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Öğe THE EFFECT OF MELATONIN ON THE EXPERIMENTALLY PRODUCED ALZHEIMER IN RATS AND RELATIONSHIP WITH FEZ1 GENE EXPRESSION(Wiley, 2017) Demir, M.; Yilmaz, U.; Sandal, S.; Colak, C.; Cigremis, Y.; Tekedereli, I.[Abstract Not Available]Öğe EFFECTS OF INTRACEREBROVENTRICULAR FGF21 INFUSION ON THE ENERGY METABOLISM(Wiley, 2017) Yilmaz, U.; Tekin, S.; Demir, M.; Cigremis, Y.; Sandai, S.[Abstract Not Available]Öğe Is there a new pathway relationship between melatonin and FEZ1 in experimental rat model of Alzheimer's disease?(Comenius Univ, 2019) Demir, M.; Yilmaz, U.; Colak, C.; Cigremis, Y.; Ozyalin, F.; Tekedereli, I; Sandal, S.Alzheimer's disease (AD) is a progressive neurodegenerative disease. This study was performed to determine the possible relationship between melatonin, which is known to play a role in the neuro-protective mechanism in AD, and fasciculation and elongation protein zeta 1 (FEZ1). Thirty male rats were included and separated into 3 groups (n = 10) as vehicle (artificial cerebrospinal fluid), streptozotocin (STZ) and STZ+melatonin (MLT). Two intracerebroventricular (icv) injections of 3 mg/kg STZ were made 48 hours apart. MLT injections were implemented for 14 days (ip; 10mg/kg/day). The Morris Water Maze (MWM) test was performed and rats were sacrificed to assess FEZ1 gene expression and protein levels from the hippocampus tissues and serum levels of noradrenaline (NA), dopamine and serotonin were determined from the blood samples. It was determined that the FEZ1/beta-actin protein ratio in the STZ group was significantly higher than that of the Vehicle group (p < 0.05) and in the MLT-administered group, the protein levels were decreased to the levels observed in the Vehicle group. Serum NA levels of STZ and STZ+MLT groups were found to be lower than those in the Vehicle group, while no difference was found regarding dopamine and serotonin levels. These findings show that reversal of increased FEZ1 levels in AD-induced rats with melatonin administration is the evidence of the effect of melatonin through FEZ1 in AD (Tab. 2, Fig. 5, Ref. 67).Öğe Recurrence and occurrence of hepatocellular carcinoma following ledipasvir and sofosbuvir treatment for chronic hepatitis C in patients with advanced liver disease: Turkish multi-center early access program(Elsevier Science Bv, 2018) Idilman, R.; Demir, M.; Aladag, M.; Kaymakoglu, S.; Erol, C.; Cavus, B.; Iliaz, R.[Abstract Not Available]
