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    Overall survival and prognostic factors in lung cancer patients with brain metastases
    (2020) Demir, Fadime; Yanarates, Ahmet; Budak, Emine
    Aim: The aim of this study was to investigate overall survival in patients with lung cancer with brain metastasis. Our other aim was to investigate prognostic value of the maximum standardized uptake value (SUVmax) of primary tumor on 18Fluorine-fluorodeoxyglucose positron emission tomography / computed tomography (18F-FDG PET / CT) FDG PET / CT and other clinicopathological parameters. Material and Methods: Fifty-eight patients with lung cancer who underwent for oncologic purpose and had metastatic lesions in the brain were included in the study. The location of the primary lung mass and whether other organ metastases presence was evaluated on the 18F-FDG PET / CT. In axial images, the volume of interest (VOI) was plotted semi-automatically to include lung tumor tissue and SUVmax of the primary lung tumor was measured. Survival analyzes were performed with Kaplan-Meier survival analysis. The prognostic value of the parameters was evaluated using Cox regression analysis.Results: Of the 58 patients included in the study, 6 (10%) were female and 52 (90%) were male. The mean age was 64.8 ± 9.5 years. The mean SUVmax of primary tumor was 10.4 ± 4.5. Median survival was 7 months. Patient age and localization of the primary tumor were prognostic factors for survival in univariate analysis, whereas sex, SUVmax of primary tumor, presence of distant metastasis outside the brain, histologic subtype, surgical status of the metastatic brain mass and treatment type were not. Overall survival was lower in patients with primary tumor located in the left lung than in the right lung.Conclusion: In conclusion, age and localization of primary tumor are prognostic factors, whereas SUVmax of primary tumor does not appear to be a prognostic factor in lung cancer patients with brain metastases.
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    Prognostic value of F-18 fluorodeoxyglucose uptake in primary tumor and reticuloendothelial system in patients with head and neck cancer
    (2021) Demir, Fadime
    Aim: The aim of this study was to investigate the prognostic value of FDG uptake in primary tumor and reticuloendothelial system at 18 Fluorine-fluorodeoxyglucose positron emission tomography / computed tomography (18F-FDG PET / CT) in patients with head and neck cancer.Materials and Methods: A total of 56 head and neck cancer patients who underwent 18F-FDG PET / CT imaging in our clinic for staging were included in study. A circular volume of interest (VOI) was drawn which include tumor tissue on axial images and thereafter SUVmax value of the primary tumor was measured. Bone marrow SUVmax was measured at Lumbal 3-5 th vertebraes. Bone marrow-to-liver uptake ratio (BLR) value was calculated by dividing the bone marrow SUVmax value to liver SUVmax. Bone marrow-to-spleen uptake ratio (BSR) ratio value was calculated by dividing bone marrow SUVmax value to the spleen SUVmax.Results: Forty-five were male and 11 were female of the 56 patients included in the study. The average age was 62.71 ± 14.3. The SUVmax value of primary tumor and age had a significant predictive value in terms of overall survival (p = 0.027 and p = 0.037, respectively). There was a significant difference in overall survival when using 13.6 cut off for SUVmax and 65.5 cut off for age (p = 0.005, p = 0.019, respectively). Age (≥65.5), distant metastasis and SUVmax of primary tumor (≥13.6) values were independent prognostic factors in the multivariate analysis. The bone marrow SUVmax value and BLR and BSR ratios of the patients did not have a significant prognostic value in both univariate and multivariate analysis.Conclusion: The SUVmax value of the primary tumor in 18F-FDG PET / CT in patients with head and neck cancer, had both predictive and independent prognostic value. Bone marrow SUVmax, BLR and BSR values which shows FDG uptake on RES system, were not predictive and prognostic.