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Öğe An analysis of ıntercultural sensitivity and ethnocentrism levels of teacher candidates(İnönü Üniversitesi Eğitim Fakültesi, 2017) Demir, Serkan; Üstün, ElifThe aim of this research is to find out the effects of two variables on primary and secondary school teacher candidates’ intercultural sensitivity and ethnocentrism levels. One of the variables is the subject matter they studied at university and the other variable is gender. The research model is descriptive. The study group consists of 314 volunteer teacher candidates who attended a private course to prepare for Public Personnel Selection Examination (aka. KPSS) during 2014-2015 academic year. Intercultural sensitivity level of teacher candidates was measured by Intercultural Sensitivity Scale developed by Chen and Starosta (2000) and their ethnocentrism level was measured by Ethnocentrism Scale developed by Neuliep and McCroskey (1997). Linguistic equivalence, validity and reliability studies of two scales were done by Ustun (2011). One way analysis of variance (ANOVA) and independent samples T test were used to analyze the data. Findings of the research showed that there is a statistically significant difference between teacher candidates’ intercultural sensitivity levels in terms of their departments at university, type of high school that they attended. Findings also showed that there is a statistically significant difference between teacher candidates’ ethnocentrism levels in terms of their departments at university.Öğe Cerebral Venous Sinus Thrombosis as a Rare Complication of Systemic Lupus Erythematosus: Subgroup Analysis of the VENOST Study(Elsevier, 2019) Duman, Taskin; Demirci, Seden; Uluduz, Derya; Kozak, Hasan Huseyin; Demir, Serkan; Misirli, Cemile Handan; Kucukoglu, HayriyeAim: Systemic lupus erythematosus (SLE) is an unusual risk factor for cerebral venous sinus thrombosis (CVST). As few CVST patients with SLE have been reported, little is known regarding its frequency as an underlying etiology, clinical characteristics, or long-term outcome. We evaluated a large cohort of CVST patients with SLE in a multicenter study of cerebral venous thrombosis, the VENOST study, and their clinical characteristics. Material and Method: Among the 1144 CVST patients in the VENOST cohort, patients diagnosed with SLE were studied. Their demographic and clinical characteristics, etiological risk factors, venous involvement status, and outcomes were recorded. Results: In total, 15 (1.31%) of 1144 CVST patients had SLE. The mean age of these patients was 39.9 +/- 12.1 years and 13 (86.7%) were female. Presenting symptoms included headache (73.3%), visual field defects (40.0%), and altered consciousness (26.7%). The main sinuses involved were the transverse (60.0%), sagittal (40.0%), and sigmoid (20.0%) sinuses. Parenchymal involvement was not seen in 73.3% of the patients. On the modified Rankin scale, 92.9% of the patients scored 0-1 at the 1-month follow-up and 90.9% scored 0-1 at the 1-year follow-up. Conclusions: SLE was found in 1.31% of the CVST patients, most frequently in young women. Headache was the most common symptom and the CVST onset was chronic in the majority of cases. The patient outcomes were favorable. CVST should be suspected in SLE patients, even in those with isolated chronic headache symptoms with or without other neurological findings.Öğe Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein(Galenos Publ House, 2024) Koc, Sumeyye; Sen, Sedat; Terzi, Yuksel; Kizilay, Ferah; Demir, Serkan; Aksoy, Durdane Bekar; Kurtulus, FatmaBackground: Optic neuritis, myelitis, and neuromyelitis optica spectrum disorder (NMOSD) have been associated with antibodies against myelin oligodendrocyte glycoprotein-immunoglobulin G (anti-MOG-IgG). Furthermore, patients with radiological and demographic features atypical for multiple sclerosis (MS) with optic neuritis and myelitis also demonstrate antibodies against aquaporin-4 and anti-MOG-IgG. However, data on the diagnosis, treatment, follow-up, and prognosis in patients with anti-MOG-IgG are limited. Aims: To evaluate the clinical, radiological, and demographic characteristics of patients with anti-MOG-IgG. Study Design: Multicenter, retrospective, observational study. Methods: Patients with blood samples demonstrating anti-MOG-IgG that had been evaluated at the Neuroimmunology laboratory at Ondokuz May & imath;s University's Faculty of Medicine were included in the study. Results: Of the 104 patients with anti-MOG-IgG, 56.7% were women and43.3% were men. Approximately 2.4% of the patients were diagnosed with MS, 15.8% with acute disseminated encephalomyelitis (ADEM), 39.4% with NMOSD, 31.3% with isolated optic neuritis, and 11.1% with isolated myelitis. Approximately 53.1% of patients with spinal involvement at clinical onset demonstrated a clinical course of NMOSD. Thereafter, 8.8% of these patients demonstrated a clinical course similar to MS and ADEM, and 28.1% demonstrated a clinical course of isolated myelitis. The response to acute attack treatment was lower and the disability was higher in patients aged > 40 years than patients aged < 40 years at clinical onset. Oligoclonal band was detected in 15.5% of the patients. Conclusion: For patients with NMOSD and without anti-NMO antibodies, the diagnosis is supported by the presence of anti-MOG-IgG. Furthermore, advanced age at clinical onset, Expanded Disability Status Scale (EDSS) score at clinical onset, spinal cord involvement, and number of attacks may be negative prognostic factors in patients with anti-MOG-IgG.Öğe Müstakilleşme sürecinde sebeb-i vürûd bilgilerinin bazı hadis ilimlerinde kullanımı(İnönü üniversitesi ilahiyat fakültesi, 2016) Demir, SerkanHadislerin söylendiği ya da yapıldığı ortam hakkındaki bilgileri tesbit etmeyi amaçlayan esbâbü vürûdi’l-hadîsin, hadis ilimleri arasında müstakil bir başlık olarak incelenmesi geç bir döneme tekabül etmektedir. Bu durumun temel nedenlerinden birisi esbâbü vürûdi’l-hadîs bilgilerinin hicrî IX. asra kadar muhtelifü’l-hadîs, nâsihu’l-hadîs ve garîbü’l hadis gibi farklı ilmî disiplinler içerisinde kullanılmasıdır. Bu makalede söz konusu durum bazı örnekler üzerinden ortaya konulmaya çalışılacaktır.Öğe The Turkish experience of COVID-19 infection in people with NMOSD and MOGAD: A milder course?(Elsevier Sci Ltd, 2022) Sen, Sedat; Tuncer, Asli; Ozakbas, Serkan; Uzunkopru, Cihat; Baba, Cavid; Demir, Serkan; Beckmann, YesimBackground: COVID-19 is a multisystemic infection with variables consequences depending on individual and comorbid conditions. The course and outcomes of COVID-19 during neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) are not clearly known. Objective/methods: The aim of this study was to examine the features and outcomes of COVID-19 infection in NMOSD and MOGAD patients. The patients' demographic and clinical factors, disease modifying treatment (DMT) used and disease information of COVID-19 infection were recorded. Conditions leading to hospitalization and severe exposure to COVID-19 infection were also analyzed. Results: The study included 63 patients from 25 centers. Thirty-two patients (50.8%) belong to AQP-4 seropositive group, 13 (20.6%) and 18 (28.6%) were in MOG-positive and double-seronegative groups, respectively. Risk factors for severe COVID-19 infection and hospitalization were advanced age, high disability level and the presence of comorbid disease. Disease severity was found to be high in double-seronegative NMOSD and low in MOGAD patients. No statistically significant effect of DMTs on disease severity and hospitalization was found. Conclusion: In NMOSD and MOGAD patients, advanced age, high disability and presence of comorbid disease pose risks for severe COVID-19 infection. There was no direct significant effect of DMTs for COVID-19 infection.
