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    ADULT MINIMAL CHANGE DISEASE IN TURKEY: THE RESULTS OF TURKISH SOCIETY OF NEPHROLOGY GLOMERULAR DISEASES WORKING GROUP
    (Oxford Univ Press, 2020) Yilmaz, Murvet; Sipahioglu, Murat; Dervisoglu, Erkan; Aydemir, Nihal; Uzun, Sami; Istemihan, Zulal; Unsai, Oktay
    [Abstract Not Available]
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    Demographic, clinical and laboratory characteristics of adult-onset minimal change disease in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group
    (Springer, 2023) Aydin, Zeki; Yilmaz, Murvet; Sipahioglu, Murat; Dervisoglu, Erkan; Aydemir, Nihal; Uzun, Sami; Istemihan, Zulal
    Purpose In our study, diagnostic and demographic characteristics of patients diagnosed with minimal change disease (MCD) by biopsy, clinical and laboratory findings in our country were investigated. Methods Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. The data presented are cross-sectional and includes application data for the biopsy period. Results Of 3875 patients, 233 patients with MCD (median age 35.0 years) were included in the study, which constitutes 6.0% of the total glomerulonephritis database. Renal biopsy was performed in 196 (84.1%) patients due to nephrotic syndrome. Median serum creatinine was 0.7 (0.6-1.0) mg/dl, mean eGFR was 104 +/- 33 ml/min/1.73 m(2) and median proteinuria 6000 mg/day. The number of patients under the age of 40 years was 139 (59.7%) (Group A), and the number of patients aged 40 years and over was 94 (40.3%) (Group B). Compared to Group A, global sclerotic glomeruli (24 vs. 43, p < 0.001) interstitial inflammation (15 vs. 34, p < 0.001), interstitial fibrosis (20 vs. 31, p = 0.001, vascular changes (10 vs. 25, p < 0.001) and tubular atrophy (18 vs. 30, p < 0.001) were found to be significantly higher in Group B. There was no difference in immunofluorescent staining properties between the two groups. Conclusion Our data are generally compatible with the literature. Chronic histopathological changes were more common in patients aged 40 years and older than younger patients. Studies investigating the effects of these different features on renal survival are needed.
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    Quality of sleep in kidney transplant recipients: Any relationship with quality of life?
    (2020) Ozer, Rukiye; Eren, Necmi; Ergul, Metin; Gokcay Bek, Sibel; Dervisoglu, Erkan
    Aim: The aim of this study is to evaluate the relationship between quality of sleep (QoS) and demographic, clinical, and psychosocial factors in kidney transplant recipients. Materials and Methods: We examined sixty-four kidney transplant recipients (26 female, 38 male). Clinical, demographic, and biochemical parameters were analyzed. The QoS was evaluated using Pittsburgh Sleep Quality Index (PSQI), health-related quality of life (HRQoL) with SF-36 Health Survey and depressive symptoms with Beck’s Depression Inventory (BDI). Results: A comparison of good and poor QoS (PSQI ≤ 5, PSQI > 5, respectively) groups showed a significant difference only in BDI scores (p 0.001). There was no statistically significant difference regarding urea, creatinine, ferritin, albumin, and other laboratory parameters. Thirty-six of the 46 patients (80%) in the good QoS group were married, while 10 of 19 patients (52%) in the poor QoS group were single. Married individuals had significantly better QoS (p=0.026). A comparison of the domains of the HRQoL survey showed significantly better “physical function” in those with good QoS than those with poor QoS (51 ± 6 and 47 ± 8, respectively; p 0.017). Conclusion: Patients with poor QoS had worse HRQoL. Routine screening of depressive symptoms, which may be manageable is required for improving QoS and HRQoL in these patients.