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Öğe The effect of feeding with own mother’s milk on bronchopulmonary dysplasia in very low birth weight infants(2019) Gokce, Ismail Kursad; Deveci, Mehmet FatihAim: This study aimed to evaluate the effect of feeding with own mother’s milk on the incidence of bronchopulmonary dysplasia (BPD) and other preterm morbidities in very low birth weight (VLBW) infants.Materials and Methods: VLBW infants followed in our unit were divided into three groups according to their predominantly feeding type such as own mother’s milk group (MM), preterm formula group (PF) and mix fed group (MxF) in the first postnatal month. Groups were compared regarding demographic and clinical features including BDP. Results: The mean birth week of 117 VLBW infants was 29.3 ± 2.1 weeks and the mean birth weight was 1115 ± 265 g. Seventy seven infants were in the MM group, 17 infants were in the PF group and 23 infants were in the MxF group. There was a significant decrease in BPD incidence in the MM group compared to infants in the PM group (p=0.03). The frequency of necrotizing enterocolitis, late-onset sepsis and severe intraventricular hemorrhage (IVH) were found to decrease in the MM group when compared with other infants.Conclusion: The incidence of BPD decreases in VLBW infants fed with their own mother’s milk compared to VLBW infants fed with formula. Also besides feeding with mother’s milk may contribute to a decrease in the frequency of severe IVH.Keywords: Breastfeeding; bronchopulmonary dysplasia; intracranial hemorrhages; mother’s milk; newbornÖğe The effect of feeding with own mother’s milk on bronchopulmonary dysplasia in very low birth weight infants(2019) Gökçe, İsmail Kürşad; Deveci, Mehmet FatihAbstract: Aim: The aim was to evaluate to investigate the attitudes and behaviors of mothers who provide toilet training to their children. Material and Methods: A qualitative study was conducted with focus group interviews. This study was conducted with 24 mothers who provided toilet training to their healthy children between May and July 2017. Three focus group interviews were conducted within the scope of the study. Each group consisted of eight mothers. Semi-structured questions were used in focus interviews. These questions include “How did you know your child is ready for toilet training?”, “Are there any special practices you have done to make your child feel more comfortable with the toilet? Can you explain?” Voice recording was performed during the interviews. The data collected with voice recordings were evaluated by content analysis method, and then the main themes and sub themes of the study were formed. Results: It was determined that 45.8% of the mothers were aged between 28 and 31, 33.3% of them were primary school graduate, 50% of the children to whom toilet training was given, were determined to be aged between 2, 5 and 3. Three main themes and seven sub-themes were identified in this study. These include: 1-Decision time (behaviors of the child, age of the child, effect of family elders), 2-Facilitation activities (forming a suitable environment, encouraging) and 3-Reaction of the mother in interim incontinence(unresponsiveness, negative reaction). Conclusion: The majority of the mothers started toilet training according to the child’s age and readiness signs, used facilitation activities and generally did not react harshly to incontinence.Öğe Effect of partially hydrolyzed synbiotic formula milk on weight gain of late preterm and term infants-a multicenter study(Frontiers Media Sa, 2023) Sahin, Suzan; Buyuktiryaki, Mehmet; Okur, Nilufer; Akcan, Abdullah Baris; Deveci, Mehmet Fatih; Yurttutan, Sadik; Gunes, SezginIntroduction: Data on the effectiveness of hydrolyzed infant formula containing both pre- and probiotics (synbiotic formula) on the growth of infants is still scarce. This retrospective study was designed to evaluate the effect of a partially hydrolyzed synbiotic formula on growth parameters and the possible occurrence of major gastrointestinal adverse events or morbidities in infants born via cesarean section (C-section) delivery.Methods: C-section-delivered term and late preterm infants who received either partially hydrolyzed synbiotic formula, standard formula, or maternal milk and followed at seven different hospitals from five different regions of Turkey, during a 1-year period with a minimum follow-up duration of 3 months were evaluated retrospectively. All the included infants were evaluated for their growth patterns and any kind of morbidity such as diarrhea, constipation, vomiting, infection, or history of hospitalization.Results: A total of 198 infants (73 in the human milk group, 61 in the standard formula group, and 64 in the partially hydrolyzed synbiotic formula group) reached the final analysis. The groups were similar regarding their demographic and perinatal characteristics. No difference was observed between the three groups regarding gastrointestinal major side effects. Growth velocities of the infants in the human milk and partially hydrolyzed synbiotic formula groups during the first month of life were similar whereas the weight gain of infants in the standard formula group was significantly less than these two groups (p < 0.001). Growth velocities were similar among the three groups between 1st and 3rd months of age.Discussion: A partially hydrolyzed synbiotic formula provided better weight gain in late-preterm and term infants who were delivered via C-section delivery compared to the standard formula during the first month of life. This weight gain was similar to the infants receiving exclusively human milk. This difference was not observed in length and head circumference gain. No difference was observed in any of the parameters during the 1st-3rd months of age. Specially formulated partially hydrolyzed synbiotic formulas may reverse at least some of the negative impacts of C-section delivery on the infant and help to provide better growth, especially during the early periods of life.Öğe Evaluation of Patients with Ichthyosis Followed in a Neonatal Intensive Care Unit: A Single Center Experience(Erciyes Univ Sch Medicine, 2023) Deveci, Mehmet Fatih; Ates, Kubra; Alagoz, Meral; Tekedereli, Ibrahim; Gokce, Ismail Kursad; Aslan, Mehmet; Ozdemir, RamazanObjective: Ichthyosis is a keratinization disorder that is characterized by a defective skin barrier and inability to retain water in the skin. Ichthyosis is extremely rare and mostly hereditary, and its manifestations typically involve dryness, scaling, and hyperkeratosis. Moreover, different clinical findings may be observed depending on the concomitant anomalies. Patients with ichthyosis should be protected from infection and hypernatremic dehydration during the neonatal period. After diagnosis, patients with ichthyosis should be screened for concomitant genetic disorders and their families should be referred to genetic counseling. Materials and Methods: In this study, ichthyosis cases observed in our neonatal intensive care unit were retrospectively evaluated. We analyzed the genetic analyses and demographic and clinical data of patients hospitalized in our unit over the past 9 years. Results: Three of the 24 patients evaluated expired during the neonatal period. Genetic analysis was performed on 10 patients, with 8 exhibiting a pathogenic variant. Four of these cases were diagnosed with syndromic ichthyosis, whereas four were nonsyndromic. Conclusion: Patients with ichthyosis need to be diagnosed early and subsequently screened for accompanying anomalies. In managing this disorder, genetic analysis and counseling are as important as proper skin care, hydration, and infection prevention and should not be overlooked.Öğe Extensively drug-resistant acinetobacter baumannii meningitis which successfully treated with tigecycline; a case report of preterm newborn(2021) Deveci, Mehmet Fatih; Gokce, Ismail Kursad; Kaya, Huseyin; Ozdemir, RamazanAcinetobacter baumannii (A. baumannii) meningitis is a state difficult to treat with a high mortality rate, since antibiotics have low CSF penetration level and antibiotic resistance is frequently encountered. Multidrug-resistance is common in hospital-acquired A. baumannii infections, and in these cases, colistin treatment is frequently used as the last option. Colistin-resistant A. baumannii infections are reported in recent years. We present a case of preterm newborn who developed extensively drug-resistant (carbapenem and colistin resistance) A. baumannii meningitis after ventriculoperitoneal shunt operation. Although not approved in children, combined intravenous treatment including tigecycline, meropenem and colistin provides clinical and bacteriological recovery in colistin and carbapenem-resistant A. baumannii meningitis.Öğe Extensively drug-resistant acinetobacter baumannii meningitis which successfully treated with tigecycline; a case report of preterm newborn(2021) Deveci, Mehmet Fatih; Gokce, Ismail Kursad; Kaya, Huseyin; Ozdemir, RamazanAcinetobacter baumannii (A. baumannii) meningitis is a state difficult to treat with a high mortality rate, since antibiotics have low CSF penetration level and antibiotic resistance is frequently encountered. Multidrug-resistance is common in hospital-acquired A. baumannii infections, and in these cases, colistin treatment is frequently used as the last option. Colistin-resistant A. baumannii infections are reported in recent years. We present a case of preterm newborn who developed extensively drug-resistant (carbapenem and colistin resistance) A. baumannii meningitis after ventriculoperitoneal shunt operation. Although not approved in children, combined intravenous treatment including tigecycline, meropenem and colistin provides clinical and bacteriological recovery in colistin and carbapenem-resistant A. baumannii meningitisÖğe Molsidomine decreases hyperoxia-induced lung injury in neonatal rats(Springernature, 2023) Aslan, Mehmet; Gokce, Ismail Kursat; Turgut, Hatice; Tekin, Suat; Taslidere, Asli Cetin; Deveci, Mehmet Fatih; Kaya, HuseyinBackgroundThe study's objective is to evaluate if Molsidomine (MOL), an anti-oxidant, anti-inflammatory, and anti-apoptotic drug, is effective in treating hyperoxic lung injury (HLI).MethodsThe study consisted of four groups of neonatal rats characterized as the Control, Control+MOL, HLI, HLI + MOL groups. Near the end of the study, the lung tissue of the rats were evaluated with respect to apoptosis, histopathological damage, anti-oxidant and oxidant capacity as well as degree of inflammation.ResultsCompared to the HLI group, malondialdehyde and total oxidant status levels in lung tissue were notably reduced in the HLI + MOL group. Furthermore, mean superoxide dismutase, glutathione peroxidase, and glutathione activities/levels in lung tissue were significantly higher in the HLI + MOL group as compared to the HLI group. Tumor necrosis factor-alpha and interleukin-1 beta elevations associated with hyperoxia were significantly reduced following MOL treatment. Median histopathological damage and mean alveolar macrophage numbers were found to be higher in the HLI and HLI + MOL groups when compared to the Control and Control+MOL groups. Both values were increased in the HLI group when compared to the HLI + MOL group.ConclusionsOur research is the first to demonstrate that bronchopulmonary dysplasia may be prevented through the protective characteristics of MOL, an anti-inflammatory, anti-oxidant, and anti-apoptotic drug.ImpactMolsidomine prophylaxis significantly decreased the level of oxidative stress markers.Molsidomine administration restored the activities of antioxidant enzymes.Molsidomine prophylaxis significantly reduced the levels of inflammatory cytokines.Molsidomine may provide a new and promising therapy for BPD in the future.Molsidomine prophylaxis decreased lung damage and macrophage infiltration in the tissue.Öğe Mortality related factors on hypoxic ischemic encephalopathic patients treated with therapeutic hypothermia: an 11-year single-center experience.(2022) Deveci, Mehmet Fatih; Turgut, Hatice; Alagöz, Meral; Kaya, Hüseyin; Gökçe, İsmail Kürşad; Özdemir, RamazanBackground/aim: Hypoxic-ischemic encephalopathy (HIE) is a condition that may cause multiple organ dysfunction and has a high rate of mortality and morbidity. Therapeutic hypothermia is the only proven treatment that decreases the sequel and mortality rate of neonates that are born after 36 weeks of pregnancy and have moderate-severe HIE. Material and method: Our study was a single-center, retrospective study that includes newborns (gestational age ? 36 weeks) who underwent therapeutic hypothermia due to hypoxic-ischemic encephalopathy between 2010 and 2020. We evaluated 125 patients who were diagnosed with moderate to severe HIE and received therapeutic hypothermia. Demographic and clinical data were obtained from electronic medical records and patient files. The patients were separated into two groups as exitus group (n = 39) and discharged group (n = 86). We aimed to evaluate factors affecting mortality. Results: We determined that the median resuscitation times were longer in the delivery room [retrospectively, 10th minutes (0–30) vs. 1 min (0–20), p < 0.05], the tenth min APGAR scores were lower [respectively, 4 (0–7) vs. 6 (3–10), p < 0.05], and the median pH value in the first blood gas taken was lower [respectively, 6.87 (6.4–7.14) vs. 6.90 (6.58–7.12), p < 0.05] in the exitus group. We also determined that multiple organ dysfunction is seen more often in the exitus group. Conclusion: This study demonstrated that the depth of acidosis in the blood gas, multiple organ dysfunction, and the existence of earlyonset seizures are the signs of poor prognosis. Therefore, physicians need to be aware of such prognostic factors to follow these patients more closely in terms of possible complications and to inform their parents.Öğe Neonatal COVID-19 case from Turkey; a Case report of neonatal(2020) Deveci, Mehmet Fatih; Gökçe, İsmail Kürsad; Özdemir, RamazanThe coronavirus disease 2019 (COVID-19) is a disease caused by a new type of coronavirus that the Severe Acute RespiratorySyndrome Coronavirus 2 (SARS-CoV-2) and has affected nearly all countries worldwide. More than 5 million global cases have beenreported to date. As first the case was identified in China in December 2019; then Turkey started reporting cases in March 2020.SARS-CoV-2 is highly infectious and especially leads to morbidity and mortality in elderly and chronically ill patients. In children,fewer and milder infections have been reported. There are 3 cases reported in the neonatal period so far in the literature. We haveobserved that the literature does not contain any newborn cases reported from our country. We report the first neonatal case ofCOVID-19 from Turkey.Öğe Neonatal COVID-19 case from Turkey; a Case report of neonatal(2020) Deveci, Mehmet Fatih; Gokce, Ismail Kursad; Ozdemir, RamazanThe coronavirus disease 2019 (COVID-19) is a disease caused by a new type of coronavirus that the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and has affected nearly all countries worldwide. More than 5 million global cases have been reported to date. As first the case was identified in China in December 2019; then Turkey started reporting cases in March 2020. SARS-CoV-2 is highly infectious and especially leads to morbidity and mortality in elderly and chronically ill patients. In children, fewer and milder infections have been reported. There are 3 cases reported in the neonatal period so far in the literature. We have observed that the literature does not contain any newborn cases reported from our country. We report the first neonatal case of COVID-19 from Turkey.Öğe Neurodevelopmental evaluation of newborns who underwent hypothermia with a diagnosis of hypoxic ischemic encephalopathy based on the Bayley-III scale(Tubitak Scientific & Technological Research Council Turkey, 2023) Deveci, Mehmet Fatih; Baysal, Senay Guven; Alagoz, Meral; Gokce, Ismail Kursad; Dogan, Derya Gumus; Ozdemir, RamazanBackground/ aim: Hypoxic ischemic encephalopathy (HIE) is one of the common causes of mortality and morbidity in newborns. Despite therapeutic hypothermia, an important treatment with proven efficacy, the morbidity and mortality rates remain high. The aim of this study was to neurodevelopmentally evaluate patients who underwent therapeutic hypothermia.Material and method: Included herein were patients who underwent hypothermia between 2018 and 2020. Their medical files were reviewed retrospectively, and their demographic and clinical information was recorded. Patients whose contact information was available were called to the developmental pediatrics outpatient clinic for a neurodevelopmental evaluation. The Bayley Scales of Infant and Toddler Development 3rd Edition (Bayley-III) was used as the evaluation tool. Laboratory values and clinical parameters of the patients were further analyzed.Results: It was found that 42 patients underwent hypothermia in 3 years, of whom 14 (33.3%) had died. Of the 28 patients who were discharged, 20 children could be reached, and a neurodevelopmental evaluation was performed. Developmental delay in the cognitive area was detected in 11 (55%) patients, delay in the language area was found in 9 (45%) patients, and delay in the motor area was found in 11 (55%) patients. The correlation and regression analysis results determined that the time to start cooling was the most effective common factor in all 3 fields of scoring. Conclusion: The time to start cooling is related to the neurodevelopmental outcomes of patients with HIE. The earlier cooling is started, the better the neurodevelopmental results. Despite therapeutic hypothermia, the neurodevelopmental development of infants may be adversely affected. These patients should be followed-up neurodevelopmentally for a long time.Öğe Yenidoğan Yoğun Bakım Ünitesinde Takip Edilen Özofagus Atrezili Olguların Değerlendirilmesi: 10 Yıllık Tek Merkez Deneyimi(2022) Deveci, Mehmet Fatih; Alagöz, Meral; Gökçe, İsmail Kürşad; Özdemir, RamazanAmaç: Özofagusun en sık görülen konjenital anomalisi olan özofagus atrezisi (ÖA), embriyonik dönemdeki fizyolojik gelişimin normal olarak tamamlanmamasından dolayı oluşmaktadır. Prematürite, düşük doğum ağırlığı ve eşlik eden anomaliler mortaliteyi artırmaktadır. Biz bu çalışmamızda; ÖA’lı olgulardaki 10 yıllık deneyimimizi ve bu hastalardaki mortalite ile ilişkili faktörleri değerlendirmeyi amaçladık. Yöntem: Ocak 2011-Aralık 2020 tarihleri arasında takip ettiğimiz ÖA’lı olgularımızı retrospektif olarak inceledik. Hastaların demografik özellikleri ve klinik izlem bilgilerini analiz ederek, mortalite ile ilişkili faktörleri değerlendirdik. Bulgular: Toplam 23 ÖA’lı olgumuzdan 9’unun (%39,1) eksitus olduğunu tespit ettik. Eksitus olan hastaların ortanca gebelik haftası ve ortanca doğum ağırlığının eksitus olmayan hastalara göre istatistiksel olarak daha düşük olduğunu bulduk [33 hafta (28-38), 37 hafta (29-40) sırasıyla (p=0,003)] [1290 gram (875- 2600), 2535 gram (1150-2900) sırasıyla (p=0,005)]. Hastaları, Spitz sınıflaması Okamoto modifikasyonuna göre gruplandırdık. Sağkalım oranları; grup 1’de %88,9, grup 2’de %50, grup 3’te %33,3 ve grup 4’te %66,7 idi. Sonuç: Düşük doğum ağırlığı ve majör kardiyak anomali ÖA’lı olgularda mortalite ile ilişkilidir. Hekimlerin mortalite ile ilişkili faktörleri iyi bilmesi ve risk sınıflaması ile sağkalım öngörüsü yapması; hasta yönetiminde faydalı olacaktır.
