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  • Küçük Resim
    Öğe
    Effects of Pelargonium sidoides (UMCA ®) on pulmonary contusion from blunt thoracic trauma in rats
    (2020) Dogan, Gul; Dogan, Guvenc; Karaca, Onur; Ayaz, Ercan
    Aim: The aim of the present study was to evaluate the effect of Pelargonium sidoides (UMCA ®) which was antibacterial, antiviral, anti-inflammatory and antioxidant, on pulmonary contusion (PC) caused by isolated blunt thoracic trauma (BTT) in an experimental rat model.Material and Methods: A total of 24 rats were divided into three groups: control group (CG), sham group (SG), and Pelargonium sidoidesgroup (PSG). PC was induced by isolated BTT for all the groups except the control group. Pelargonium sidoidestreatment was performed by gavage for 72 hours to the PSG after truma. Blood and tissue samples were collected from the groups. Malondialdehyde (MDA), superoxide dismutase (SOD),glutathione (GSH) and arterial blood gas parameters were measured. Lung tissue samples were collected for histopathology.Results: Histopathologically, alveolar congestion, hemorrhage,edema,disruption and neutrophil infiltrationwere significantly higher in SG when compared with CG(p0.001, p=0.007, p=0.040, p=0.003, p=0.001). Leukocyte infiltration was significantly decreased in PSG when compared with SG (p=0.025). Biochemically, MDA level was significantly higher in SG than in CG (p0.001) and GSH level was significantly lower in SG than in CG (p0.001). MDA level was significantly lower in PSG than in SG (p=0.002). In blood gas parameters PH and PO2 level was significantly higher in PSG than in SG (p=0.013, p0.001) and PCO2 level was significantly lower in PSG than in SG (p0.001).Conclusion: PS prevents further injury by decreasing leukocyte infiltration,MDAand regulating ventilation -perfusion in lung contusions. PS may have a role in the progression of inflammation but not in preventing the pathologic disruption of pulmonary parenchyma exactly.
  • Küçük Resim
    Öğe
    Foreign body aspirations in children- it is a single center experience
    (2020) Dogan, Gul; Ipek, Hulya
    Aim: Foreign body aspiration causes serious mortality in children and is an important emergency condition requiring early diagnosis and bronchoscopy in the childhood period. In our research, we evaluated data from cases treated with the diagnosis of foreign body aspiration within 9 years in our clinic in terms of the complications during and after the procedures. This study aimed to determine the demographic and clinical characteristics of patients admitted for foreign body aspiration, to evaluate bronchoscopy findings, and to compare early and late-diagnosed patients.Material and Methods: The files of cases that underwent bronchoscopy for a suspected foreign body aspiration in our hospital from January 2010 to September 2019 were investigated retrospectively. A total of 54 children were evaluated. All the bronchoscopies were performed with general anesthesia. The patients were evaluated in terms of clinical and examination findings, radiological findings, and complications that developed during and after anesthesia.Results: Of all the patients, 63% were boys. The most common findings on admission were cough in 96.3% and respiratory problems in 33.3%. Of all the patients, 40.7% had reduced respiratory sounds on the right and 44.4% had foreign objects removed from the right main bronchus. The most commonly aspirated object was walnut. During anesthesia, the most commonly observed complication was low saturation, and laryngeal edema was most common after anesthesia.Conclusion: Rapid and systematic evaluation and referral to a center with bronchoscopy experience are considered life-saving factors for children with a suspected aspiration of a foreign body.