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    Antimicrobial susceptibility pattern of Escherichia coli and Klebsiella pneumoniae isolated from patients with urinary tract infections in a tertiary care hospital
    (2021) Dogan, Ahmet; Kose, Adem; Gezer, Yakup; Bayindir, Yasar; Ersoy, Yasemin; Ozden, Mehmet; Memisoglu, Funda; Altunisik Toplu, Sibel
    Aim: To determine etiological microorganisms from urine samples in patients diagnosed with UTI and to detect the antimicrobial susceptibility pattern of Escherichia coli and Klebsiella pneumoniae in a Tertiary Care Hospital. Materials and Methods: A cross-sectional study was conducted using urine culture samples and sensitivity reports collected retrospectively from our laboratory records over a period from Jan 2013 to Dec 2017. Results: A total of 729 urine culture isolates from 660 patients were included. Two-hundred eighty-four (41.8%) of the patients were male and 384 (58.2%) were female. The most common microorganisms were 46.4% E. coli, 18.2% K. pneumoniae and 12.1% Enterococcus spp., respectively. A total of 284 urine culture isolates produced extended spectrum beta-lactamases (ESBL), of which 186 (65.5%) were E. coli and 98 (34.5%) were K. pneumoniae. The most susceptible antimicrobials are meropenem, imipenem, amikacin, and fosfomycin, respectively. We determined that the antimicrobial drugs with the lowest susceptibility rates for both E. coli and K. pneumoniae were amoxicillin-clavulanate (24.5%), trimethoprim-sulfamethoxazole (30.7%) and ceftriaxone (43.2%). Additionally, their susceptibilities have gradually decreased. Ertapenem susceptibility has decreased more in K. pneumoniae isolates than E. coli. Conclusion: Antimicrobial resistance and ESBL-producing for both E. coli and K. pneumoniae have been increasing over the years. Our findings may contribute to choosing the proper antibiotic for the empirical treatment of UTI and preventing treatment failure.
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    Determination of Potential Flooding of Inebolu Basin by CN Method with a GIS-Based Software
    (Ieee, 2019) Katmerlikaya, Samet; Kurucak, Gulin; Dabanli, Ahmet; Kocamaz, Adnan Fatih; Sarica, Ogun Ozan; Dogan, Ahmet; Baltaci, Enis
    Inaccurate planning and methods of land cover / use occurring in the basins increase the intensity and frequency of flood events. The fact that floods are predictable before they occur is of great importance for preventive activities. Therefore, modeling of the basin; plays an important role in planning and developing local resources. In this study, flooding in Inebolu basin of Kastamonu province is modeled. In this context, GIS-based, flexible and user-friendly grid-based software is developed. Surface water retention capacity and the amount of water flowing on the surface were calculated for each grid. Thus, flood formation areas could be determined in the region where the study was carried out.
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    Effects of gallic acid and quercetin on the structural, thermal, spectroscopic, in vitro biocompatibility and electronic properties of Au-based hydroxyapatite structure
    (Elsevier Science Sa, 2024) Keser, Serhat; Dogan, Ahmet; Ates, Tankut; Barzinjy, Azeez A.; Ates, Burhan; Tekin, Suat; Sandal, Suleyman
    The aim of this study is investigating the structural, thermal, spectroscopic, electronic and biocompatibility properties of the Au-based hydroxyapatites containing quercetin (Q) or gallic acid (GA) at various concentration. Different characterization techniques including; XRD analysis, FTIR and Raman spectroscopies, differential thermal analysis, SEM and EDX analysis were utilized. Cell cytotoxicity test was conducted with the cells of MG63 human bone cancer, hFOB 1.19 human osteoblast and Caco-2 human colon cancer. It has been shown that the utilized samples had no cytotoxic activity on the L-929, hFOB 1.19 and MG-63 cells. However, these samples had cytotoxic activity on Caco-2. The current study showed that the bandgap of the un-doped HAp structure was 4.976 eV. The crystallite size is also affected by Au-doping, type of the as-used biological additive and its amount. Also, the as-produced samples were thermally stable in the range from room temperature to 1000 degrees C. The particle size distributions of the samples were found at variable ranges. The molar ratios were close to the stoichiometric value of 1.667. These novel findings not only expand our appreciation for the role of dopants in materials science but also opens avenues for deliberate engineering of electronic properties for enhanced performance in various applications.
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    Investigation of Viral and Atypical Pathogens in Patients with Pneumonia Who Need Intensive Care Unit
    (Bilimsel Tip Yayinevi, 2022) Dogan, Ahmet; Cinar, Yasemin Ersoy; Otlu, Baris; Kuzucu, Cigdem
    Introduction: Viral pathogens have been reported increasingly in pneumonia patients. There are few studies in Turkey on viral and atypical bacterial etiology in adult patients with community-acquired pneumonia (CAP) or hospital-acquired pneumonia (HAP). In this study, it was aimed to determine atypical and viral pathogens in patients with pneumonia requiring ICU and to research clinical progression. Materials and Methods: Adult patients admitted to adult ICUs between November 2016-October 2017 with either CAP or HAP diagnosis were included prospectively. Viral pathogens and also atypical bacterial pathogens were investigated with the in-house multiplex polymerase chain reaction method. Results: Two hundred patients were enrolled to the study, of whom 63 had CAP (31.5%) and 137 had HAP (68.5%). Viral agents were identified in 31 (15.5%) patients in total, 11 (17.5%) in CAP and 20 (14.6%) in HAP. The most identified viral etiologic agents were rhinovirus, influenza A, and coronavirus HKU. Eight patients (4%) had Mycoplasma pneumoniae. All patients were negative for Legionella pneumoniae and Chlamydophila pneumoniae. Mortality rates were 16.7% for cases with a viral etiology only, 29.2% for cases with bacterial pathogens only, and 23.5% for cases with mixed agents identified. Conclusion: Viral pathogens and M. pneumoniae should be remembered in the etiology of severe pneumonia patients.