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    Clinical characteristics and therapeutic outcomes of paroxysmal nocturnal hemoglobinuria patients in Turkey: a multicenter experience
    (Springer, 2021) Goren Sahin, Deniz; Akay, Olga Meltem; Keklik, Muzaffer; Okan, Vahap; Karakus, Abdullah; Demir, Cengiz; Erkurt, Mehmet Ali
    The aim of this study is to collect paroxysmal nocturnal hemoglobinuria (PNH) patient data from hematology centers all over Turkey in order to identify clinical features and management of PNH patients. Patients with PNH were evaluated by a retrospective review of medical records from 19 different institutions around Turkey. Patient demographics, medical history, laboratory findings, and PNH-specific information, including symptoms at the diagnosis, complications, erythrocyte, and granulocyte clone size, treatment, and causes of death were recorded. Sixty patients (28 males, 32 females) were identified. The median age was 33 (range; 17-77) years. Forty-six patients were diagnosed as classic PNH and 14 as secondary PNH. Fatigue and abdominal pain were the most frequent presenting symptoms. After eculizumab became available in Turkey, most of the patients (n = 31/46, 67.4%) were switched to eculizumab. Three patients with classic PNH underwent stem cell transplantation. The median survival time was 42 (range; 7-183 months) months. This study is the first and most comprehensive review of PNH cases in Turkey. It provided us useful information to find out the differences between our patients and literature, which may help us understand the disease.
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    The patient presenting with renal failure due to multiple myeloma associated with celiac disease: Case report
    (Uluslararası Hematoloji-Onkoloji Dergisi, 2011) Şahin, İdris; Demir, Cengiz; Alay, Murat; Eminbeyli, Lokman
    Abstract: Çölyak hastalığı (ÇH), oto-immün kökenli, glutene karşı hassasiyet sonucu ince bağırsak mukozasında inflamasyon ve villüs atrofisi sonucu gelişen malabsorbsiyona bağlı olarak intestinal ve ekstraintestinal bulgularla karakterize bir hastalıktır. ÇH malignite ve böbrek yetmezliği gelişimi için önemli bir risk faktörüdür. ÇH olanlarda başta lenfoma ve gastrointestinal sistem tümörleri olmak üzere malignite sıklığı artmıştır. Makalemizde, kronik böbrek yetmezliği (KBY) tanısı ile izlenen, multipl miyeloma tanısı konulan ve ÇH saptanan 65 yaşında erkek hasta sunulmuştur. Olgumuz literatürde bildirilen ÇH’na eşlik eden ilk multipl miyelom olgusudur.
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    Primary central nervous system lymphoma in daily practice and the role of autologous stem cell transplantation in relapsed disease: A retrospective multicenter study
    (Pergamon-Elsevier Science Ltd, 2016) Erkurt, Mehmet Ali; Berber, Ilhami; Tekgunduz, Emre; Dogu, Mehmet Hilmi; Korkmaz, Serdal; Demir, Cengiz; Yilmaz, Mehmet
    We investigated the course of 54 patients presenting with primary central nervous system lymphoma, who were treated in daily practice. The patients were treated with chemotherapy and/or radiotherapy and/or intrathecal chemotherapy. At a median follow-up period of 23 months (range 1-71), median relapse-free survival (RFS) and overall survival (OS) were not reached. Estimated 2-year RFS and OS rates were 42% and 48%, respectively. Ten relapsed PCNSL patients underwent ASCT. Complete remission rate of these patients was 40%, with 20% treatment-related mortality. Estimated 2-year RFS and OS rates were 37% and 40%, respectively. The prognosis of patients with PCNSL, who received off-study treatment, is still dismal. (c) 2016 Elsevier Ltd. All rights reserved.