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    The frequency of laryngeal involvement in lipoid proteinosis patients
    (2019) Aksoy, Mustafa; Yukkaldiran, Ahmet; Yesilova, Yavuz; Demir, Mahmut; Iynen, Ismail; An, Isa; Tanrikulu, Osman
    Aim: Lipoid proteinosis (LP) is a rare autosomal recessive disorder that occurs with the accumulation of hyaline substance in oral cavity, laryngeal mucosa and skin. The aim of this study was to investigate the incidence of laryngeal involvement in patients with LP which have hoarseness and skin lesions, and the areas of hyaline substance accumulation in the larynx. Material and Methods: In this study, 21 patients who were admitted to our Dermatology outpatient clinic between January 2013 and December 2017 and diagnosed as LP with punch biopsy were evaluated. Laryngeal imaging was performed in otorhinolaryngology clinic, and the frequency of larynx involvement and the areas of hyaline accumulation in the larynx were evaluated. Results: Twenty-one patients with hoarseness and diagnosed by skin biopsy as LP were included in the study. Thickening of the vocal cords in 21 patients (100%); thickening and hypertrophic changes of arytenoids in 13 patients (61.9%); thickening and hypertrophic changes of the interarytenoid area in 10 patients (47.6%); thickeningand hypertrophic changes of epiglottis in 3 (14.3%) patients; hypertrophic changes and thickening of the aryepiglottic fold in 3 patients (14.3%); thickening and hypertrophic changes of ventricular folds in 2 patients (9.5%) were observed. Conclusion: In our study, similar to the data in the literature, the pathological changes were most frequently seen in the vocal cords and the least in the ventricle band, aryepiglottic fold and epiglottis. In order to better understand the laryngeal involvement and the areas of involvement in LP patients, studies with more patients are needed.
  • Küçük Resim
    Öğe
    Sociodemographic characteristics and dynamic thiol/disulfide homeostasis in pediatric patients presenting with scorpion sting
    (2019) Deveci, Serhat; Demir, Mahmut; Guzelcicek, Ahmet; Kirmit, Adnan
    Aim: Poisoning from scorpion sting is an important public health problem, and may cause disability and death especially in childhood. In our study, we aimed to evaluate the sociodemographic characteristics, clinical findings, laboratory results and dynamic disulfide/thiol homeostasis as oxidative stress factor of pediatric patients presenting with scorpion sting complaints to our hospital.Material and Methods: Forty patients in the 0-18 age group who admitted to the Pediatric Emergency Outpatient Clinic due to scorpion sting intoxication were included in the patient group, and 38 healthy children in the same age group were included in the control group. Patients’ sociodemographic characteristics, clinical and laboratory findings, treatment modalities and the outcomes were examined. In addition, thiol/disulfide levels in the serums of patients were studied with a new method developed by Erel et al.Results: Forty pediatric patients (57.5% male and 42.5% female) presenting with scorpion sting complaints were included in the study. Results: There was no statistically significant difference among patient and control group with regards to the mean native thiol levels. While it was found that the levels of the total thiol, disulfide, disulfide/native thiol and disulfide/total thiol were statistically significant higher in the patient group, the native thiol/total thiol ratio was found to be lower at a significant level. Conclusion: The scorpion sting incidents are still an important health problem in Turkey. In children with scorpion sting, the thiol/disulfide homeostasis was observed to shift towards the disulfide side, i.e. to the right, indicating an increase in oxidative stress.