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  • Küçük Resim
    Öğe
    Gebelerde toksoplazma enfeksiyonunun seropozitiflik ve serokonversiyon oranları
    (Mikrobiyoloji Bülteni, 2012) Doğan, Keziban; Kafkaslı, Ayşe; Karaman, Ülkü; Atambay, Metin; Karaoğlu, Leyla; Çolak, Cemil
    Öz: oxoplasma gondii sağlıklı erişkinlerde sıklıkla asemptomatik seyrederken, gebelikte ve immünyetmezliği olan kişilerde ciddi enfeksiyonlara neden olabilir. Bu çalışmada, gebeler ile yenidoğan kordon kanında T.gondii seropozitiflik ve serokonversiyon oranlarının araştırılması ve elde edilen bulguların, yaşam tarzı ve beslenme ile ilişkisinin belirlenmesi amaçlanmıştır. Gözlemsel-kesitsel olarak planlanan çalışmaya, İnönü Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalına başvuran 312 gebe kadın (ortalama yaş: 28.1 ± 5.2 yıl) dahil edilmiş; gebe ve yenidoğanların serum örneklerinde T.gondii IgG ve IgM antikorları ticari ELISA ve indirekt immünfloresans (BioTek; ABD) yöntemleriyle araştırılmıştır. Her üç trimestırda 153, iki ve üçüncü trimestırda 58 ve üçüncü trimestırda 101 gebe çalışmaya katılmış ve doğumlarından hemen sonra kordon kanı örnekleri alınarak 312 yenidoğan taranmıştır. Çalışmada gebelerde antitoksoplazma IgG pozitiflik oranı %37.5 (117/312) olarak bulunmuş, takipli gebelerde serokonver-siyon tespit edilmemiş ve antitoksoplazma IgM tüm gebelerde negatif olarak saptanmıştır. Ayrıca, tüm yenidoğanların kord kanında da antitoksoplazma IgM negatif bulunmuş, IgG pozitifliği ise %33.3 (104/312) oranında tespit edilmiştir. Gebelere olası bulaşma yollarıyla ilgili uygulanan anket sonuçlarına göre, antitoksoplazma IgG seropozitifliği ile çiğ et tüketimi (p< 0.001) ve toprak ile uğraşma (p< 0.005) parametreleri arasında istatistiksel olarak anlamlı ilişkili bulunmuştur. Sonuç olarak, gebelerde rutin toksoplazma antikor testlerinin yapılarak seronegatif olgulara parazitten korunma yollarıyla ilgili eğitimlerin verilmesi; maliyetin düşürülmesi için ise gebelerin daha önce yapılmış testlerinin düzenli kayıt altına alınması ve periyodik olarak tekrarlanacak testlerde sadece IgM sınıfı antikorların aranması önerileri sunul- muştur.
  • Küçük Resim Yok
    Öğe
    The rates of seropositivity and seroconversion of toxoplasma infectionin pregnant women
    (Mikrobiyoloji Bulteni, 2012) Doğan, Keziban; Kafkaslı, Ayşe; Karaman, Ülkü; Atambay, Metin; Karaoğlu, Leyla; Çolak, Cemil
    Infections caused by Toxoplasma gondii are frequently asymptomatic in healthy adults, however they may be serious in pregnant women and immunocompromised patients. The aims of this study were to investigate the rates of seropositivity and seroconversion in pregnant women and newborn cord blood samples, and to evaluate those data in the view of relation to lifestyle and nutrition. A total of 312 pregnant women (mean age: 28.1 ± 5.2 years) who were admitted to and followed by gynecology clinics of Inonu University Medical School Hospital, Malatya, Turkey were included in this observational and cross-sectional study. Anti-toxoplasma IgG and IgM antibodies in pregnants and newborn cord sera were screened by commercial ELISA and immunofluorescence antibody (BioTek; USA) methods. A total of 312 sera from pregnant women and 312 cord blood samples during delivery were collected. IgG seropositivity rate in pregnants was found as 37.5% (117/312), seroconversion was not determined in restrained pregnants and T.gondii IgM was found negative in all pregnants. Also in all newborns IgM was negative and IgG seropositivity was determined as 33.3% (104/312) in cord blood. There was a statistically significant relationship between IgG seropositivity and raw meat consumption (p< 0.001) and being engaged in agriculture (p< 0.005). It was concluded that toxoplasma antibodies should routinely be searched on the first visit of the pregnants and the seronegative cases should be trained about the preventive measures related to toxoplasmosis. The follow-up of toxoplasma seronegative cases during pregnancy can be achieved by only detecting the IgM class antibodies and this will also reduce the cost of screen test.
  • Küçük Resim Yok
    Öğe
    The rates of seropositivity and seroconversion of toxoplasma ınfectionin pregnant women
    (Mıkrobıyolojı Bultenı, 2012) Doğan, Keziban; Kafkasyalı, Ayşe; Karaman, Ülkü; Atambay, Ülkü; Karaoğlu, Leyla; Çolak, Cemil
    Infections caused by Toxoplasma gondii are frequently asymptomatic in healthy adults, however they may be serious in pregnant women and immunocompromised patients. The aims of this study were to investigate the rates of seropositivity and seroconversion in pregnant women and newborn cord blood samples, and to evaluate those data in the view of relation to lifestyle and nutrition. A total of 312 pregnant women (mean age: 28.1 ± 5.2 years) who were admitted to and followed by gynecology clinics of Inonu University Medical School Hospital, Malatya, Turkey were included in this observational and cross-sectional study. Anti-toxoplasma IgG and IgM antibodies in pregnants and newborn cord sera were screened by commercial ELISA and immunofluorescence antibody (BioTek; USA) methods. A total of 312 sera from pregnant women and 312 cord blood samples during delivery were collected. IgG seropositivity rate in pregnants was found as 37.5% (117/312), seroconversion was not determined in restrained pregnants and T.gondii IgM was found negative in all pregnants. Also in all newborns IgM was negative and IgG seropositivity was determined as 33.3% (104/312) in cord blood. There was a statistically significant relationship between IgG seropositivity and raw meat consumption (p< 0.001) and being engaged in agriculture (p< 0.005). It was concluded that toxoplasma antibodies should routinely be searched on the first visit of the pregnants and the seronegative cases should be trained about the preventive measures related to toxoplasmosis. The follow-up of toxoplasma seronegative cases during pregnancy can be achieved by only detecting the IgM class antibodies and this will also reduce the cost of screen test.