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Öğe Does intraperitoneal medical ozone preconditioning and treatment ameliorate the methotrexate induced nephrotoxicity in rats?(E-Century Publishing Corp, 2015) Aslaner, Arif; Cakir, Tugrul; Celik, Betul; Dogan, Ugur; Mayir, Burhan; Akyuz, Cebrail; Polat, CemalMethotrexate is a chemotherapeutic agent used for many cancer treatments. It leads to toxicity with its oxidative injury. The purpose of our study is investigating the medical ozone preconditioning and treatment has any effect on the methotrexate-induced kidneys by activating antioxidant enzymes in rats. Eighteen rats were divided into three equal groups; control, Mtx without and with medical ozone. Nephrotoxicity was performed with a single dose of 20 mg/kg Mtx intraperitoneally at the fifteenth day of experiment on groups 2 and 3. Medical ozone preconditioning was performed at a dose of 25 mcg/ml (5 ml) intraperitoneally everyday in the group 3 and treated with medical ozone for five more days while group 2 was received only 5 ml of saline everyday for twenty days. All rats were sacrificed at the end of third week and the blood and kidney tissue samples were obtained to measure the levels of TNF-alpha, IL-1 beta, malondialdehyde, glutathione and myeloperoxidase. Kidney injury score was evaluated histolopatologically. Medical ozone preconditioning and treatment ameliorated the biochemical parameters and kidney injury induced by Mtx. There was significant increase in tissue MDA, MPO activity, TNF-alpha and IL-1 beta (P<0.05) and significant decrease in tissue GSH and histopathology (P<0.05) after Mtx administration. The preconditioning and treatment with medical ozone ameliorated the nephrotoxicity induced by Mtx in rats by activating antioxidant enzymes and prevented renal tissue.Öğe Effect of ozone on colon anastomoses in rat peritonitis model(Acta Cirurgica Brasileira, 2016) Cakir, Tugrul; Aslaner, Arif; Tekeli, Seckin Ozgur; Avci, Sema; Dogan, Ugur; Tekeli, Feyza; Soylu, HakanPURPOSE: To investigate the effects of medical ozone theraphy on the colon anastomosis of peritonitis model in rats. METHODS: Eighteen rats were randomly assigned into three equal groups; control, cecal punctuation and colon anastomosis and ozone theraphy. Sepsis was performed with a cecal punctuation in groups 2 and 3. The medical ozone theraphy was administered intraperitonealy for three weeks in group 3 while the other rats received saline injection. At the twenty second day serum were obtained for TNF-alpha and IL-1 beta, the colonic burst pressures were measured and colonic tissue samples were obtained for MDA and MPO levels. Histolopatological examination was evaluated with H&E stain, and Ki-67, IL-1 beta and the VEGF immunostaining densities were also compared. RESULTS: Intraperitoneal ozone administration reversed TNF-alpha, IL-1 beta, MDA and MPO levels and the colonic burst pressures. There was also a significant difference at immunostaining densities of histopathological examination. CONCLUSION: Medical ozone therapy may contribute to tissue healing by affecting the proliferation and the vascularization thus has benefits on colonic anastomosis at peritonitis in rats.Öğe Evaluation of changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels after sleeve gastrectomy(2018) Dogan, Ugur; Oruc, Mehmet TahirAim: The aim of this study was to evaluate the changes in vitamin B12, ferritin, folic acid, and thyroid hormone levels in patients with morbid obesity after laparoscopic sleeve gastrectomy (LSG). Material and Methods: A total of 85 patients who underwent LSG operation with the diagnosis of morbid obesity were included in the study. Levels of vitamin B12, ferritin, folic acid, and thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) hormone were measured using the chemiluminescence method. Pre- and postoperative levels of thyroid hormones, vitamin B12, ferritin, folic acid, and BMI values were evaluated. Results: The mean BMI decreased from 45.44 ± 3.8 kg/m2 to 39.38 ± 3.69 kg/m2 (p<0.001). The mean TSH, fT3, vitamin B12, folic acid, and ferritin levels were statistically significant lower at six months postoperatively than preoperative levels, while the mean fT4 levels were found to be significantly higher (p<0.001). Preoperative and 6thmonth postoperative ferritin levels were significantly lower in female patients than male patients (p<0.001). There was a negative correlation between age with preoperative TSH and fT3 levels. There was a positive correlation between age and preoperative and 6thmonth postoperative folic acid levels. Conclusion: Remodeling of the gastrointestinal system and endocrine alterations after LSG may result in changes in the levels of nutritional parameters such as thyroid hormone, vitamin B12, folic acid, and ferritin. Therefore, based on our study findings, we consider that the nutritional status of patients after bariatric surgery should be monitored particularly in long-term and nutritionally supported, if necessary.Öğe Experiences on the Use of Complementary and Alternative Medicine in Individuals Diagnosed With COVID-19 A Content Analysis Study(Lippincott Williams & Wilkins, 2023) Dogan, Ugur; Parlar-Kilic, SerapThe aim of this study was to examine past experiences related to the use of the complementary and alternative medicine (CAM) during the disease process by individuals diagnosed with COVID-19. Content analysis method was used for data analysis. The study consisted of 21 patients diagnosed with COVID-19, who applied to a family health center. The data were collected using an individual information form and a semistructured interview form consisting of open-ended questions. All interviews were recorded with audio recording and transcribed. Three main themes related to the use of CAM by COVID-19 patients and subthemes associated with these main themes were determined (1) while starting to use CAM; (2) experiences of CAM use; and (3) recommending CAM. During using the CAM methods, most of the participants were affected by their circle, they preferred the use of fruit/fruit juice containing vitamin C, they chose affordable and easily accessible methods, they found the methods they used useful, and recommended these methods to others. The CAM use of patients should be questioned in future studies related to COVID-19 by nurses. Nurses should inform patients with COVID-19 accurately about safety, efficacy, indications, and contraindications for CAM methods.Öğe Grape seed protects cholestatic rats liver from ischemia/reperfusion injury(Acta Cirurgica Brasileira, 2016) Cakir, Tugrul; Aslaner, Arif; Tekeli, Seckin Ozgur; Gunes, Kasim; Kinaci, Erdem; Dogan, Ugur; Tekeli, FeyzaPURPOSE: To determine the effect of grape-seed extract against ischemia/reperfusion injury in cholestatic liver. METHODS: Eighteen Wistar albino rats were divided into three groups. In control and study groups, cholestasis was provided by bile duct ligation. Seven days later, the rats were subjected to 30 min hepatic ischemia, followed by 60 min of reperfusion. Oral administration of 50 mg/kg/day grape-seed extract was started 15 days before bile duct ligation and continued to the second operation in the study group. Serum, plasma and liver samples were taken. Laboratory analysis, tissue gluthation, malondialdehyde, myeloperoxidase levels and histopathological examination were performed. RESULTS: Significant decrease in liver gluthation level and significant increase in malondialdehyde level and myeloperoxidase activity were observed after ischemia/reperfusion in cholestatic rats. Serum and plasma levels for laboratory analysis were also significantly higher in cholestatic I/R group. Hepatic necrosis and fibrosis were detected in histopathological examination. Oral grape-seed extract administiration reversed all these parameters and histopathological findings except serum bilirubin levels. CONCLUSION: Oral grape-seed extract treatment can improve liver functions and attenuate the inflammation and oxidative stress in cholestatic ischemia/reperfusion injury.Öğe Medical ozone treatment ameliorates the acute distal colitis in rats(Acta Cirurgica Brasileira, 2016) Aslaner, Arif; Cakir, Tugrul; Tekeli, Seckin Ozgur; Avci, Sema; Dogan, Ugur; Tekeli, Feyza; Soylu, HakanPURPOSE: To investigate the effect of medical ozone treatment on the experimental acute distal colitis in rats. METHODS: Eighteen rats were randomly distributed into three equal groups; control, acute distal colitis (ADC) without and with medical ozone treatment. Rats in the control group were taken saline. ADC was performed by rectal way with 4% acetic acid in groups 2 and 3, and the group 3 was treated with medical ozone for three weeks both rectally and intraperitoneally. At the twenty second day the distal colons samples were obtained for malondialdehyde and myeloperoxidase, blood samples were obtained to measure the levels of TNF-alpha and IL-1 beta levels. Histolopatological examination was evaluated with Ki-67, IL-1 beta and VEGF immunostaining densities. RESULTS: There was significant increase in tissue MDA, MPO activity, TNF-alpha and IL-1 beta after ozone administration. There was also a significant difference at immunostaining densities of histopathological examination. CONCLUSIONS: Medical ozone treatment ameliorated the experimental acute distal colitis induced by acetic acid in rats. Its possible effect is by means of decreasing inflammation, edema, and affecting the proliferation and the vascularization.Öğe Treatment of gastric gastrointestinal stromal tumor by laparoscopic sleeve gastrectomy in a morbidly obese patient(2018) Dogan, Ugur; Oruc, Mehmet Tahir; Oner, Osman Zekai; Yardimci, Erdem Can; Sakar, Alkan; Tosun Yildirim, Hulya
