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    Effects of Lycium barbarum on bacterial translocation in thioacetamide-induced liver injury in rats
    (Sage Publications Inc, 2015) Bilgic, Y.; Harputluoglu, M. M. M.; Kutlu, O.; Demirel, U.; Gul, M.; Otlu, B.; Temel, I.
    Background and study aim: The aim of the present study was to investigate the effects of Lycium barbarum (LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats. Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarum was administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum. Results: In our study, Lycium barbarum treatment did not attenuate liver damage. Lycium barbarum treatment decreased ileal E. coli counts and intestinal damage but it did not alter BT frequency. Conclusions: In conclusion, the effects of Lycium barbarum on BT may be related to ongoing severe liver damage in this model.
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    The effects of Teucrium polium on ionizing radiation-induced intestinal damage in rats
    (Univ Catholique Louvain-Ucl, 2011) Demirel, U.; Harputluoglu, M. M. M.; Us, S. B.; Kaya, E.; Sahin, N.; Aydin, N. E.; Gursoy, S.
    Background and study aims : Oxidative stress plays an important role in development of intestinal injury after abdomino-pelvic radiation therapy. Teucrium poliuin (TP) is a medicinal plant which has antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effect of TP on radiation-induced intestinal oxidative damage in rats. Materials and methods : Group 1 (n = 8), the control group; Group 2 (n = 8), the RAD (radiation) group in which each rat received a single whole-body 800 cGy radiation performed with a LINAC; Group 3 (n = 8), the RAD + TP group in which rats were exposed to radiation as in Group 2, followed by intragastric administration of 0.5 g/kg/daily TP extract for 7 consecutive days; and Group 4 (n = 8), the TP group, rats received only intragastric TP for 7 days. Results : Radiation led to intestinal damage, which was accompanied by an increase in intestinal thiobarbituric-acid-reactive substances (TBARS) and myeloperoxidase (MPO) levels, and a decrease in reduced glutathione (GSH) levels. Although TP significantly decreased intestinal MPO levels and inflammation scores, it neither reverted intestinal TBARS and GSH levels nor ameliorated other histological parameters of the disease. Conclusions : Our results suggest that TP reduces inflammation but does not ameliorate the increased oxidative stress conditions in radiation-induced intestinal damage in rats. (Acta gastroenterol. belg., 2011, 74, 491-496).
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    Endoscopic treatment of biliary complications after duct-to-duct biliary anastomosis in pediatric liver transplantation
    (Springer, 2019) Harputluoglu, M.; Demirel, U.; Caliskan, A. R.; Selimoglu, A.; Bilgic, Y.; Aladag, M.; Erdogan, M. A.
    Background Studies reporting outcomes of endoscopic treatment methods in children who underwent liver transplantation (LT) is very limited. We present our outcomes, as a high-volume transplant center where endoscopic methods are preferred as the first choice in the treatment of biliary complications in children. Methods Patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) as the first treatment approach for biliary complications after LT between 2005 and 2017 were included. Clinical data included patient demographics, ERCP indications (stricture or leak), and treatment outcomes, including the need for percutaneous and surgical intervention. Results ERCP was performed in 49 patients who had a duct-to-duct anastomosis (38 living donor liver transplantation (LDLT), 11 deceased donor liver transplantation (DDLT)). The most common biliary complication was stricture. Our endoscopic success rate was 66.7% (18/27) and 75% (6/8) in LDLT and DDLT patients with stricture (p > 0.05), respectively. While our endoscopic success rate was 75% (3/4) in patients with leak alone after LDLT, it was 25% (1/4) in patients with leak and stricture in this group. The endoscopic success rate was 50% in two patients who had leak alone after DDLT. Conclusions ERCP should be considered as a preferential treatment option for the management of biliary complications in pediatric liver transplant patients with duct-to-duct anastomosis, as in adults.
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    Endoscopic treatment of biliary complications after living donor liver transplantation in a high volume transplant center in Turkey; a single-center experience
    (Univ Catholique Louvain-Ucl, 2018) Harputluoglu, M.; Aladag, M.; Demirel, U.; Bilgic, Y.; Dertli, R.; Erdogan, M. A.; Karincaoglu, M.
    Background and aim : Biliary complications are an important cause of mortality and morbidity after living donor liver transplantation (LDLT). We present our endoscopic treatment results after LDLT as a single center with high volume. Methods : Patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) alter LDLT between 2005 and 2015 were included. Clinical data included patient demographics. ERCP indications (stricture or leak), and treatment outcomes, including need for percutaneous and surgical interventions. Results : ERCP was performed in 446 (39.2%) patients with duct-to-duct anastomosis of 1136 LDLT patients. The most common biliary complication was stricture +/- stone (70.6%, 315/446). Stricture and leak occurred in 60 (13.4%) patients. Only binary leak was found in 40 (8.9%) patients. Our endoscopic treatment success rate in patients with biliary stricture after LDLT was 65.1%. Overall endoscopic success rates in our patients were 55.0% in patients with both leak and stricture, and only leak. In all, our percutaneous transhepatic biliary interventions (P'f BI) and ERCP success rate was 90.6% in patients with biliary complications after LDLT. Conclusions : Endoscopic treatments are highly effective for biliary complications after LDLT. Effective use of percutaneous interventions in collaboration with endoscopic treatments significantly reduces the need for surgical treatment.
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    Endoscopic treatment of biliary complications after pediatric liver transplantation in a high volume transplant center in Turkey
    (Lippincott Williams & Wilkins, 2018) Harputluoglu, M. M. M.; Aladag, M.; Bilgic, Y.; Erdogan, M. A.; Caliskan, A. R.; Selimoglu, A.; Demirel, U.
    [Abstract Not Available]
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    Relationship between nucleotide-binding oligomerization domain-containing protein 2 variants and severity of acute pancreatitis
    (Univ Catholique Louvain-Ucl, 2019) Harputluoglu, M. M. M.; Ozbek, M.; Demirel, U.; Otlu, B.; Yener, O.; Gursoy, N. C.; Tikici, D.
    Background and aim : Intestinal bat tier dysfunction has been implicated in the development of infectious complications of acute pancreatitis. Nucleotide-Binding Oligomerization Domain- Containing Protein 2 (NOD2) plays an important role in the proper functioning of intestinal defense mechanisms. Here, we investigated the frequency of NOD2 variants in patients with mild and severe acute pancreatitis. Materials and Methods : Groups 1, 2 and 3 comprised healthy participants and patients with mild and severe pancreatitis, respectively. Four NOD2 variants and serum interleukin-6 (IL-6), Tumor Necrosis Factor-a (TNF-a) and lipopolysaccharide-binding protein (LBP) levels were analyzed. Results: Three patients (3/32, 9.4%) in the severe pancreatitis group were positive for the p.R702W valiant. This valiant was negative in other groups. One, three and three patients in the healthy (1/27,3.7%), mild (3/36,8.3%) and severe pancreatitis (3/32, 9.4%) groups tested positive for the 1007fs variant, respectively. No significant difkrences in the frequencies of NOD2 variants were evident among the groups. Serum IL-6, TNF-a and IMP levels were markedly higher in the severe pancreatitis than the healthy and mild pancreatitis groups (all p<0.091). We observed no significant correlation between cytokine levels and NOD2 variants. Conclusion : Our results support an association between the presence of the p.R702W variant and severe pancreatitis.