Yazar "Demiroz Tasolar, Sevgi" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Microstructural White Matter Alterations in Pediatric Idiopathic Intracranial Hypertension: A Diffusion Tensor Imaging Study
    (Mdpi, 2025) Ozgor, Bilge; Ayvaz, Huseyin; Tan, Mahir; Demiroz Tasolar, Sevgi; Yucel, Gul; Bicakcioglu, Isinsu; Gungor, Serdal
    Highlights What are the main findings? Fractional anisotropy values in the optic radiation and posterior limb of the internal capsule were significantly reduced in pediatric idiopathic intracranial hypertension, indicating microstructural white matter alterations detectable by diffusion tensor imaging. DTI metrics-particularly FA-demonstrated strong discriminative accuracy (AUC = 0.83) for distinguishing affected patients from healthy controls, outperforming conventional MRI markers. What are the implications of the main findings? DTI may serve as a complementary tool to conventional MRI in the diagnostic evaluation of pediatric IIH, providing quantitative insights into pressure-related white matter changes. These findings suggest that advanced diffusion imaging could aid early detection and monitoring of intracranial pressure-related alterations, warranting validation in larger, prospective pediatric cohorts.Highlights What are the main findings? Fractional anisotropy values in the optic radiation and posterior limb of the internal capsule were significantly reduced in pediatric idiopathic intracranial hypertension, indicating microstructural white matter alterations detectable by diffusion tensor imaging. DTI metrics-particularly FA-demonstrated strong discriminative accuracy (AUC = 0.83) for distinguishing affected patients from healthy controls, outperforming conventional MRI markers. What are the implications of the main findings? DTI may serve as a complementary tool to conventional MRI in the diagnostic evaluation of pediatric IIH, providing quantitative insights into pressure-related white matter changes. These findings suggest that advanced diffusion imaging could aid early detection and monitoring of intracranial pressure-related alterations, warranting validation in larger, prospective pediatric cohorts.Abstract Background/Objectives: Idiopathic intracranial hypertension (IIH) is an uncommon but clinically important cause of elevated intracranial pressure in children. Conventional MRI findings such as perioptic subarachnoid space (SAS) distension and posterior globe flattening are helpful but may lack sensitivity or specificity in certain cases. Diffusion tensor imaging (DTI), which quantifies white matter microstructure through metrics such as fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), offers additional diagnostic potential, yet its role in pediatric IIH remains insufficiently defined. Methods: This retrospective case-control study included 26 pediatric patients with IIH and 26 age- and sex-matched controls who underwent brain MRI with DTI between 2010 and 2025. DTI parameters were measured in major white matter tracts, and conventional MRI findings associated with raised intracranial pressure were recorded. Associations between DTI metrics and conventional imaging markers were analyzed using standardized statistical tests. Results: Children with IIH demonstrated significantly reduced FA and increased MD and RD values in several key white matter regions, particularly within the optic radiation, splenium of the corpus callosum, and posterior limb of the internal capsule. FA values showed a negative correlation with perioptic SAS width, while RD and MD were positively correlated with posterior globe flattening and empty sella grade. Receiver operating characteristic analysis identified FA in the optic radiation as the strongest discriminator between IIH and controls (AUC = 0.83). Inter-observer reliability for FA measurements was excellent (ICC = 0.91). Conclusions: Pediatric IIH appears to be associated with pressure-related microstructural alterations in white matter, detectable through DTI. Among the diffusion metrics, FA demonstrated the strongest diagnostic potential and may serve as a complementary tool to conventional MRI. Validation in larger, prospective pediatric cohorts is required to establish its clinical utility.
  • Küçük Resim
    Öğe
    Türkiye’de Vergilendirmede Dijital Dönüşüm
    (2022) Demiroz Tasolar, Sevgi; Sigirci, Ahmet; Dogan, Gulec Mert; Cengiz, Aslinur; Subasi, Vedat; Yildiz, Turan; Tabel, Yilmaz
    Aim: It is aimed to evaluate the effect of reflux time in primary VUR in terms of predicting endoscopic treatment success and treatment timing in VUR management. Vesicoureteral reflux (VUR) is an important cause of urinary tract infection and chronic renal disease. Voiding cystourethrography (VCUG) is the gold standard diagnostic test in the diagnosis of VUR. In recent years, new parameters related to VCUG have been more objectively studied to evaluate the clinical prognosis. Materials and Methods: In our study, the records and imaging findings of children with primary VUR who underwent VCUG examination between 2012 and 2019, who were treated with endoscopic injections, were retrospectively reviewed. Forty-one children (67 renal units) were included in our study. Patients with preoperative VCUG, urinary ultrasonography, dimercaptosuccinic acid (DMSA) renal scan, and post-operative control VCUG were included in this study. Results: Patients with preoperative VUR grade 1-2 were divided into two groups as “low grade” and patients with stage 3-4-5 as “high grade”. In the general patient pop- ulation, endoscopic success rates in terms of renal unit deficit were found to be 46.3% (31/67). When the subgroup was analyzed, the endoscopic treatment success rate was 72.2% (13/18) in the low-grade group, versus 36.7% (18/49) in the high-grade group (p = 0.010). In the multivariate logistic regression analysis performed to identify indepen- dent predictors of scarring, reflux degree and reflux time were found to be independent predictors of scarring. Conclusion: In our study, we found that in VCUG evaluated preoperatively, VUR time as well as VUR grade were effective on endoscopic success rate and scar development. Based on these results, it could be thought that VUR time may be effective in selecting the best candidates for surgery and in the management and timing of treatment of VUR patients.