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Öğe Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey(Türkiye'nin doğusunda non-Hodgkin lenfoma hastalarının klinik ve patolojik özellikleri, 2020) Dogan, Ali; Doğan, Narin Yıldırım; Erkurt, Mehmet Ali; Ekıncı, Ömer; Kuku, İrfan; Kaya, Hasan EminAbstract: Purpose: This study aims to evaluate the epidemiological, demographic and clinical characteristics, and prognostic factors of the patients with non-Hodgkin lymphomas (NHL). Materials and Methods: All patients diagnosed with NHL at the Department of Hematology of Inonu University Faculty of Medicine (Turkey) between 2000 and 2016 were evaluated for this study. Only patients older than 18 years were included in the study. Characteristics were evaluated by reviewing patients’ records retrospectively. Results: Of the 386 patients studied, 242 (62.7%) were male and 144 (37.3%) were female and the overall median age was 53 years (range: 18–92). The most common histological subtype of NHL was diffuse large B-cell lymphoma (DLBCL) (46.9%). In univariate analyses, advanced stage (III-IV), high-intermediate to high risk category disease based on IPI score, bone marrow involvement at diagnosis, haemoglobin levels below 10 g/dL, increased LDH levels, primary nodal involvement, the presence of B symptoms, the exigency of autologous bone marrow transplant, and not receiving rituximabbased chemotherapy regimens as the primary treatment were all associated with shorter overall survival. Conclusion: The prevalence, clinical characteristics, histopathological subtypes, treatment responses, and overall survival rates may differ because NHL is a heterogeneous disease group and may vary according to a geographical area. Therefore, treatment should be individualized according to disease subtype.Öğe Evaluation of human interferon adsorption performance of Cibacron Blue F3GA attached cryogels and interferon purification by using FPLC system(Elsevier, 2012) Dogan, Ali; Ozkara, Serpil; Sari, Mufrettin Murat; Uzun, Lokman; Denizli, AdilIn this study, we have focused our attention on preparing supermacroporous cryogels as a potential dye-affinity adsorbent for interferon purification. For this purpose, 2-hydroxyethyl methacrylate (HEMA) and Cibacron Blue F3GA (CB) were selected as main monomer and dye-ligand. Cibacron Blue F3GA attached supermacroporous poly(2-hydroxyethyl methacrylate) [poly( HEMA)/CB] cryogels were prepared and characterized by swelling test, scanning electron microscopy, elemental analysis, and FTIR. After that, the effecting factors such as pH, concentration, interaction time, and ionic strength on the interferon separation were evaluated. The maximum adsorption capacity of poly(HEMA)/CB cryogels was obtained as 38.2 mg/g at pH 6.0. Fast protein liquid chromatography (FPLC) system was used for interferon purification from human gingival fibroblast extract. The chromatography parameters, capacity and selectivity factors, resolution and theoretical plate number were found as 7.79, 9.62, 4.23 and 554, respectively. Although some decreases in total protein content, from 320 mu g to 18 mu g, and interferon activity, from 2.6 x 10(3) IU to 2.2 x 10(3) IU, were determined, specific antiviral activity increased from 7.19 IU/mu g to 122.2 IU/mu g. The purified interferon samples have 97.6% purity determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. After repeated ten adsorption-desorption cycles, no significant decrease was determined in adsorption capacity of cryogel. In result, poly(HEMA)/CB cryogels have an application potential for rapid, cheap and specific purification of interferon. (C) 2012 Elsevier B.V. All rights reserved.Öğe Flow-Mediated Vasodilatation which is diagnostic method of endothelial dysfunctions change in atrial septal defect patients before and after closure of the ASD(2020) Elcik, Deniz; Karadavut, Serhat; Dogan, Ali; Kelesoglu, Saban; Cetinkaya, Zeki; Tuncay, AydinAim: Atrial septal defect secondary pulmonary hypertension causes disruption of the endothelial structure, resulting in an increase in vasoconstrictor mediators and a decrease in vasodilator mediators. These changes on the endothelial system alter the flow in the pulmonary vein and the systemic vein bed. This also has an effect on flow mediated vasodilatation. Our purpose in this study is to evaluate the endothelial dysfunction after atrial septal defect closure via flow mediated vasodilatation. Material and Methods: Total 51 patients with pre and one mount after post treatment secundum-type atrial septal defect and 40 healthy volunteers were prospectively enrolled. Atrial septal defect was treated with transcathater closure procedure. Flow mediated vasodilatation was measured to evaluate endothelial function prior to and one month after the defect was closured.Results: Flow-mediated vasodilatation values were significantly higher in an atrial septal defect′s patient than in the healthy volunteer (11.2 ± 1.01 m/s vs. 12.7 ± 1.18 m/s, P 0.001). Flow-mediated vasodilatation values were significantly reduced at the follow-up one month after the procedure compared to baseline. Moreover, there was a significant negative correlation between pulmonary arterial pressure values and flow-mediated vasodilatation (r=-0.347; p=0.013) in the pretreatment group.Conclusion: Flow-mediated vasodilatation values were significantly lower in the right cardiac chambers, and the systolic pulmonary arterial pressure was improved. This result has shown us that atrial septal defect closure may benefit from endothelial dysfunction.Öğe Mini open surgical treatment of knee septic arthritis with local anesthesia: a prospective preliminary report(Derman Medical Publ, 2018) Ceylan, Mehmet Fethi; Guner, Savas; Turktas, Ugur; Ediz, Levent; Goktas, Ugur; Dogan, AliAim: Good pain management is provided via spinal and general anesthesia during knee joint drainage to treat septic arthritis, but the side effects are greater than those associated with local anesthesia, and the preparation process is long. Arthroscopic drainage under local anesthesia for knee septic arthritis treatment have been described, but this method requires special equipment. In this study, we aimed to evaluate the applicability of mini-open surgery under local anesthetic infiltration in cases of septic knee arthritis. Material and Method: 14 consecutive patients (eight men, six women) were admitted for knee septic arthritis treatment. Patient age ranged from 18 to 56 years, with an average age of 33 years. Drainage procedure was performed under local anesthesia, and the results were evaluated clinically. Results: The visual analog scale scores were between two and four (mean 2.8). The follow-up period was 10-21 months (mean 14.3). The Tegner and International Knee Documentation Committee scores were acceptable except for one patient. Discussion: This prospective study included mini-open surgery performed under local anesthesia on 14 septic knees, and showed that this method is safe, effective, well tolerated and be alternative to conventional techniques.Öğe The relationship between residual SYNTAX score and neutrophil/lymphocyte ratio in ST segment elevation myocardial infarction patients(2020) Dogan, AliAim: The objective of this study was to research the relation between residual SYNTAX score and neutrophil/lymphocyte ratio in patients with ST segment elevation myocardial infarction (STEMI).Material and Methods: A total of 300 patients with STEMI were included from January 2015 to February 2020. Residual SYNTAX score (RSS) was calculated for each patient after primary percutaneous coronary intervention (PCI). RSS>8 was accepted as high RSS. Clinical and laboratory features of the patients including neutrophil/lymphocyte ratio were recorded. Results: 109 (36.3%) of the patients had RSS over 8 and classified as high RSS. In the high residual SYNTAX group, while the neutrophil count was higher (p0.001), the lymphocyte count was lower (p0.001) and the N / L ratio was statistically higher (p0.001). In terms of multivariate analysis, glucose [( p :0.023, OR: 1.005, 95% CI (1.001-1.009) ], CRP [( p: 0.033, OR: 1.018, 95% CI (1.001-1035)], culprit vessel [( p 0.001, OR: 3.437, 95% CI (1.741-6.786)] and N/L ratio [( p0.001,OR: 1.559, 95% CI (1.364-1.780) were independent predictors of high RSS. The threshold value of N/L ratio for RSS was calculated to be 4.50 [76.1 % sensitivity and 82.7 % specificity, AUC: 0.823, p0.001, 95% CI: 0.771-0.876].Conclusion: Neutrophil/ lymphocyte ratio is significantly associated with high residual SYNTAX score and also an independent predictor of coronary atherosclerotic burden after PCI.Öğe SERUM NT-PROBNP, ACYLGHRELIN, DESACYLGHRELIN, OBESTATIN, AND FATTY ACID BINDING PROTEIN 4 LEVELS IN HEMODIALYSIS PATIENT(Oxford Univ Press, 2017) Taskapan, Hulya; Taskapan, Cagatay; Ozyalin, Fatma; Dogan, Ali[Abstract Not Available]
