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  • Küçük Resim
    Öğe
    Comparative bibliometric analysis of fertility preservation
    (2019) Yildirim, Engin; Demir, Emre
    Aim: Fertility preservation (FP) has become an important issue for both women and men, due to oncological therapies, gonadotoxic treatments, surgeries, and infertility. The aim of this study is to investigate the publications related to FP, identify the top effective countries and journals, top productive researchers, and trend topics. Material and Methods: The data of this study were obtained using the Thomson Reuters WoS (Thomson Reuters, New York, NY, USA) database, separately for females and males. In the bibliometric analysis, ‘fertility preservation’ was used as a keyword. VOSviewer (Version 1.6.6) was utilized for bibliometric network visualizations. SPSS was used for the statistical analyses (Version 22.0)Results: Analysis results of the keywords used for men indicated 817 publications and for females indicated 2531 publications totally. The United States of America (USA) was the top country for the publications about both genders. The top three research fields for both genders were Obstetrics and Gynecology, Reproductive Biology, and Oncology. The journals that contributed to the literature most were Fertility and Sterility and Human Reproduction respectively in both gender categories. The correlation between the number of total fertility preservation articles and total cancers,Gross Domestic Product-World Bank (GDP-WB), Gross Domestic Product-International Monetary Fund (GDP-IMF), Human Development Index (HDI), and Internet Users (IU) was significant (r=0.482, p=0.017; r=0.609, p0.001; r=0.620, p0.001; r=0.365, p=0.043; r=0.479, p=0.006). Conclusion: It has been determined that researches on the protection of the fertility of cancer patients and infertile patients have increased from past to present. Also, it is observed that the economies of countries have an active role in research productivity.Keywords: Bibliometrics; fertility preservation; female; male.
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    An interactive web application for propensity score matching with R shiny; example of thrombophilia
    (2020) Demir, Emre; Kose, Serdal Kenan; Akmese, Omer Faruk; Yildirim, Engin
    Aim: The aim of this study was to develop a new web-based R Shiny package that calculates propensity score using many algorithms such as logistic regression, machine learning, and performs matching analysis with balance evaluation. In addition, it was aimed to explain the process of matching analysis on a real data set by comparing the number of live births between those with methylenetetrahydrofolate reductase (MTHFR) homozygous mutations and those without mutations in women hospitalized due to abortion in the gynecology and obstetrics clinic.Material and Methods: The web-based application was developed using R shiny. The “matchIt” library was used for matching analysis and PS prediction. The “cobalt” library was used to evaluate balance and generate plots.Results: The abortion variable, which was statistically significantly different in the groups before matching (p=0.010), was similar in the groups after matching (p=0.743). In addition, when the descriptive statistics and p values of the other variables were examined, it was seen that almost full balance was achieved after matching and the confounder variables were similar distributed in groups. After matching analysis, it was determined that the result variable “livebirths” did not show statistically significant difference in the groups (p=0.864).Conclusion: In this study, we developed an interactive web application for matching analysis based on propensity score. It is thought that this application will facilitate the studies of the researchers.
  • Küçük Resim
    Öğe
    Is there a relationship between serum kisspeptin levels and endometrial polyps in women with premenopausal status
    (2019) Yildirim, Engin; Derici, Mehmet Kursat; Simsek, Omer Yavuz; Demir, Emre
    Aim: Endometrial polyps are frequently associated with abnormal uterine bleeding. The kispeptin family is one of the peptides that play a role in reproductive functions and whose expression varies in various uterine pathologies. The aim of the study was to determine the relationship between serum Kisspeptin levels and endometrial polyps in women with premenopausal status.Material and Methods: The blood was collected prior to endometrial sampling from women admitted to the hospital due to abnormal uterine bleeding. According to the pathology results, patients were identified as polyp group (n=38) (endometrial polyps) and control group (n=50) (normal endometrial findings). Kisspeptin-54 levels were determined by ELISA method from serum obtained from venous blood. Results: There were no difference was found between the patients’ age, body mass index, gravida, para, abortus and the number of living children were compared (p>0.05). There was no statistically significant difference between the groups in terms of follicle stimulating hormone, luteinizing hormone and thyroid stimulating hormone values (p>0.05). Plasma kisspeptin (1.84±0.93 ng/dL and 1.32±0.47 ng/dL, p= 0.008) and estradiol (90.34±13.02 pg/mL and 81.75±12.36 pg/mL, p=0.002) levels were significantly higher in the polyp group than in the control group. After the Receiver Operating Characteristic (ROC) analysis the area under the curve (AUC) was 1.26 (p= 0.08), (95% CI, 0.550-0.782). The sensitivity value was 0.684 (0.512-0.819), the specificity was 0.620 (0.471-0.750).Conclusion: The serum Kisspeptin-54 and estradiol levels were found higher in patients with endometrial polyps.Keywords: Abnormal uterine bleeding; endometrial polyps; kisspeptin.