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    IN VITRO ANTITUMOR ACTIVITY OF PATULIN ON LİVER AND LUNG CANCER CELL LINES
    (University of Ankara, 2022) Yüce H.; Türkmen N.B.; Şenkal S.; Özek D.A.; Bulut E.; Doğan A.; Ünüvar S.
    Objective: Patulin is a mycotoxin produced by some molds, mainly Aspergillus and Penicillium, and is responsible for mycotoxicosis in animals and humans. Although there are still no detailed data on the antitumor activity of patulin, some reports indicate that it induces cellular apoptosis and toxicity. Our aim in this study is to determine the antiproliferative and antimigration effects of patulin on human liver and lung cancer cells and its effect on gene expressions in apoptotic pathways. Material and Method: HEP3B and A549 cell lines were used to determine the efficacy of patulin in the treatment of liver and lung cancers. Cell lines were exposed to increasing concentrations of patulin (1, 2.5, 5, 10, 25, 50, and 100 µM), followed by determination of cell viability, cell migration, and apoptosis by MTS assay, wound healing assay, and RT-PCR assays. Result and Discussion: Patulin caused a dose-dependent significant decrease in cell viability and cell migration in both cancer cell lines. It also promoted the induction of apoptosis in both cell lines. Our results showed that patulin can significantly reduce tumor growth in human liver and lung cancer cells in vitro. © 2022 University of Ankara. All rights reserved.
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    Results of open reduction and salter innominate osteotomy for developmental dysplasia of the hip
    (Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Ünsal S.Ş.; Ceylan M.F.; Güner S.; Gökalp M.A.; Türktaş U.; Doğan A.; Gözen A.
    We aimed to evaluate the clinical and radiological results of open reduction (OR) and Salter innominate osteotomy (SIO) for patients with developmental dysplasia of the hip (DDH). In this study, the results of 45 instances of OR and SIO treatment on 36 DDH patients between 2004 and 2012 were evaluated retrospectively. 28 (77.77%) of the patients were female and 8 (22:33%) of them were male. The mean age was 28.8 (18-55) and the mean follow-up period was 41.8 months (6-101). A recovery percentage was calculated by measuring the acetabular index on plain radiographs recorded before surgery, immediately after surgery, and final checkup. During patients’ final checkup, the clinical evaluation was performed according to a modified version of McKay’s criteria and the evaluation of the range of the joint motion was carried out according to the Trevor-Johns-Fixen scoring system. The acetabular index values recorded from patients’ hips had an average of 39.9 (35-47) degrees before the operation, but had a mean of 30.5 (20-35) degrees after the operation and an average of 18.5 (10-30) degrees during the final checkup. Clinically, excellent results were obtained in 22 hips (49%), good results were obtained in 17 hips (38%), and satisfactory results were obtained in 4 hips. Two of the patients could not be evaluated since they could not be mobilized due to cerebral palsy. Re-dislocation emerged in 3 hips (6.6%), deep infection emerged in 1 hip (2.2%), and a supracondylar femur fracture emerged for 1 patient (2.2%). OR and Salter’s innominate osteotomy is a highly effective surgical technique in the treatment of DDH cases that have lasted more than 18 months. © 2015, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.