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  • Küçük Resim
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    Comparison of clinical indications and postoperative histopathological diagnoses of hysterectomy specimens with benign preliminary diagnoses
    (2019) Bozdag, Zehra; Dizibuyuk, Omer Faruk; Bayramoglu Tepe, Neslihan
    Aim: Hysterectomy specimens constitute a large section of routine pathology practice as hysterectomy operations widely performed all over the world to manage benign gynecological disorders by the gynecologists. In this study, we aimed to evaluate hysterectomy specimens obtained due to benign preliminary diagnoses by comparing them with regard to clinical indications and postoperative histopathological diagnoses. Material and Methods: Nine hundred and forty-seven cases who underwent hysterectomy at Gaziantep University Medical Faculty Hospital between January 2012 and December 2016 were retrospectively re-evaluated with regard to clinical indications and postoperative histopathologic diagnoses. Results: Leiomyoma was the most common hysterectomy indication and accounted for 34.1% (n:323). Other indications in descending order of prevalence were as follows; abnormal uterine bleeding (n:290, 30.6%), endometrial hyperplasia (n:113, 11.9%), uterine prolapse (n:107, 11.3%), adenomyosis (n:75, 7.9%) and abnormal placentation (n:39, 4.1%). According to the final histopathological results of the hysterectomy specimens, leiomyomas (n:325, 34.3%) were the most common postoperative diagnosis followed by adenomyosis (n:150, 15.8%) and endometrial hyperplasia (n:113, 11.9%). Abnormal placentation was found in 39 cases (4.1%). Squamous intraepithelial lesions of the uterine cervix were found in 39 cases (4.1%), endometrial adenocarcinomas in 10 cases (0.9%), smooth muscle tumor with uncertain malignant potential, leiomyosarcoma and granulosa cell tumor in one patient each (0.09%). We found more than one pathology in 280 cases. The most common pathology was leiomyomas coexisting with adenomyosis (n:170, 17.9%), while others included leiomyoma coexisting with endometrial polyp (n:56, 5.9%), and leiomyoma coexisting with endometrial polyp and adenomyosis (n:54, 5.7%). Conclusion: Incidental detection of conditions such as cervical squamous intraepithelial lesions and endometrial adenocarcinomas in hysterectomy materials obtained for benign preliminary diagnoses support the importance of cervical screening test and endometrial sampling as routine processes in preoperative surgical examinations. This also stresses the importance of macroscopic examination and increased sampling in suspicious cases for pathologists
  • Küçük Resim Yok
    Öğe
    Investigation of CD47 Expression in Renal Cell Tumors and Evaluation of Its Relationship with Prognostic Parameters
    (Mdpi, 2025) Dizibuyuk, Omer Faruk; Bozdag, Zehra; Karakok, Metin
    Background/Objectives: Renal cell carcinoma is an aggressive form of kidney cancer, contributing to an estimated 138,000 deaths globally in 2017. Traditional treatments like chemotherapy and radiation are generally considered ineffective. Additionally, CD47 has been identified as a crucial tumor antigen involved in the development and progression of various cancers, including renal cell carcinoma. The interaction of CD47 with SIRP alpha triggers a don't eat me signal to the macrophages, inhibiting phagocytosis. Much progress has been made in targeting CD47 for cancer immunotherapy in solid tumors (STs) and hematological malignancies. This study aimed to evaluate CD47 expression in malignant and benign renal cell tumors and compare it with prognostic histopathological parameters. Methods: We included 160 malignant and 26 benign tumors. The malignant tumors consisted of renal cell carcinoma (RCC) subtypes including 37 clear cell, 30 chromophobe, 30 papillary type 1, 29 papillary type 2, and 34 unclassified RCC cases. As for the benign tumors, we included 26 oncocytoma cases. All samples were stained with anti-CD47 antibodies by immunohistochemistry methods. Results: The statistical analysis yielded a significant correlation between CD47 expression and survival, metastasis, and capsule invasion for the unclassified RCC cases. We did not find any further significant correlation between CD47 expression and the studied parameters. Conclusions: To the best of our knowledge, our study is the first to research CD47 expression in benign and malignant renal carcinoma subtypes. Further large-scale studies are needed to determine the expression profile of CD47 in renal cell tumors.