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    Correlation of the Brain Magnetic Resonance Imaging Findings with Biochemical Assays of the Pediatric Wilson Disease Patients: A Cohort Study
    (Turkiye Klinikleri, 2021) Doğan G.M.; Güngör Ş.; Okut G.; Cengiz A.; Doğan S.M.; Varol F.İ.; Siğirci A.
    Objective: Wilson disease is a very rare disease of copper metabolism. The objective of this study is to describe the magnetic resonance imaging (MRI) findings and to correlate the laboratory values and brain MRI findings in Wilson disease. Material and Methods: A total of 55 patients with Wilson disease and 55 normal controls underwent conventional MRI and susceptibility weighted imaging (SWI). MRI findings and laboratory findings of the patients were analyzed retrospectively. The patients were examined in 3 groups according to T1-T2 signal intensity features and in 2 groups according to the dark paramagnetic signal in SWI. Results: A total of 25 (45.4%) patients had abnormal signal intensities either on T1 or T2 sequences. The globus pallidus and the putamen were the most commonly involved localizations on T1 and T2 sequences, respectively. Eighteen patients (32.7%) had dark paramagnetic signals in the basal ganglia in SWI. Ceruloplasmin levels were low in the 90% of the patients (n=50) and 24-hour urine copper levels were found high in the 94.5% of the patients (n=52). The mean ceruloplasmin level was lower and the mean urine copper level was higher in the group with high signal intensity on T2-weighted image and in the group with darc paramagnetic signal in SWI than others. Conclusion: Although biochemical tests are used in the diagnosis of Wilson disease, additional findings are needed to confirm the diagnosis. Brain MRI findings can be helpful in the diagnosis. © 2021 by Türkiye Klinikleri.
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    Why potential donors and recipients not proceed to live kidney transplantation, Malatya algorithm
    (Asociacion Regional de Dialisi y Transplantes Renales de Capital Federal y Provincia de Buenos Aires, 2020) Simsek A.; Doğan S.M.; Gurbuz H.; Ulutas O.; Toplu S.; Turgut A.; Yildirim I.O.
    Introduction: In some countries, organ donation is not widespread enough due to medical, cultural, ethical and socioeconomic factors. Living-donor kidney transplant constitutes the main source of kidney donation. Aim: To evaluate the causes of cancellation of living-donor kidney transplant and improve the effectiveness of transplant programs. Methods: Medical records of possible donors and recipients who were evaluated for living-donor kidney transplant at a tertiary medical center between November 2010 and September 2019 were reviewed retrospectively. Results: Evaluations were performed on 364 potential donors and 338 living-donor kidney transplant recipients; 207 of the latter (61.24%) underwent living-donor kidney transplant. Immune disorders represented the majority of cancellations (38.84%). Fifty-six donors (15.38%) were rejected mainly due to renal disorders (39%). Conclusion: Timely referral of patients to transplant centers must be guaranteed in order to overcome immune problems. Transplant centers should invest in programs adequate both for their resources and for their patients: paired kidney exchange, desensitization protocols, future research, etc. © 2020, Asociacion Regional de Dialisi y Transplantes Renales de Capital Federal y Provincia de Buenos Aires. All rights reserved.