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    Could Fetuin-A Be a Biomarker for Autism Spectrum Disorder and Cognitive Developmental Delay?
    (Maik Nauka/Interperiodica/Springer, 2022) Kurt, Nezahat; Ozgeris, Fatma B.; Ucuz, Ilknur; Bayraktutan, Zafer; Kocak Yilmaz, Kubra; Demirdogen, Esen Yildirim; Cayir, Atilla
    Early detection of cognitive developmental delay (CDD) and autism spectrum disorder (ASD) is challenging, despite the numerous scientific studies conducted and different therapeutic strategies. Lack of a biomarker for autism is a limiting factor for early diagnosis, which could provide better outcome with early start of therapy. Because of the high serum fetuin-A concentration during intrauterine life, it has been suggested that fetuin-A may have a role in brain development. The current study sought to determine if fetuin-A, a multifunctional glycoprotein thought to have a role in brain development, may be used as a biomarker for the diagnosis of ASD and developmental delay. The study involved 55 children with cognitive developmental delays and 40 healthy children. Two categories of children with cognitive developmental delays were identified. The participants were subjected to a psychiatric assessment as well as developmental testing. Only 54.5% of the 55 individuals had CDD, whereas 45.5% had ASD. Using an ELISA kit, the levels of serum fetuin-A were determined spectrophotometrically. The serum fetuin-A levels in the patients from the test group were found to be significantly lower than in the healthy individuals (p < 0.001). The cutoff value for the serum fetuin-A levels for cognitive developmental delay and autism spectrum disorder was 518 mu g/liter, according to the results of ROC analysis (84.6% sensitivity and 91.4% specificity, AUC: 0.95, p < 0.001). The findings suggest that the serum fetuin-A level may be used to diagnose autism spectrum disorder and cognitive developmental delays.
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    Could Fetuin-A Be a Biomarker for Autism Spectrum Disorder and Cognitive Developmental Delay? (vol 87, pg 559, 2022)
    (Maik Nauka/Interperiodica/Springer, 2022) Kurt, Nezahat; Ozgeris, Fatma B.; Ucuz, Ilknur; Bayraktutan, Zafer; Kocak Yilmaz, Kubra; Demirdogen, Esen Yildirim; Cayir, Atilla
    There is an incorrect Ethics committee decision number on pages 560 and 564; the correct number is B.30.2.ATA.0.01.00/69.
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    Social media addiction, escapism and coping strategies are associated with the problematic internet use of adolescents in Türkiye: a multi-center study
    (Frontiers Media Sa, 2024) Demirdogen, Esen Yildirim; Akinci, Mehmet Akif; Bozkurt, Abdullah; Bayraktutan, Busranur; Turan, Bahadir; Aydogdu, Sevil; Ucuz, Ilknur
    Introduction: The literature highlighted that problematic internet use can have detrimental consequences on individuals' well-being. Social media addiction, escapism and coping skills are closely related to problematic internet use. However, no study has currently examined the relationship between problematic internet use and social media use, escapism and coping skills. Method: This multicenter cross-sectional designed study evaluated the relationships between problematic internet use and social media addiction, escapism, and coping skills in 508 adolescents (319 female) aged 14-18 years. In order to collect data, sociodemographic data form, Internet Addiction Scale, Social Media Addiction Scale, Escapism Scale and Kidcope Adolescent Version have been used. First, adolescents who scored >= 50 on the Internet Addiction Test were classified as the problematic internet use group; adolescents who scored <50 were classified as the control group. Then, the relationships between problematic internet use and social media addiction, escapism and coping skills were evaluated. Results: The results showed that problematic internet use was associated with duration of social media use, impairment in social media-related functionality, preferring virtual life, and virtual pleasure, escapism, avoidant and negative coping strategies. Conclusion: These findings may provide an empirical basis for problematic internet use prevention and intervention in adolescence.