystagmus, nausea-vomiting, postural instability, and intolerance of head movements). Of all these patients, we listed the ones having normal MRI findings and diagnosed with VN in the department of otorhinolaryngology. The diagnosis of stroke was made through neuroimaging methods (CT and MRI). NLR and GGT levels were compared among the patients diagnosed with VN and PCIS.Results: GGT, NLR, PLR levels were significantly higher in the patients with the PCIS group (p0.05). The AUC (area under the curve) and optimal cutoff values for NLR, PLR, and GGT were analyzed by ROC analysis. According to these results, the diagnostic value of NLR was higher in predicting stroke (AUC: 0.741; 95%CI: 0.652-0.829, p0.001)Conclusion: As a result, NLR, GGT, and PLR can be useful biomarkers for deciding in favor of stroke in the differential diagnosis of VN.
