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  • Küçük Resim
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    Age related risk factors associated with severity of atopic dermatitis in children
    (2019) Celiksoy, Mehmet Halil; Topal, Erdem; Demir, Osman
    Aim: Atopic dermatitis is a chronic, relapsing, and pruritic dermatitis, which generally develops in early childhood, and has a characteristic age-dependent distribution. To review age related risk factors associated with severity of atopic dermatitis in children. Material and Methods: The medical records of 206 pediatric patients with the diagnosis of atopic dermatitis between August 2015 and August 2017 were reviewed retrospectively. Results: The study included two hundred six patients who were diagnosed with atopic dermatitis (118 males, 88 females, median age: 20 months). The disease was found to have a more severe course in patients who were breastfed for less than six months, who were exposed to cigarette smoke, who had a food allergen and a history of atopy in the family (p<0.047, 0.046, 0.032, 0.012, respectively) in the 0-2 age group. The disease was found to have a more severe course in patients who had aeroallergen sensitivity, high serum total IgE level, who had eosinophilia, and low socioeconomic level (p<0.016, 0.023, 0.038, 0.032, respectively) in the patient older than 2 years old. Conclusion: While parental atopy and diet determine the severity of the disease in the early period of life, environmental factors have a more obvious role in later periods.
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    Age related risk factors associated with severity of atopic dermatitis in children
    (2019) Topal, Erdem; Çeliksoy, Mehmet Halil; Demir, Osman
    Abstract: Aim: Atopic dermatitis is a chronic, relapsing, and pruritic dermatitis, which generally develops in early childhood, and has a characteristic age-dependent distribution. To review age related risk factors associated with severity of atopic dermatitis in children.Material and Methods: The medical records of 206 pediatric patients with the diagnosis of atopic dermatitis between August 2015 and August 2017 were reviewed retrospectively.Results: The study included two hundred six patients who were diagnosed with atopic dermatitis (118 males, 88 females, median age: 20 months). The disease was found to have a more severe course in patients who were breastfed for less than six months, who were exposed to cigarette smoke, who had a food allergen and a history of atopy in the family (p<0.047, 0.046, 0.032, 0.012, respectively) in the 0-2 age group. The disease was found to have a more severe course in patients who had aeroallergen sensitivity, high serum total IgE level, who had eosinophilia, and low socioeconomic level (p<0.016, 0.023, 0.038, 0.032, respectively) in the patient older than 2 years old.Conclusion: While parental atopy and diet determine the severity of the disease in the early period of life, environmental factors have a more obvious role in later periods.
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    A Different Clinical Type of OSAS: REM-Related OSAS
    (2015) İnönü Köseoğlu, Handan; Kanbay, Asiye; Demir, Osman
    Abstract:Amaç: Uykuda hızlı göz hareketlerinin görüldüğü (Rapid Eye Movement) REM dönemi, faringeal kas aktivitesinin azalarak üst solunum yolu kollapsının belirgin arttığı, obstrüktif solunumsal olayların sıklığı ve süresinin arttığı, oksijen desatürasyonunun daha fazla görüldüğü bir dönemdir. REM ilişkili obstrüktif uyku apne sendromu (obstructive sleep apnea syndrome, OSAS), varlığı ve tanımlanması konusunda farklı görüşlerin ileri sürüldüğü, kimilerince OSAS'ın başlangıç prezentasyonu, kimile- rince farklı bir OSAS klinik tipi olarak sınıflandırılmaktadır. Bu çalışmada REM ilişkili olan ve olmayan OSAS'lı olguların, klinik ve polisomnografi (PSG) özelliklerinin karşılaştırılarak, REM ilişkili OSAS'ın farklı bir OSAS klinik tipi mi, OSAS öncüsü mü olduğu yönünde yargıya varılması amaçlanmıştır. Yöntemler: Çalışma retrospektif olarak yapıldı. Uykuda solunum bozukluğu ön tanısı ile PSG yapılan, apne-hipopne indeksi (AHİ) >= 5 tespit edilerek OSAS tanısı konu- lan olgular iki gruba ayrıldı: AHİNREM < 5 olmak üzere, AHİREM / AHİNREM >2 olan ve en az 30 dakika süreyle REM kaydı elde edilen olgular ''REM ilişkili OSAS'', bu tanıma uymayanlar ''REM ilişkili olmayan OSAS'' olarak sınıflandırıldı. Bulgular: Yaş ortalaması 51 ± 10 yıl olan 329 olgu çalışmaya alındı. Olguların 35 (%10,6)'i REM ilişkili, 294 (%89,4)'ü REM ilişkili olmayan gruptaydı. Yaş, beden kitle indeksi, sigara öyküsü, ek hastalıklar açısından gruplar benzerdi (p>0,05). REM ilişkili olgularda AHİ daha düşük, REM, NREM Evre 3 süresi daha uzun, ortalama oksijen saturasyonu daha yüksekti (p<0,05). Sonuç: Çalışmamızda grupların yaş, beden kitle indeksi, ek hastalık görülme oranının benzer tespit edilmesi; REM ilişkili OSAS'ın, OSAS'ın erken dönemi veya öncüsü olmaktan çok, farklı bir OSAS klinik tipi olduğunu düşündürmektedir.
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    The effect of periodontal treatment on depression, body image, self esteem and anxiety in individuals: A randomized controlled clinical trial
    (2021) Gokturk, Ozge; Inanir, Sema; Balci Yuce, Hatice; Demir, Osman; Aydemir Turkal, Humerya
    Aim: Depression is a multi-factorial disease characterized by a variety of symptoms. Individuals with psychiatric disorders are seem to be more prone to periodontitis. However, depression and periodontal disease can be considered bidirectional risk factors. Periodontal diseases can also be an effect on depression. The aim of this study is to determine the effect of non-surgical mechanical periodontal treatment on psychological state. Materials and Methods: Two randomized groups were established from depressed patients with non-treated periodontal diseases. Test (n = 92) and control group (n = 92). Clinical periodontal and psychological measures were administered at baseline and at 6 weeks in the control and test group. Periodontal treatment was applied to the test group. Results: After 6 weeks (the end of the periodontal therapy) there was a significant decrement in the results of Beck Depression Inventory (p a = 0.038) and a significant increment in Body Cathexis Scale (p a < 0.001) results in the test group. However, the results of Rosenberg Self-Esteem Scale (p a = 0.820) and Beck Anxiety Inventory (p a = 0.071) is similar between test and control groups. Conclusion: Within the limits of present study, the results suggest that periodontal treatment might be useful to improve depressive patients’ psychological conditions.
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    Is There a Link Between Obstructive Sleep Apnea Syndrome and Fibromyalgia Syndrome?
    (2017) İnönü Köseoğlu, Handan; İnanır, Ahmet; Kanbay, Asiye; Okan, Sevil; Demir, Osman; Çeçen, Osman; İnanır, Sema
    Abstract:OBJECTIVES: Fibromyalgia syndrome (FMS) is characterized by complaints of chronic musculoskeletal pain, fatigue, and difficulty in falling asleep. Obstructive sleep apnea syndrome (OSAS) is associated with symptoms, such as morning fatigueness and unrefreshing sleep. We aimed to investigate the presence of OSAS and objectively demonstrate changes in sleep pattern in patients with FMS. MATERIAL AND METHODS: Polysomnographic investigations were performed on 24 patients with FMS. Patients were divided into two groups: patients with and without OSAS (Group 1 and Group 2, respectively). A total of 40 patients without FMS who presented to the sleep disorders polyclinic with an initial diagnosis of OSAS were included in Group 3. Based on their apnea hypopnea index (AHI), OSAS in the patients were categorized as mild (AHI, 5-15), moderate (30), or severe (>30). RESULTS: OSAS was detected in 50% of patients with FMS. The most prominent clinical findings were morning fatigue and sleep disorder, which were similar in three groups. In polysomnography (PSG) evaluation, patients with FMS had mild (33%), moderate (25%), and severe (42%) OSAS. In correlation analyses, negative correlations were observed between fibromyalgia impact questionnaire (FIQ) and mean oxygen saturation, visual analogue scale (VAS), and minimum oxygen saturation, whereas a positive correlation was found between FIQ and desaturation times in patients with FMS. CONCLUSION: Detection of OSAS in 50% of the patients with FMS, and similar rates of complaints of sleep disorder and morning fatigue of OSAS and FMS cases are important results. Detection of correlation between the severity of hypoxemia and FIQ and VAS scores are significant because it signifies the contribution of increased tissue hypoxemia to the deterioration of clinical status. Diagnosis and treatment of OSAS associated with FMS are important because of their favorable contributions to the improvement of the clinical picture of FMS.
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    Non-invasive prediction of fibrosis in chronic hepatitis B
    (2019) Akin, Mustafa Salih; Yeniova, Abdullah Ozgur; Demir, Osman
    Aim: To date, the main diagnostic tool for assessing the liver fibrosis stage has been liver biopsy. Despite the advantages in patient prognosis prediction and disease management, the application of liver biopsy is hampered by its limitations. The limitations of liver biopsy have led to a need for the development of a non- invasive scoring system that is simple to use, reliable, and cheap. The aim of this study was to evaluate the accuracy of APRI (AST to Platelet Ratio Index) and FIB-4 (Fibrosis-4) scores in the prediction of liver fibrosis in Chronic Hepatitis B patients.Material and Methods: A retrospective assessment was made of the electronic medical records to identify patients who underwent liver biopsy for evaluation of fibrosis related to CHB (Chronic Hepatitis B). A total of 352 patients were included in the study. Laboratory parameters that were measured within 7 days of the liver biopsy day were considered suitable for the calculation of the formulae. The APRI and FIB-4 scores was calculated. Liver biopsy reports, which were eligible for inclusion in the study, were assessed retrospectively. The fibrosis stage and histological acitvity index were used as previously described by Ishak. Analyses were performed using SPSS 22 (IBM SPSS Statistics 22, SPSS inc., an IBM Co., Somers, NY).Results: APRI was well correlated with fibrosis and HAI score (r=0.280, p0.05; r=0.22, p0.05) respectively. The FIB-4 correlation between fibrosis and HAI was significant (r=0.433, p0.05; r=0.34, p0.05) respectively.Conclusion: Inexpensive, non-invasive, and reliable fibrosis assessement models for CHC should be applied in clinical practice.Keywords: Chronic hepatitis B; liver fibrosis; APRI, FIB-4.