Yazar "Disli, Zeliha Korkmaz" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    The effects of thiamine pyrophosphate on propofol-induced oxidative liver injury and effect on dysfunction
    (Aepress Sro, 2022) Delen, Leman Acun; Disli, Zeliha Korkmaz; Tas, Hakan G.; Kuyrukluyildiz, Ufuk; Yazici, Gulce N.; Suleyman, Bahadir; Kuzucu, Mehmet
    Propofol may cause an increase in reactive oxygen species in the body. In this study, we tested the effect of antioxidant thiamine pyrophosphate (TPP) on propofol-induced liver damage. The eighteen rats were split into three groups: HG, healthy; PP, propofol-treated (50 mg/kg) and PT, treated with propofol (50 mg/kg) and TPP (25 mg/kg). Total glutathione (tGSH), total oxidant (TOS), and total antioxidant (TAS) levels were tested together with aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and malondialdehyde (MDA). Histopathological examination of the tissues was performed. We have found that levels of MDA, TOS, ALT, AST, and LDH were all higher in PP group than in HG and PT groups (p < 0.05). In PP group, the TAS and tGSH levels were statistically substantially lower. The PT for oxidants levels showed a statistically significant reduction. In PT group, the levels of antioxidants were found to be considerably higher. The epitheliums, glands, and vascular structures of the PTs were histologically close to normal. By boosting antioxidants, TPP may help to reduce propofol-induced liver damage.
  • Küçük Resim Yok
    Öğe
    The Molecular Mechanism of the Effect of Carvacrol on Desflurane Inhalation-Induced Liver Damage in Rats
    (Colegio Farmaceuticos Provincia De Buenos Aires, 2022) Disli, Zeliha Korkmaz; Delen, Leman Acun; Tas, Hakan Gokalp; Kuyrukluyildiz, Ufuk; Disli, Olcay Murat; Yazici, Gulce Naz; Coban, Abdulkadir
    The metabolite of desflurane has been linked to hepatotoxicity. Carvacrol possesses antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, and spasmolytic properties, according to research. Our goal is to demonstrate that carvacrol protects rats' livers against repeated doses of desflurane. Healthy (HG), desflurane (DS), and carvacrol + desflurane treatment (CDS) groups were formed from 18 albino male Wistar rats. A single dosage of carvacrol and 6% desflurane was given for 2 h on the 0th and 8th days. In the CDS group, the ALT and AST, MDA, TOS, NF-xB, TNF-alpha IL1 beta levels were lower compared to the DS group (p < 0.001). The tGSH,TAS levels were found to be higher in the CDS group compared to the DS group (p < 0.001). It was determined that the mean degeneration level, Kupffer cell activation and PMNL infiltration were found to be lower compared to the DS group (p < 0.05).We confirmed that carvacol can be used in the treatment of desflurane-related liver injury.