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Öğe Antiinflammatory and antioxidant activities of different hemostatics and pulp capping materials applied on rat teeth Biochemical effects of direct pulp capping with different hemostatics(Bayrakol Medical Publisher, 2021) Saygin, Aysegul Goze; Unal, Murat; Ercan, Nazli; Demir, PinarAim: This study aimed to investigate the anti-inflammatory and antioxidant activities of different hemostatic agents and pulp capping materials. Material and Methods: Ninety-six Wistar albino mate rats were divided into the following groups: Sterile Saline (SS), Sodium Hypochlorite (NaOCl), Mecsina Hemostopper (MIAS). Occlusal cavities were prepared in the first molar teeth. Hemostatic agents were used to control bleeding and different pulp capping materials were applied on the exposed pulp area. Subgroups were created according to pulp capping materials (Dycal, Biodentine Theracal, MTA RepairHP). Half of the groups were left to wait for sacrifice on the 7th day and the others on the 28th day. Cardiac blood was taken to determine of antiinflammatory and antioxidant serum markers. Results: The use of different hemostatic agents in terms of antioxidant (CAT, GPX) and anti-inflammatory (IL1-beta, TNF-alpha, IL-6) activity was statistically significant (p <0.05). There was no statistical significance between groups for SOD (p> 0.05). IL-6 was significantly higher on the 7th day than on the 28th day (p <0.05). The and-inflammatory activity reduced from the 7th to the 28th day, in contrast, antioxidant activity induced. Discussion: The inflammation process was related to the hemostatic agents and the capping materials used in DPC treatment. MHS may be an alternative for DPC treatment for bleeding control.Öğe Biostimulatory Effects of Diode Laser and Ozone on Wound Healing in Rats(Galenos Yayincilik, 2018) Alan, Hilal; Guler, Cigdem; Yolcu, Umit; Koparal, Mahmut; Cakir, Ebru; Demir, PinarObjective: Diode laser and ozone can be used to healing of skin wounds. The aim of this study is to evaluate the biostimulatory effects of diode laser and ozone on the healing of sutured skin wounds in rats. Materials and Methods: In this study, 21 adult males Wistar albino rats were used. Three 1-cm-longs, full-thickness incisions were applied to the back of each animal and closed with sutures. Diode laser treatment, irrigation with 0.9% saline solution and ozone therapy was applied to the wounds through 7 days. Animals were euthanized on the 3rd, 7th, and 14th days after treatment, and all wounds were surgically removed for histopathological evaluation. Results: According to histological results, a statistically significant difference was found among the three treatment methods in acute inflammatory reactions on 3rd day (p<0.05). Ozone treatment reduced the intensity of acute inflammatory reactions by the 3rd day (p<0.05). In addition, a statistically significant difference was found between the follow-up periods in all treatment groups for fibrosis (p<0.01). Conclusion: It was found that ozone treatment was more effective when compared to the other treatments for reducing the intensity of acute inflammatory reactions on the healing of sutured skin wounds.Öğe Efficacy of Preemptive Analgesia on Postoperative Pain Control in Children Who Underwent Full-Mouth Dental Rehabilitation Under General Anesthesia: A Randomized Controlled Clinical Trial(Quintessence Publishing Co Inc, 2021) Keles, Sultan; Kocaturk, Ozlem; Demir, PinarAims: To evaluate the efficacy of intravenous preemptive analgesia on postoperative pain in children undergoing dental rehabilitation under general anesthesia. Methods: In this prospective randomized clinical trial, 70 children aged 3 to 7 years were scheduled for dental treatment and randomized into two groups: the control group or the preemptive group. Patients received 15 mg/kg of intravenous paracetamol either before the start of treatment (preemptive group, n = 35) or at the end of treatment (control group, n = 35). Postoperative pain scores were recorded at 1, 2, 4, 6, 8, 12, and 24 hours using the Wong-Baker FACES Pain Rating Scale (WBFS). Additionally, the need for rescue analgesic and the total opioid consumption of the patients were recorded during the first 24 hours postoperative. Results: The pain scores in the preemptive group were significantly lower than those in the control group at the postanesthesia care unit and at 2, 4, and 8 hours postoperative (P <.05). However, there were no statistically significant differences in pain scores between groups at 12 and 24 hours postoperative. Need for rescue analgesics and total intravenous fentanyl consumption were significantly higher in the control group than in the preemptive group (P <.05). The percentage of children who received medication for pain relief at home was higher in the control group than in the preemptive group, but the difference was not statistically significant (P >.05). Conclusion: Preemptive use of intravenous paracetamol reduces postoperative pain scores and postoperative opioid consumption. However, there is a need to evaluate pain levels in children who receive comprehensive dental treatment under general anesthesia after hospital discharge for effective postoperative pain control.Öğe Evaluation of Epidemiology and Etiology of Dental Injuries Observed in Children(Medicine Science, 2015) Kizilci, Esra; Demir, PinarÖz: Travmatik dental yaralanmalar (TDY); sıklığı, genç yaşlarda meydana gelmesi, hastanın ileriki hayatında tedavi ve takibinin devam etmesi ve bu nedenle maliyetin yüksek olması sebepleriyle önemli bir halk sağlığı problemidir. Son 30 yılda bilimsel literatürdeki TDY sıklığı anlamlı derecede artış göstermiştir. TDY'nin etiyolojik ve epidemiyolojik etkenlerinin bilinmesi hekime tanı ve tedavi planlamasında önemli ölçüde destek olur. Bu çalışmada amaç, 15 yaşın altındaki çocukların TDY'lerinin epidemiyolojik özelliklerini tanımlamaktır. Bu çalışmada elde edilen sonuçlar pediatrik popülasyonun bu tip yaralanmalarında tedavinin ve önleyici tedbirlerin geliştirilmesi için yararlı olacaktır Başlık (İngilizce): Çocuklarda Görülen Diş Yaralanmalarının Etiyoloji ve Epidemiyolojilerinin Değerlendirilmesi Öz (İngilizce): Traumatic dental injuries(TDI) is an important public health problem because of its frequency, occurrence at a young age and the high cost treatment follow-up procedures reason for continuing forward in the life of the patient's. In scientific literature, TDI frequency has increased in the last 30 years. Knowing the etiological and epidemiological factors of traumatic dental injuries would significantly support physicians in diagnosis and treatment planning. This observational retrospective study aimed to describe the epidemiological characteristics of traumatic dental injuries of children under the age of 15. The results obtained in this study will be useful for the development of the prevention and treatment of this type of injury of the pediatric populationÖğe Evaluation of possible associated factors for early childhood caries: are preterm birth and birth weight related?(Bmc, 2024) Selen, Merve Bilmez; Demir, Pinar; Inceoglu, FeyzaBackgroundThis study aimed to evaluate the oral and dental health of preschool children aged 12-71 months living in the Eastern Anatolia Region of Turkey, and to examine the effects of low birth weight (LBW) and preterm, early term and term birth on dental caries.Methods475 participants were included in the study. Intraoral examinations were performed and evaluated for the presence of early childhood caries (ECC). These values are; Relationships such as age, gender, birth weight, week of birth, tooth brushing frequency, cariogenic nutrition, and parental education levels were examined. The obtained data were analyzed statistically (chi-square, t-test, artificial neural network (ANN)).ResultsOf the 475 participants, whose parents agreed to fill out the questionnaire, 250 were female and 225 were male. While the mean age was 49.78 +/- 14.78 months for those with ECC, it was 38.93 +/- 17.96 months for those without. Higher duration of breastfeeding (p = 0.04), education level of parents (p = 0.001), lower socioeconomic level (p = 0.001), and lower brushing frequency (p = 0.001) were also found to be significantly associated with ECC. ECC was seen in 90% of 77 children with a history of preterm birth. In LBW, this rate was 83%. According to the ANN result, in preterm birth; 12.9% affected ECC by LBW.ConclusionAccording to the results of our study, both LBW and preterm delivery were found to be associated with ECC and S-ECC (severe early childhood caries). An additional study on parents of preterm/LBW infants would be beneficial. In the early period, regular dental examination, implementation of preventive and preventive treatments, and nutrition education to parents can make a significant difference in the prevention of ECC.Öğe Evaluation of the effectiveness of different hemostatics and bioactive materials on the success of vital pulp therapy(Bayrakol Medical Publisher, 2022) Saygin, Aysegul Goze; Unal, Murat; Candan, Merve; Demir, Pinar; Akinci, Levent; Goze, Omer FahrettinAim: The aim of this study was to evaluate the response of the pulp in combination of hemostatic agents with pulp capping materials (PCMs). Material and Methods: A total of 96 rats were used. Two molar teeth of each rat were included and all groups were created of 4 animals. In the occlusal cavities of the teeth, pulp perforations were performed for direct pulp capping. Thereafter, three different agents, which were forming the main groups [Group1: Sterile saline, Group2: Sodium hypochlorite, Group3 :Mecsina Hemostopper] at different periods of time used on pulp perforations and according to PCMs coated on the exposed pulp area, were divided into subgroups (Dycal, Biodentine, Theracal, and MTA Repair HP). Subsequently, all groups were left for two different waiting periods of 7 and 28 days. Half of the rats were sacrificed on the 7th and the remaining half were sacrificed on the 28th day, followed by micro-CT and histological analyzes. Results: When the results of the study were examined, a statistical difference was observed between groups in terms of dentine bridge (DB) formation on the 7th and 28th days, while there was no statistical difference between inflammatory cell response and DB quality. Micro-CT images showed no formation of DB on the 7th day, while DB formation was observed on the 28th day on specimens. Discussion: The combination of MHS and NaOCl may be preferable in order to provide pulp bleeding control in dental applications.Öğe Evaluation of the relationship between severe early childhood caries and vitamin D(Elsevier, 2022) Duman, Sacide; Selen, Merve Bilmez; Demir, PinarObjective: To evaluate the relationship between the factors affecting the formation of severe early childhood caries (S-ECC) in preschool children, dental caries and serum 25-hydroxyvitamin D (25(OH)D) and to contribute to the literature on this subject. Methods: ASA I-II children aged <72 months and their volunteer parents who had no apparent learning disability were included in the study. 25(OH)D, calcium and albumin levels were measured from the serum samples taken from the children. Dft, dfs and plaque scores were calculated after the oral examination of the children. Parents were asked to fill out a questionnaire assessing the child's dietary habits and family demographics. Results: Total of 175 children (56% male) participating in the study (n = 98; ECC, n = 77; caries-free). S-ECC was present in 42.8% of children with adequate 25(OH)D levels and 63.4% of children with deficient or insufficient levels. Children with S-ECC had significantly lower mean 25(OH)D levels than those caries-free. A very weak negative correlation was detected between 25(OH)D level and dft score. Conclusions: It was difficult to confirm the relationship between 25(OH)D levels and S-ECC. Again, there was a weak correlation between the dft score and 25(OH)D levels. (C) 2022 Japanese Society of Pediatric Dentistry. Published by Elsevier Ltd. All rights reserved.Öğe Knowledge and clinical experiences of pediatric dentists and endodontists regarding regenerative endodontic procedures(Bayrakol Medical Publisher, 2022) Demir, Pinar; Demircan, Beril; Bulut, Elcin Tekin; Simsek, NeslihanAim: Pediatric dentists and endodontists perform regenerative endodontic procedures (REPs) on immature permanent teeth with necrotic pulp. The aim of this survey was to gather information about the knowledge and clinical experiences of pediatric dentists and endodontists regarding REPs. Material and Methods: A 23-question survey was formed and a participation link was sent via e-mail. The questions were prepared based on AAE guide. The survey consisted of various types of questions to obtain information about the physicians' age, gender, education information, previous regenerative endodontic therapy (RET) experiences and preferred REPs clinical protocols. Results: A total of 207 volunteers, 101 pediatric dentists and 106 endodontists participated in the study. RET was chosen by 68.1% of participants as their first choice in incisors, 50.2% in premolars and 40% in molars. The most important criterion is the stage of root development (44.8%) to decide between RET or apexification; 53.5% of the participants learned about REPs during residency training; 70.5% of the participants had applied REPs before (pediatric dentists (77.2%), endodontics (64.1%)). Most of the physicians stated that a candidate suitable for RET in the future would encourage them to practice. Discussion: The majority of pediatric dentists and endodontists do not adequately follow published standard clinical protocols. However, conducting studies under standard conditions is very important in evaluating the results of clinical protocols. This is very thought-provoking that even specialist physicians who can treat patients in this regard are confused. Therefore, physicians should be informed about this issue and a common protocol should be adopted in treatments.Öğe Knowledge, Attitude and Clinical Practice of Dentists about Extraction of First Permanent Molars(Journal Pedodontics Inc, 2022) Demir, Pinar; Aydogdu, Hatice; Sari, SaziyePurpose: The extraction of permanent first molar (PFM) teeth with poor prognosis allows the build of a new-and-ideal occlusion with the spontaneous movement of the healthy second and third molars by taking advantage of the patient's development. This study aimed to evaluate dentists' knowledge level about controlled tooth extractions and determine their information needs. Study design: The survey, consisting of 9 questions about balance and compensation extractions, was prepared on Google Forms and sent via email to dentists. Results: The questionnaire was sent to 3137 dentists and 472 (15.04%) of them answered. While deciding on PFM extraction, the rate of those who checked the presence of permanent 3rd molar tooth was found to be 64.4%. Although 79% of pedodontists stated that they knew about balance extractions, only 60.9% of them apply it in the clinic. After maxillary PFM extraction, the rate of oral and maxillofacial surgeons who think that mandibular PFM over-erupt was 92.8%, and the rate of orthodontists was 68.7%. 87.1% of the participants stated that they needed more information about controlled extractions. Clinical Significance: It is possible to raise awareness, encourage the common and follow-up of correct clinical practices, and avoid complications; by adding controlled extractions to the undergraduate education program.Öğe Occurrence and Timing of Complications of Crown-Fractures in Permanent Incisors: A Randomized Clinical Trial(Assoc Apoio Pesquisa & Saude Bucal-Apesb, 2021) Demir, Pinar; Kizilci, Esra; Botsali, Murat SelimObjective: To investigate the complications of crown fractures that might occur in different follow-up periods. Material and Methods: Individuals within the 6-13 age range with crown fracture and consulted to University Hospital were included in the study. Patients were randomly divided into three groups by block randomization method and evaluated clinical and radiographically for complications at the 6, 8 weeks, and 6, 12, 24 months. The crown of the tooth was divided into 9 equal squares and 6 classes of fracture types were created. Complications and their frequencies were evaluated based on the post-traumatic substance losses in these illustrated fracture types. Results: The incidence of complications was 28.9% at 6 months, 51.3% at 1year, and 63.9% at 2years. Class4 fractures had the highest probability of complications (32.4%) and the development of pulp necrosis (40.3%). It was detected that the complications such as pulp necrosis (21.6%) can be frequently observed in the 2nd year or later periods of crown fractures. Conclusion: In addition to current regular checks, periodic follow-up of crown fracture should be extended to reflect current findings. Dentists, patients, and their parents must be made conscious of the importance of the treatment and follow-ups of crown fracture.Öğe Prevalence of Medically Compromised Children Among Dental Patients: A 10-Year Retrospective Study(Galenos Yayincilik, 2021) Demir, Pinar; Ozden, Sefika NurAim: Medical conditions can affect oral health status as well as directly affecting dental treatment planning and patient management. The purpose of this study is to evaluate the prevalence of various medical conditions of those children in a community-based dental hospital. Materials and Methods: In this study, the anamnesis forms of 30,161 children aged 0-15 who were referred to a university dental hospital from a defined geographical area in southeastern Turkey between 2010 and 2020 were evaluated. Patients who had a medical risk and chronic/ systemic/genetic diseases were included in this study. Those medical records for acute conditions, cooperation problems and isolated tooth anomalies not associated with any syndrome or genetic disease were excluded from this study. Results: 1,619 (5.36%) of the patients included in the study had at least one systemic disease. According to the medical conditions which were examined and categorized, the most common disease group was neurological disorders (17.1%) and the most common disease was epilepsy (11.7%). It was followed by Congenital/chromosomal malformations (14.8%), while autism was the most common in this group with a rate of 36.7%. Conclusion: Obtaining a detailed medical history of every patient who is referred to the dental clinic is very significant in terms of treatment planning, non-routine required protocols and complications. Dentists and pediatricians should evaluate more frequently and more rigidly, using a multidisciplinary approach, children with systemic diseases whose oral and dental health is at greater risk as a result of their medical condition.Öğe Relationship between parental adverse childhood experiences and the prevalence of early childhood caries(Springer Heidelberg, 2024) Selen, Merve Bilmez; Demir, Pinar; Eden, Ece; Inceoglu, FeyzaObjectives The aim of this study was to examine the behavioural health conditions associated with parents' retrospective adverse childhood experiences (ACEs) scores and their children's early childhood caries (ECC) in parent-child dyads. Materials and methods Parents with children younger than 72 months were included in the study. A relational screening model was used. Interaction among ACEs, ECC, nutritional habits and oral hygiene habits were evaluated. Chi-square tests and t-tests were used in the study. Multiple variables were evaluated using the artificial neural network (ANN) model. Results The mean age of the 535 children included in the study was 46.5 months, and 52% were female. Using the ANN model, there was a statistically significant relationship between the educational status of the mothers in both the ECC and severe ECC (S-ECC) groups and the socioeconomic status of the family (p < 0.05). If the number of snacks consumed daily was three or more, the risk of ECC was statistically significantly higher (chi-square test p = 0.034). The parents' ACEs scores had an impact on both ECC and S-ECC formation (p = 0.001, t-test). The higher the ACEs score, the higher the risk of S-ECC. The mean ACEs scores of the parents were also significantly higher in both the ECC and S-ECC groups compared to those of the parents of children without dental caries (p = 0.001, t-test). It was calculated that ACEs scores were effective at a rate of 18.2% on ECC (p = 0.045, ANN). Conclusions The ACEs scores of parents have an impact on the oral health of young children and ECC/S-ECC formation. Clinical relevance The long-term effects of parental ACEs are reflected in their children's oral health. Therefore, reducing the psychosocial determinants ACEs and providing parental support may help in overcoming barriers to the well-being of young children and may facilitate better oral health.
