Yazar "Demirelli, Erhan" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim
    Öğe
    Diagnostic performance of prostate imaging reporting and data system v2.1: Single center experience
    (2019) Bekci, Tumay; Oguz, Ural; Tosun, Alptekin; Demirelli, Erhan; Ogreden, Ercan; Sengul, Demet
    Aim: To assess the diagnostic accuracy of PI-RADS v2.1 using multi-parametric magnetic resonance imaging (mpMRI) to detect prostate cancer (pCa) and comparison with transrectal biopsy/radical prostatectomy results.Material and Methods: Between June 2017 and April 2019, 124 patients who underwent mpMRI prior to transrectal biopsy/ radical prostatectomy were evaluated by a pathology results-blinded uroradiologist using PI-RADS v2.1 categories, retrospectively. PIRADS v2.1 category results were compared with transrectal biopsy/radical prostatectomy results. All clinical data were used in statistical analysis.Results: The sensitivity, specificity, positive predictive value, negative predictive value and accuracy values of mpMRI using PI-RADS v2.1 categorization were 96%, 44%, 73%, 88% and 75%, respectively. A significant correlation was observed between a high PI-RADS score and high pathological grade (p0.001). The inter observer agreement expressed as the ICC was 0.65 (95% CI: 0.33–0.84, p 0.001).Conclusions: The mpMRI, used in conjunction with PI-RADS v2.1, is a useful and promising imaging method in detection of pCa. Keywords: Prostate cancer; multiparametric MRI; PI-RADS; transrectal biopsy; radical prostatectomy.
  • Küçük Resim
    Öğe
    Does dutasteride have any cardioprotective effect in elderly men? A prospective randomised controled study
    (2019) Oguz, Ural; Karagoz, Ahmet; Tosun, Alptekin; Demirelli, Erhan; Usta, Murat; Ogreden, Ercan; Karagoz, Emel; Karadayi, Mehmet; Koseoglu, Mehmet Hicri; Baser, Bengi; Yalcin, Orhan
    Aim: To investigate whether the increased serum levels of testosterone secondary to Dutasteride therapy has any protective effect on cardiovascular system.Material and Methods: A prospective analysis of 50 patients diagnosed benign prostatic enlargement between May 2015 and May 2017 was performed. After randomization 25 patients treated with daily administration of 0.5 mg dutasteride (Dutasteride Group), and 25 patients were not given dutasteride (Control Group). We analyzed some serum novel cardiaovascular marker levels at baseline and after 6 months of the treatment. Echocardiography, carotid intima-media thickness and brachial artery resistive index (RI) were evaluated at baseline and after 6 months of the treatment.Statistical analyses were performed using SPSS, version 21. While “t test” was used for comparison the independent groups, paired t test was used in the matched groups. Statistical significance was considered at p0.05.Results: The differences in serum Lp a, hs-CRP and NT-proBNP levels were not statistically significant (p>0.05). Additionally, echocardiographic parameters, carotid intima-media thickness and brachial artery RI were similar before and after dutasteride tratment. Conclusion: After the short-term use of dutasteride, there was not a statistically significant difference in serum Lp a, hs-CRP and NT-proBNP levels. Additionally, echocardiographic parameters, carotid intima-media thickness and brachial artery RI were also similar.
  • Küçük Resim Yok
    Öğe
    Effects of Tadalafi l on Macular Parameters and Choroidal Thickness in Diabetic Patients
    (Retina-Vitreus, 2018) Özer, Murat Atabey; Özen, Serkan; Polat, Nihat; Öğreden, Ercan; Demirelli, Erhan; Beytur, Ali; Küçüksümer, Yaşar
    Öz: Objective: To investigate the effects of tadalafi l on macular parameters and choroidal thickness in diabetic patients with erectile dysfunction (ED). Materials and methods: Total 37 diabetic patients with ED were included in this single-centred, open-label prospective study. The treatment was initiated with 5 mg tadalafi l hydrochloride daily for 3 months. Choroidal thickness, central macular thickness (CMT), and total macular volume (TMV) measurements were performed using spectral domain optical coherence tomography (SD-OCT). SD-OCT and visual acuity (VA) measurements were repeated during all visits. Fundus fl uorescein angiography (FFA) was also performed at baseline and at the 12 th week. Results: There was a statistically signifi cant increase in the choroidal thickness compared to that at baseline at all visits except at the fi rst visit (mean central foveal choroidal thickness, baseline; 248.7 ± 21.5, 1 st day; 247.4 ± 23.2, 4 th week; 275.9 ± 21.3, and 12 th week; 275.1 ± 24.4, ?m, p < 0.001). There was no statistically signifi cant change in the mean VA (baseline; 0.21 ± 0.07, 12 th week; 0.22 ± 0.06, logMar), mean CMT (baseline; 236.7 ± 32.4, 12 th week; 234.8 ± 32.8, ?m), mean TMV (baseline; 9.88 ± 1.21, 12 th week; 9.83 ± 1.26, mm 3 ), and FFA compared to the baseline values (p > 0.05). Conclusions: Choroidal thickness safely increases in response to systemic tadalafi l administration. The long-term use of systemic tadalafi l does not cause any adverse effects on the retina and the macula in diabetic patients with ED.