Yazar "Demirkol, Mehmet" seçeneğine göre listele

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    Biochemical changes induced by grape seed extract and low level laser therapy administration during intraoral wound healing in rat liver: an experimental and in silico study
    (Taylor & Francis Inc, 2018) Erdemli, Mehmet Erman; Salmas, Ramin Ekhteiari; Durdagi, Serdar; Akgul, Hasan; Demirkol, Mehmet; Aksungur, Zeynep; Selamoglu, Zeliha
    In the present study, the changes that occur in rat liver tissue as a result of the use of grape seed extract (GSE) and low level laser therapy (LLLT) in intraoral wound (IW) healing are analyzed using biochemical parameters. Diode laser application groups received 8J/cm(2) dose LLLT once a day for 4days (810nm wavelength, continuous mode, 0.25W, 9s). As a result of the biological parameter analysis, it was determined that the oxidative damage caused by the IWs and recovery period on 7th and 14th days could be substantially removed with GSE applications that have antioxidant capacity especially in rat liver tissue. In addition, the active compound of grape seed, catechin is studied in the active site of glycogen synthase kinase 3 (GSK3) target using molecular modeling approaches. Post-processing molecular dynamics (MD) results for catechin is compared with a standard GSK3 inhibitor. MD simulations assisted for better understanding of inhibition mechanism and the crucial amino acids contributing in the ligand binding. These results along with a through free energy analysis of ligands using sophisticated simulations methods are quite striking and it suggests a greater future role for simulation in deciphering complex patterns of molecular mechanism in combination with methods for understanding drug-receptor interactions.
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    Clinical and radiographic features of odontogenic keratocysts and evaluation of recurrence rates after treatment: A retrospective study
    (2019) Ege, Bilal; Demirkol, Mehmet; Yalçın, Mustafa; Alan, Hilal
    Abstract: Aim: In this retrospective study, it was aimed to evaluate the clinical and pathological features of cases diagnosed with OKC and therecurrence status after treatment options.Material and Methods: 41 patients who were treated with the diagnosis of OKC between December 2015-June 2018 and whose preandpost-treatment follow-up data could be reached were included in the study. As the variables examined, age and gender of thepatients, localization of cyst and radiographic features, histopathological findings, treatment methods and recurrence status wereinvestigated retrospectively.Results: Of 41 patients with a mean age of 36.68±17.89 (age range 13 to 78) years, 24 (58.5%) were males and 17 (41.5%) werefemales. It was determined that OKCs were observed most frequently in the third decades (21.9%) followed by the second andfourth decades (19.5%). The incidence of OKC was determined to be higher in the mandible (80.5%) than in the maxilla (19.5%).The recurrence was observed in 7 of 41 cases (17.1%) after the treatment. The recurrence was detected particularly in mandibularposterior and larger lesions. The fact that five of the seven recurrent cases were parakeratotic and likewise five cases were treatedwith enucleation was noteworthy.Conclusions: The treatment and prognosis of OKC should be determined according to the condition of the case and the treatmentprotocol should be managed accordingly.
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    A retrospective analysis of anterior single dental implants
    (2019) Demirkol, Nermin; Demirkol, Mehmet
    Aim: This retrospective study aimed to examine the demographic data of patients who underwent an intraosseous maxillary anterior single dental implant and the characteristic features of dental implants, including diameter/length, distribution of anatomic localization and implant failure.Material and Methods: Demographic data, including the distribution of dental implants according to age, gender and the age of 108 patients who underwent dental implant placement in the researchers’ clinic between 2009 and 2015 were obtained from archival records. Only patients with the loss of a single tooth in the anterior region of the jaws were included. Anatomic localizations, diameter/height characteristics and implant failure results of the dental implants were analyzed with descriptive statistical analysis. Results: Of 108 patients, 47 (36.7%) were males and 61 (63.3%) were females. A total of 120 dental implants were evaluated. The mean age of the patients was 35.4±15.63 years, ranging from 18 to 70 years. The ages of the second decade, particularly 18 or 19 years old, was the most placed dental implant (n=24, 25%). A total of 103 (85.8%) implants were surgically placed into the maxillary anterior region and 17 (14.2%) into the lower jaw. The most common implant diameter was 4.1 mm (17 patients, 14.1%) and the length was 14 mm (42 patients, 35%).Conclusion: This study showed that the dental implant treatment in the esthetic region was demanded immediately by the patients without any further bone resorption.Keywords: Dental implant; mandible; maxilla; esthetic zone.
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    Upward Migration of an Asymptomatic Lower Second Molar to the Coronoid Process
    (Lippincott Williams & Wilkins, 2016) Keskinruzgar, Aydin; Demirkol, Mehmet; Dedeoglu, Numan
    [Abstract Not Available]
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    XVIII. yüzyılın ilk yarısında manastır
    (İnönü Üniversitesi, 2021) Demirkol, Mehmet
    XVIII. Yüzyılın İlk Yarısında Manastır başlıklı bu çalışma, belirlenen zaman diliminde Manastır kazasının fizikî, idarî, iktisadî, demografi ve içtimaî yapısını başta kadı sicilleri olmak üzere arşiv belgeleri ışığında ele alarak bir bütün halinde ortaya koymayı amaçlamaktadır. Konunun gereği olarak genel mahiyette Osmanlı tarihi ile ilgili bilgilere de yer verilmiştir. Yapılan çalışmanın alana katkı sağlayacağı düşünülmektedir. Araştırmamızda şehrin konumu, coğrafî özellikleri ve ulaşım imkânlarıyla ele alınmıştır. Ayrıca şehirdeki dinî, kültürel, sosyal yapılar ve ticari alanları belirtilerek şehrin fizikî yapısını oluşturan unsurlar hakkında bilgiler vererek dönemin umumi manzarası tespit edilmeye çalışılmıştır. Şehrin köyleriyle birlikte tahmini nüfusu tespit edilmiş ve nüfusu oluşturan dini ve etnik guruplar belirtilmiştir. Şehrin, Osmanlı Devleti taşra idarî taksimatı içinde Paşa sancağı olması sebebiyle eyalet valilerinin sorumluluğunda idare edilmesi bir hususiyet arz etmektedir. Bu vaziyetin etkileri şehrin ulema ve ümera kesimi üzerinde görüldüğü gibi eyaletin asayiş düzeninin sorunları da şehir bürokrasisine yansımıştır. Şehrin ticarî ve iktisadî vaziyeti bulunduğu konum itibariyle XVIII. Yüzyılın ilk yarısında da canlılığını devam ettirmektedir. Süreç içerisinde ticarî faaliyetler hakkında bilgiler verilmiş, fiyatlar ve ücretler konusuna da açıklık getirilmeye çalışılmıştır. Bütün bu hususlar üzerinde belirleyici olan ve bu hususlardan etkilenen sosyal yaşantı etraflıca ele alınmıştır. Özellikle dönemin sosyal-siyasî olayları şehrin sosyal yapısı üzerinde etki etmiş ve Manastır'ın dâhil olduğu Rumeli bölgesinin asayiş sorunları da çalışmamızda ele alınmıştır. Çalışmada, Manastır şehrinin XVIII. Yüzyılın ilk yarısındaki, genel durumu belgelerin imkân verdiği nispette ortaya konulmuştur.